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See detailSub-millisecond time-resolved small-angle neutron scattering measurements at NIST
Glinka, Charles; Bleuel, Markus; Tsai, Peter et al

in Journal of Applied Crystallography (2020), 53(3),

Instrumentation for time-resolved small-angle neutron scattering measurements with sub-millisecond time resolution, based on Gähler's TISANE (time-involved small-angle neutron experiments) concept, is in ... [more ▼]

Instrumentation for time-resolved small-angle neutron scattering measurements with sub-millisecond time resolution, based on Gähler's TISANE (time-involved small-angle neutron experiments) concept, is in operation at NIST's Center for Neutron Research. This implementation of the technique includes novel electronics for synchronizing the neutron pulses from high-speed counter-rotating choppers with a periodic stimulus applied to a sample. Instrumentation details are described along with measurements demonstrating the utility of the technique for elucidating the reorientation dynamics of anisometric magnetic particles. [less ▲]

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See detailVom Aktienbankrecht zum Aktienintermediärsrecht
Zetzsche, Dirk Andreas UL; Noack

in Festschrift K. Hopt II (2020)

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See detailMentalization and Criterion A of the AMPD: Results from a clinical and nonclinical sample
Zettl, M.; Volkert, J.; Vögele, Claus UL et al

in Personality Disorders: Theory, Research, and Treatment (2020), 11(3), 191-202

Objective: Criterion A of the alternative model for the classification of personality disorders in the DSM-5 introduced the Level of Personality Functioning Scale (LPFS), a dimensional model for the ... [more ▼]

Objective: Criterion A of the alternative model for the classification of personality disorders in the DSM-5 introduced the Level of Personality Functioning Scale (LPFS), a dimensional model for the assessment of impairments in self and interpersonal functioning. The LPFS was developed based on a review of different measures of personality functioning, such as the Reflective Functioning Scale, a measure of mentalizing. This study investigated the empirical overlap between LPFS and mentalization. Methods: The study sample included adult inpatients (n = 55) with a mental disorder and a healthy adult control group (n = 55). All participants were examined regarding the LPFS using the Semi-Structured Interview for Personality Functioning DSM-5 (STiP-5.1); mentalizing was assessed with the Brief Reflective Functioning Interview and coded with the Reflective Functioning Scale. We used structural equation modeling to investigate the relationship between LPFS domains and mentalization. Correlation analysis was used to examine the agreement between interview-rated LPFS and self-report measures of personality dysfunction. Results: All domains of the LPFS were significantly related to mentalizing. Interview-rated LPFS was significantly associated with self-reported personality dysfunction. Conclusion: The findings support the notion that the LPFS and mentalization share a strong conceptual and operational overlap by demonstrating that both constructs are empirically interrelated. The results yield further support for the validity of the LPFS as a dimensional model for the assessment of personality disorder severity. [less ▲]

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See detailLogic Beyond Formulas: A Graphical Proof System
Horne, Ross James UL; Acclavio, Matteo UL; Straßburger, Lutz

in LICS '20: Proceedings of the 35th Annual ACM/IEEE Symposium on Logic in Computer Science (2020)

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See detailGravity monitoring of underground flash flood events to study their impact on groundwater recharge and the distribution of karst voids
Watlet, A.; Van Camp, M.; Francis, Olivier UL et al

in Water Resources Research (2020), 56(n/a), 2019026673

Abstract Flash flood events are expected to become increasingly common with the global increases in weather extremes. They are a significant natural hazard that affects karst landscapes, which host large ... [more ▼]

Abstract Flash flood events are expected to become increasingly common with the global increases in weather extremes. They are a significant natural hazard that affects karst landscapes, which host large resources of drinking water worldwide. The role played by underground flood events in the karst aquifer recharge is complex due to the heterogeneity of the basement which remains poorly understood. We present the analysis of 20 in-cave flash flood events affecting the Rochefort karst system (Belgium) using continuous gravity measurements at one single station, and water level sensors installed in caves. Underground flood events typically produce a peak in the gravity signal, due to an increase in the associated mass change. After the flood, the gravity values drop but remain slightly increased compared to before the flood event. Via forward gravity modeling, we demonstrate that this remaining anomaly can be reasonably explained by the infiltration of local rainfall within the karst system rather than by allogenic recharge of the aquifer. Flash floods are mainly restricted to connected voids. This allows us to utilize them as proxies to investigate the distribution of cavities in the karst system. Forward modeling of the gravitational attraction induced by the mapped caves being flooded yields a gravity signal much smaller than the observed one. We conclude that at least 50 more cavities than those previously mapped are required to match the measured anomalies. This presents opportunities for implementing similar approaches in other diverse porous media, using gravity monitoring of hydrological processes (e.g. infiltration fronts, hydrothermalism or tide effects in coastal aquifers) as proxies to characterize underground properties. [less ▲]

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See detailGenetic and environmental variation in political orientation in adolescence and early adulthood: A Nuclear Twin Family Analysis.
Hufer, Anke; Kornadt, Anna Elena UL; Kandler, Christian et al

in Journal of Personality and Social Psychology (2020), 118(4), 762-766

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See detailExpanded coverage of non-targeted LC-HRMS using atmospheric pressure chemical ionization: a case study with ENTACT mixtures.
Singh, Randolph UL; Chao, Alex; Phillips, Katherine A. et al

in Analytical and Bioanalytical Chemistry (2020)

Non-targeted analysis (NTA) is a rapidly evolving analytical technique with numerous opportunities to improve and expand instrumental and data analysis methods. In this work, NTA was performed on eight ... [more ▼]

Non-targeted analysis (NTA) is a rapidly evolving analytical technique with numerous opportunities to improve and expand instrumental and data analysis methods. In this work, NTA was performed on eight synthetic mixtures containing 1264 unique chemical substances from the U.S. Environmental Protection Agency’s Non-Targeted Analysis Collaborative Trial (ENTACT). These mixtures were analyzed by atmospheric pressure chemical ionization (APCI) and electrospray ionization (ESI) using both positive and negative polarities for a total of four modes. Out of the 1264 ENTACT chemical substances, 1116 were detected in at least one ionization mode, 185 chemicals were detected using all four ionization modes, whereas 148 were not detected. Forty-four chemicals were detected only by APCI, and 181 were detected only by ESI. Molecular descriptors and physicochemical properties were used to assess which ionization type was preferred for a given compound. One ToxPrint substructure (naphthalene group) was found to be enriched in compounds only detected using APCI, and eight ToxPrints (e.g., several alcohol moieties) were enriched in compounds only detected using ESI. Examination of physicochemical parameters for ENTACT chemicals suggests that those with higher aqueous solubility preferentially ionized by ESI−. While ESI typically detects a larger number of compounds, APCI offers chromatograms with less background, fewer co-elutions, and additional chemical space coverage, suggesting both should be considered for broader coverage in future NTA research. [less ▲]

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See detailComputational Metabolomics: From Cheminformatics to Machine Learning (Dagstuhl Seminar 20051)
Böcker, Sebastian; Broeckling, Corey; Schymanski, Emma UL et al

in Dagstuhl Reports (2020)

Dagstuhl Seminar 20051 on Computational Metabolomics is the third edition of seminars onthis topic and focused on Cheminformatics and Machine Learning. With the advent of higherprecision instrumentation ... [more ▼]

Dagstuhl Seminar 20051 on Computational Metabolomics is the third edition of seminars onthis topic and focused on Cheminformatics and Machine Learning. With the advent of higherprecision instrumentation, application of metabolomics to a wider variety of small molecules, andever increasing amounts of raw and processed data available, developments in cheminformaticsand machine learning are sorely needed to facilitate interoperability and leverage further insightsfrom these data. Following on from Seminars 17491 and 15492, this edition convened bothexperimental and computational experts, many of whom had attended the previous sessions andbrought much-valued perspective to the week’s proceedings and discussions. Throughout theweek, participants first debated on what topics to discuss in detail, before dispersing into smaller,focused working groups for more in-depth discussions. This dynamic format was found to bemost productive and ensured active engagement amongst the participants. The abstracts inthis report reflect these working group discussions, in addition to summarising several informalevening sessions. Action points to follow-up on after the seminar were also discussed, includingfuture workshops and possibly another Dagstuhl seminar in late 2021 or 2022. [less ▲]

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See detailA European proposal for quality control and quality assurance of tandem mass spectral libraries
Oberacher, Herbert; Sasse, Michael; Antignac, Jean-Philippe et al

in Environmental Sciences Europe (2020), 32(1), 1--19

Background: High resolution mass spectrometry (HRMS) is being used increasingly in the context of suspect and non-targeted screening for the identification of bioorganic molecules. There is ... [more ▼]

Background: High resolution mass spectrometry (HRMS) is being used increasingly in the context of suspect and non-targeted screening for the identification of bioorganic molecules. There is correspondingly increasing awareness that higher confidence identification will require a systematic, group effort to increase the fraction of compounds with tandem mass spectra available in central, publicly available resources. While typical suspect screening efforts will only result in tentative annotations with a moderate level of confidence, library spectral matches will yield higher confidence or even full confirmation of the identity if the reference standards are available. Results: This article first explores representative percent coverage of measured tandem mass spectra in selected major environmental suspect databases of interest in the context of human biomonitoring, demonstrating the current extensive gap between the number of potential substances of interest (up to hundreds of thousands) and measured spectra (0.57–3.6% of the total chemicals have spectral information available). Furthermore, certain datasets are benchmarked, based on previous efforts, to show the extent to which acquired experimental data were comparable between laboratories, even with HRMS instruments based on different technologies (i.e., quadrupole–quadrupole-time of flight versus ion trap/quadrupole-Orbitrap). Instruments and settings that are less comparable are also revealed, primarily linear ion trap instruments, which show distinctly lower comparability. Conclusions: Based on these efforts, harmonization guidelines for the acquisition and processing of tandem mass spectrometry data are proposed to enable European (and ideally worldwide) laboratories to contribute to common resources, without requiring extensive changes to their current in house methods. [less ▲]

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See detailSecuritizations
Zetzsche, Dirk Andreas UL; Hooghiemstra, S.

in The AIFM Directive (2020)

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See detailFintech Toolkit: Smart Regulatory and Market Approaches to Financial Technology Innovation
Zetzsche, Dirk Andreas UL; Arner, Douglas; Buckley, Ross et al

E-print/Working paper (2020)

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See detailThe Regulation on European Long-Term Investment Funds (ELTIFR), sustainability and the AIFMD
Zetzsche, Dirk Andreas UL; Preiner, Christina

in The AIFM Directive (2020)

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See detail§ 53 WpHG betreffend die Überwachung von Leerverkäufen
Zetzsche, Dirk Andreas UL; Lehmann, M.

in Kapitalmarktrechtskommentar (2020)

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See detailThe effect of a syntactic training on multilingual fifth graders' spelling patterns of noun capitalization in German
Bilici, Natalia UL; Ugen, Sonja UL; Weth, Constanze UL

in Writing Systems Research (2020), 11(2), 95-109

Silent orthographic syntactic markers, such as capitalisation of nouns in German are prone to error throughout schooling. The present study explores the spelling patterns related to capitalisation in ... [more ▼]

Silent orthographic syntactic markers, such as capitalisation of nouns in German are prone to error throughout schooling. The present study explores the spelling patterns related to capitalisation in multilingual pupils with German as a second language and investigates the efficiency of a syntax-based teaching approach of capitalisation for pupils’ spelling performance (n = 246). The results show, firstly, that pupils with German as a second language show similar capitalisation patterns influenced by lexico-semantic and positional factors as pupils with German as a first language. Secondly, the results suggest that a syntax-based teaching approach to capitalisation of nouns is highly effective especially for nominalizations. The study supports the assumption that stimulating pupils’ attention to syntactic structures is beneficial for spelling when these features are represented clearly and regularly in the writing system, but not in phonology. [less ▲]

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See detailTesting association of rare genetic variants with resistance to three common antiseizure medications
Wolking, Stefan; Moreau, Claudia; Nies, Anne T. et al

in Epilepsia (2020), 61(n/a), 657-666

Abstract Objective Drug resistance is a major concern in the treatment of individuals with epilepsy. No genetic markers for resistance to individual antiseizure medication (ASM) have yet been identified ... [more ▼]

Abstract Objective Drug resistance is a major concern in the treatment of individuals with epilepsy. No genetic markers for resistance to individual antiseizure medication (ASM) have yet been identified. We aimed to identify the role of rare genetic variants in drug resistance for three common ASMs: levetiracetam (LEV), lamotrigine (LTG), and valproic acid (VPA). Methods A cohort of 1622 individuals of European descent with epilepsy was deeply phenotyped and underwent whole exome sequencing (WES), comprising 575 taking LEV, 826 LTG, and 782 VPA. We performed gene- and gene set–based collapsing analyses comparing responders and nonresponders to the three drugs to determine the burden of different categories of rare genetic variants. Results We observed a marginally significant enrichment of rare missense, truncating, and splice region variants in individuals who were resistant to VPA compared to VPA responders for genes involved in VPA pharmacokinetics. We also found a borderline significant enrichment of truncating and splice region variants in the synaptic vesicle glycoprotein (SV2) gene family in nonresponders compared to responders to LEV. We did not see any significant enrichment using a gene-based approach. Significance In our pharmacogenetic study, we identified a slightly increased burden of damaging variants in gene groups related to drug kinetics or targeting in individuals presenting with drug resistance to VPA or LEV. Such variants could thus determine a genetic contribution to drug resistance. [less ▲]

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See detailDigital Finance & The COVID-19 Crisis
Zetzsche, Dirk Andreas UL; Arner, Douglas; Barberis, Janos Nathan et al

E-print/Working paper (2020)

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See detailInfrastructure Investments under AIFMD
Zetzsche, Dirk Andreas UL; Yeboah-Smith, Miko UL; Dornseifer, F.

in The AIFM Directive (2020)

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