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See detailNutrition and the 2020 Pandemic
Stover, Patrick; Balling, Rudolf UL

in Annual Review Of Nutrition (2020)

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See detailAddressing the Increased Expectations of Nutrition
Balling, Rudolf UL; Stover, Patrick

in Annual Review of Nutrition (2019)

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See detailSources and Functions of Extracellular Small RNAs in Human Circulation.
Fritz, Joëlle UL; Heintz, Anna UL; Ghosal, Anubrata et al

in Annual review of nutrition (2016)

Various biotypes of endogenous small RNAs (sRNAs) have been detected in human circulation, including microRNAs, transfer RNAs, ribosomal RNA, and yRNA fragments. These extracellular sRNAs (ex-sRNAs) are ... [more ▼]

Various biotypes of endogenous small RNAs (sRNAs) have been detected in human circulation, including microRNAs, transfer RNAs, ribosomal RNA, and yRNA fragments. These extracellular sRNAs (ex-sRNAs) are packaged and secreted by many different cell types. Ex-sRNAs exhibit differences in abundance in several disease states and have, therefore, been proposed for use as effective biomarkers. Furthermore, exosome-borne ex-sRNAs have been reported to elicit physiological responses in acceptor cells. Exogenous ex-sRNAs derived from diet (most prominently from plants) and microorganisms have also been reported in human blood. Essential issues that remain to be conclusively addressed concern the (a) presence and sources of exogenous ex-sRNAs in human bodily fluids, (b) detection and measurement of ex-sRNAs in human circulation, (c) selectivity of ex-sRNA export and import, (d) sensitivity and specificity of ex-sRNA delivery to cellular targets, and (e) cell-, tissue-, organ-, and organism-wide impacts of ex-sRNA-mediated cell-to-cell communication. We survey the present state of knowledge of most of these issues in this review. Expected final online publication date for the Annual Review of Nutrition Volume 36 is July 17, 2016. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates. [less ▲]

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See detailItaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite
Cordes, Thekla; Michelucci, Alessandro UL; Hiller, Karsten UL

in Annual review of nutrition (2015)

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