References of "Genome informatics. International Conference on Genome Informatics"
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See detailThe role of IP3R clustering in Ca2+ signaling.
Skupin, Alexander UL; Falcke, Martin

in Genome informatics. International Conference on Genome Informatics (2008), 20

Ca(2+) is the most important second messenger controlling a variety of intracellular processes by oscillations of the cytosolic Ca(2+) concentration. These oscillations occur by Ca(2+) release from the ... [more ▼]

Ca(2+) is the most important second messenger controlling a variety of intracellular processes by oscillations of the cytosolic Ca(2+) concentration. These oscillations occur by Ca(2+) release from the endoplasmic reticulum (ER) into the cytosol through channels and the re-uptake of Ca(2+) into the ER by pumps. A common channel type present in many cell types is the inositol trisphosphate receptor (IP(3)R), which is activated by IP(3) and Ca(2+) itself leading to Ca(2+) induced Ca(2+) release (CICR). We have shown in an experimental study, that Ca(2+) oscillations are sequences of random spikes that occur by wave nucleation. We use here our recently developed model for Ca(2+) dynamics in 3 dimension to illuminate the role of IP(3)R clustering within spatial extended systems. [less ▲]

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See detailStatistical properties and information content of calcium oscillations.
Skupin, Alexander UL; Falcke, Martin

in Genome informatics. International Conference on Genome Informatics (2007), 18

Calcium is the most important second messenger in living cells serving as a critical link between a large variety of extracellular stimuli and the intracellular target. Often, the Ca(2+) signal is carried ... [more ▼]

Calcium is the most important second messenger in living cells serving as a critical link between a large variety of extracellular stimuli and the intracellular target. Often, the Ca(2+) signal is carried by [Ca(2+)] oscillations. Our recent studies have demonstrated that in contrast to traditional ideas Ca(2+) oscillations do not occur by simple synchronization of channel clusters opening and closing in an oscillatory fashion but originate from microscopic fluctuation caused by the stochastic binding of the ligands Ca(2+) and IP(3) to the receptor's binding sites. They are orchestrated spatially on the cell level by wave nucleation. In this paper we analyze the stochastic data and show how internal properties can be determined from global observations. Further, we analyze the information content of spontaneous and stimulated oscillations. [less ▲]

Detailed reference viewed: 134 (2 UL)