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See detailThe essential role of lipids in Alzheimer’s disease
Garcia, Pierre UL

in Biochimie (2009), 6

In the absence of efficient diagnostic and therapeutic tools, Alzheimer’s disease (AD) is a major public health concern due to longer life expectancy in the Western countries. Although the precise cause of ... [more ▼]

In the absence of efficient diagnostic and therapeutic tools, Alzheimer’s disease (AD) is a major public health concern due to longer life expectancy in the Western countries. Although the precise cause of AD is still unknown, soluble b-amyloid (Ab) oligomers are considered the proximate effectors of the synaptic injury and neuronal death occurring in the early stages of AD. Ab oligomers may directly interact with the synaptic membrane, leading to impairment of synaptic functions and subsequent signalling pathways triggering neurodegeneration. Therefore, membrane structure and lipid status should be considered determinant factors in Ab-oligomer-induced synaptic and cell injuries, and therefore AD progression. Numerous epidemiological studies have highlighted close relationships between AD inci- dence and dietary patterns. Among the nutritional factors involved, lipids significantly influence AD pathogenesis. It is likely that maintenance of adequate membrane lipid content could prevent the production of Ab peptide as well as its deleterious effects upon its interaction with synaptic membrane, thereby protecting neurons from Ab-induced neurodegeneration. As major constituents of neuronal lipids, n-3 polyunsaturated fatty acids are of particular interest in the prevention of AD valuable diet ingredients whose neuroprotective properties could be essential for designing preventive nutrition- based strategies. In this review, we discuss the functional relevance of neuronal membrane features with respect to susceptibility to Ab oligomers and AD pathogenesis, as well as the prospective capacities of lipids to prevent or to delay the disease. [less ▲]

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