Comparison of ODE-based models for reactive oxygen species regulation system

in Proceedings of ICCSA 2014 (2014, June)

Reactive oxygen species (ROS) play important role in the functioning of any cell and especially in the lifecycle of mitochondria. Since the action of ROS can be both positive and negative then the ... [more ▼]

Reactive oxygen species (ROS) play important role in the functioning of any cell and especially in the lifecycle of mitochondria. Since the action of ROS can be both positive and negative then the remarkable role can be played by ROS regulation system. We constructed three different ODE based kinetic models of different complexity for the ROS management system and shown the difference in the dynamics of these systems under different conditions. Using results of numerical simulation we showed that extraction of some subsystems can make the model more unstable. We also introduced the objective function for comparison of the models with structure of different complexity [less ▲]