References of "Brain stimulation"
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See detailHabenula deep brain stimulation for refractory bipolar disorder.
Zhang, Chencheng; Kim, Seung-Goo; Li, Dianyou et al

in Brain stimulation (2019)

Bipolar disorder (BD) is a mood disorder associated with significant morbidity and mortality. In many cases, BD can be managed with pharmacotherapy, psychological therapy, or electroconvulsive therapy [1 ... [more ▼]

Bipolar disorder (BD) is a mood disorder associated with significant morbidity and mortality. In many cases, BD can be managed with pharmacotherapy, psychological therapy, or electroconvulsive therapy [1]. For some afflicted patients, however, BD is a chronic and severely disabling condition that is resistant to the aforementioned treatments. Deep brain stimulation (DBS) offers a safe and effective neurosurgical treatment for otherwise refractory movement disorders and obsessive-compulsive disorder [2,3]. [less ▲]

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See detailPost-operative deep brain stimulation assessment: Automatic data integration and report generation
Husch, Andreas UL; Petersen, Mikkel V.; Gemmar, Peter et al

in Brain Stimulation (2018)

Background The gold standard for post-operative deep brain stimulation (DBS) parameter tuning is a monopolar review of all stimulation contacts, a strategy being challenged by recent developments of more ... [more ▼]

Background The gold standard for post-operative deep brain stimulation (DBS) parameter tuning is a monopolar review of all stimulation contacts, a strategy being challenged by recent developments of more complex electrode leads. Objective Providing a method to guide clinicians on DBS assessment and parameter tuning by automatically integrating patient individual data. Methods We present a fully automatic method for visualization of individual deep brain structures in relation to a DBS lead by combining precise electrode recovery from post-operative imaging with individual estimates of deep brain morphology utilizing a 7T-MRI deep brain atlas. Results The method was evaluated on 20 STN DBS cases. It demonstrated robust automatic creation of 3D-enabled PDF reports visualizing electrode to brain structure relations and proved valuable in detecting miss placed electrodes. Discussion Automatic DBS assessment is feasible and can conveniently provide clinicians with relevant information on DBS contact positions in relation to important anatomical structures. [less ▲]

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See detailThe COMT Val/Met polymorphism modulates effects of tDCS on response inhibition
Nieratschker, V.; Kiefer, C.; Giel, K. et al

in Brain stimulation (2015), 8(2), 283-288

BACKGROUND: Transcranial direct current stimulation (tDCS) is increasingly discussed as a new option to support the cognitive rehabilitation in neuropsychiatric disorders. However, the therapeutic impact ... [more ▼]

BACKGROUND: Transcranial direct current stimulation (tDCS) is increasingly discussed as a new option to support the cognitive rehabilitation in neuropsychiatric disorders. However, the therapeutic impact of tDCS is limited by high inter-individual variability. Genetic factors most likely contribute to this variability by modulating the effects of tDCS. OBJECTIVES: We aimed to investigate the influence of the COMT Val(108/158)Met polymorphism on cathodal tDCS effects on executive functioning. METHODS: Cathodal tDCS was applied to the left dorsolateral prefrontal cortex (dlPFC) during the performance of a parametric Go/No-Go test. RESULTS: We demonstrate an impairing effect of cathodal tDCS to the dlPFC on response inhibition. This effect was only found in individuals homozygous for the Val-allele of the COMT Val(108/158)Met polymorphism. No effects of stimulation on executive functions in Met-allele carriers were detected. CONCLUSION: Our data indicate that i) cathodal, excitability reducing tDCS, interferes with inhibitory cognitive control, ii) the left dlPFC is critically involved in the neuronal network underlying the control of response inhibition, and iii) the COMT Val(108/158)Met polymorphism modulates the impact of cathodal tDCS on inhibitory control. Together with our previous finding that anodal tDCS selectively impairs set-shifting abilities in COMT Met/Met homozygous individuals, these results indicate that genetic factors modulate effects of tDCS on cognitive performance. Therefore, future tDCS research should account for genetic variability in the design and analysis of neurocognitive as well as therapeutic applications to reduce the variability of results and facilitate individualized neurostimulation approaches. [less ▲]

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