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See detailA covalent calmodulin inhibitor as a tool to study cellular mechanisms of K-Ras-driven stemness
Okutachi, Sunday Ojochegbe UL; Manoharan, Ganesh Babu UL; Kiriazis, Alexandros et al

in Frontiers in Cell and Developmental Biology (2021)

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See detailCharacterization of DNA Methylomic signatures in induced pluripotent stem cells during neuronal differentiation
Imm, Jennifer; Pishva, Ehsan; Ali, Muhammad et al

in Frontiers in Cell and Developmental Biology (2021)

In development, differentiation from a pluripotent state results in global epigenetic changes, although the extent to which this occurs in induced pluripotent stem cell based neuronal models has not been ... [more ▼]

In development, differentiation from a pluripotent state results in global epigenetic changes, although the extent to which this occurs in induced pluripotent stem cell based neuronal models has not been extensively characterized. In the present study, induced pluripotent stem cell colonies (33Qn1 line) were differentiated and collected at four time-points, with DNA methylation assessed using the Illumina Infinium Human Methylation EPIC BeadChip array. Dynamic changes in DNA methylation occurring during differentiation were investigated using a data-driven trajectory inference method. We identified a large number of Bonferroni-significant loci that showed progressive alterations in DNA methylation during neuronal differentiation. A gene-gene interaction network analysis identified 60 densely connected genes that were influential in the differentiation of neurons, with STAT3 being the gene with the highest connectivity. [less ▲]

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See detailMidbrain organoids: A new tool to investigate Parkinson's disease
Smits, Lisa UL; Schwamborn, Jens Christian UL

in Frontiers in Cell and Developmental Biology (2020)

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