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   Gene expression profiling related to anti-inflammatory properties of curcumin in K562 leukemia cells; Eifes, Serge  ; et alin Annals of the New York Academy of Sciences (2009), 1171 A strong relationship exists between inflammation and carcinogenesis. To bring insights into the anti-inflammatory mechanisms by which chemopreventive agents, such as curcumin, are able to counteract the ... [more ▼] A strong relationship exists between inflammation and carcinogenesis. To bring insights into the anti-inflammatory mechanisms by which chemopreventive agents, such as curcumin, are able to counteract the action of inflammation mediators, such as tumor necrosis factor-alpha (TNF-alpha), we compared gene expression profiles in K562 cells treated with curcumin-TNF-alpha versus TNF-alpha alone. Microarray data analysis revealed that, among the 376 differentially expressed genes by curcumin treatment, genes belonging to the cell cycle and the Janus kinase-signal transducer and activator of transcription signaling pathways were downregulated. This study also indicated that the upregulation of the heat shock family genes is highly implicated in the anti-inflammatory effect of curcumin. [less ▲] Detailed reference viewed: 105 (0 UL)Plasma membrane calcium ATPase and its relationship to nitric oxide signaling in the heart.; ; Neyses, Ludwig in Annals of the New York Academy of Sciences (2007), 1099 The plasma membrane calcium/calmodulin-dependent ATPase (PMCA) is a ubiquitously expressed calcium-extruding enzymatic pump. In the majority of cells the main function of PMCA is as the only system to ... [more ▼] The plasma membrane calcium/calmodulin-dependent ATPase (PMCA) is a ubiquitously expressed calcium-extruding enzymatic pump. In the majority of cells the main function of PMCA is as the only system to extrude calcium from the cytosol, however, in the excitable cells of the heart it has only a minor role in the bulk removal of calcium compared to the sodium-calcium exchanger. There is increasing evidence to suggest that PMCA has an additional role as a potential modulator of a number of signal transduction pathways. Of key interest in the heart is the functional interaction between the calcium/calmodulin-dependent enzyme neuronal nitric oxide synthase (nNOS) and isoform 4 of PMCA. Nitric oxide production from nNOS is known to be important in the regulation of excitation-contraction (EC) coupling and subsequently contractility. This article will focus on recent evidence suggesting that PMCA4 has a regulatory role in the nitric oxide signaling pathway in the heart. [less ▲] Detailed reference viewed: 107 (0 UL)A psychobiological perspective on genetic determinants of hypothalamus-pituitary-adrenal axis activity; ; et al in Annals of the New York Academy of Sciences (2004), 1032 Detailed reference viewed: 33 (0 UL)From developmental biology to developmental toxicology.Balling, Rudi ; in Annals of the New York Academy of Sciences (2000), 919 Progress derived from the human genome project will have tremendous impact on toxicology. Questions concerning genetic susceptibility or resistance to toxic compound exposure and the dissection of the ... [more ▼] Progress derived from the human genome project will have tremendous impact on toxicology. Questions concerning genetic susceptibility or resistance to toxic compound exposure and the dissection of the molecular mechanisms involved will be at the forefront of future toxicological research. In recent years, it was recognized that many of the molecular control mechanisms of embryogenesis have been conserved during evolution. The relevance of these observations for toxicology and the application of genetic approaches using mouse mutants as a tool for functional genome analysis are discussed. [less ▲] Detailed reference viewed: 125 (3 UL)Pax genes and skeletal development.Balling, Rudi ; ; et alin Annals of the New York Academy of Sciences (1996), 785 Detailed reference viewed: 100 (0 UL) |
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