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See detailA systems biology approach towards understanding nuclear receptor interactions: Implications at the endocrine-xenobiotic signalling interface
Kolodkin, Alexey UL; Phillips, Anna; Hood, Steve et al

in Toxicology (2011), 290(2-3), 131-131

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See detailDesign principles of nuclear receptor signalling: How complex networking improves signal transduction
Kolodkin, Alexey UL; Bruggeman, Frank J.; Plant, Nick et al

in Toxicology (2011), 290(2-3), 131-132

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See detailDirect effects of nicotine on rabbit preimplantation embryos.
Balling, Rudi UL; Beier, H. M.

in Toxicology (1985), 34(4), 309-13

The effects of various concentrations of nicotine on the in vitro development of 1-cell rabbit preimplantation embryos and on the DNA-synthesis of 4-day-old rabbit blastocysts are investigated. Exposure ... [more ▼]

The effects of various concentrations of nicotine on the in vitro development of 1-cell rabbit preimplantation embryos and on the DNA-synthesis of 4-day-old rabbit blastocysts are investigated. Exposure of rabbit preimplantation embryos to concentrations of nicotine higher than 1 X 10(-3) M results in a marked decrease in the in vitro development and in DNA-synthesis. Concentrations of nicotine below 1 X 10(-3) M have no effect on these early embryos. It can be concluded that the concentrations of nicotine which exert a direct embryotoxic effect are higher than the concentrations that may be expected in the blood circulation of humans considered to be "normal smokers". [less ▲]

Detailed reference viewed: 145 (1 UL)