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See detailOlder adults show a higher heartbeat-evoked potential than young adults and a negative association with everyday metacognition
Kamp, Siri-Maria; Schulz, André UL; Forester, Glen et al

in Brain Research (2021), 1752(1), 147238

The ability to monitor internal bodily and cognitive processes is essential for everyday functioning and independence in older adults, because it allows for adjustments when lapses in performance are ... [more ▼]

The ability to monitor internal bodily and cognitive processes is essential for everyday functioning and independence in older adults, because it allows for adjustments when lapses in performance are imminent. In the present study, age-related morphological changes to the heartbeat evoked potential (HEP), an electrophysiological cortical representation of cardiac signals, and its association with self-reported everyday cognition were examined. A community sample of older adults showed an increased HEP amplitude, which could reflect a stronger representation of early stages of cardiac interoception, and a more anterior scalp distribution of the HEP, suggesting a more widespread configuration of the underlying neural generators, compared to a group of young adults. Furthermore, in older adults, HEP amplitude was negatively correlated with self-estimated everyday cognitive functioning. Older adults with pronounced cortical representations of peripheral signals may thus be more likely to take note of lapses in their own bodily and cognitive function, leading to lower estimates of their cognitive abilities. These results provide novel insights into age-related changes in interoceptive processing and their association with metacognitive judgments, with potentially far-reaching implications for cognitive aging and age-related cognitive decline. [less ▲]

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See detailNeurofilament L gene is not a genetic factor of sporadic and familial Parkinson's disease.
Rahner, Nils; Holzmann, Carsten; Krüger, Rejko UL et al

in Brain research (2002), 951(1), 82-6

Mutations in two genes, alpha-synuclein and parkin, have been identified as some rare causes for familial Parkinson's disease (PD). alpha-Synuclein and parkin protein have subsequently been identified in ... [more ▼]

Mutations in two genes, alpha-synuclein and parkin, have been identified as some rare causes for familial Parkinson's disease (PD). alpha-Synuclein and parkin protein have subsequently been identified in Lewy bodies (LB). To gain further insight into the pathogenesis of PD we investigated the role of neurofilament light (NF-L), another component of LB aggregation. A detailed mutation search of the NF-L gene in 328 sporadic and familial PD patients of German ancestry revealed three silent DNA changes (G163A, C224T, C487T) in three unrelated patients. Analysis of the promoter region of the NF-L gene identified a total of three base pair substitutions defining five haplotypes. Association studies based on these haplotypes revealed no significant differences between PD patients and 344 control individuals. Therefore, NF-L is unlikely to play a major role in the pathogenesis of PD. [less ▲]

Detailed reference viewed: 113 (0 UL)
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See detailMorphine, 5-HT 2 and 5-HT 3 recpror antagonists reduce c-Fos expresion in the trigeminal nuclear complex follwing noxious chemical stimulation of the rat nasal mucosa
Ebersberger, Andrea; Anton, Fernand UL; Tölle, Thomas et al

in Brain Research (1995), 676(2), 336-342

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See detailNADPH-diaphorase reactivity in articular afferents of a normal and inflamed knee joint in the cat.
Bscheidl, Christoph; Hanesch, Ulrike UL; Heppelmann, Bernd

in Brain Research (1994), 668

Detailed reference viewed: 80 (0 UL)
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See detailNeurokinin A-like immunoreactivity in articular afferents of the cat
Hanesch, Ulrike UL; Heppelmann, Bernd; Schmidt, Robert

in Brain Research (1992), 586

Detailed reference viewed: 93 (0 UL)
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See detailSelective excitation by capsaicin of mechano-heat sensitive nociceptors in rat skin
Szolcsanyi, Janos; Anton, Fernand UL; Reeh, Peter-Werner et al

in Brain Research (1988), 446(2), 262-268

Detailed reference viewed: 78 (0 UL)
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See detailSI nociceptive neurons participate in the encoding proces by which monkeys perceive the intnesity of noxious thermal stimulation
Kenshalo, Dan R; Chudler, Eric H; Anton, Fernand UL et al

in Brain Research (1988), 454(1-2), 378-382

Detailed reference viewed: 23 (0 UL)