References of "2018"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailIncluding gaming disorder in the ICD-11: The need to do so from a clinical and public health perspective.
Rumpf, Hans-Jurgen; Achab, Sophia; Billieux, Joël UL et al

in Journal of behavioral addictions (2018), 7(3), 556-561

The proposed introduction of gaming disorder (GD) in the 11th revision of the International Classification of Diseases (ICD-11) developed by the World Health Organization (WHO) has led to a lively debate ... [more ▼]

The proposed introduction of gaming disorder (GD) in the 11th revision of the International Classification of Diseases (ICD-11) developed by the World Health Organization (WHO) has led to a lively debate over the past year. Besides the broad support for the decision in the academic press, a recent publication by van Rooij et al. (2018) repeated the criticism raised against the inclusion of GD in ICD-11 by Aarseth et al. (2017). We argue that this group of researchers fails to recognize the clinical and public health considerations, which support the WHO perspective. It is important to recognize a range of biases that may influence this debate; in particular, the gaming industry may wish to diminish its responsibility by claiming that GD is not a public health problem, a position which maybe supported by arguments from scholars based in media psychology, computer games research, communication science, and related disciplines. However, just as with any other disease or disorder in the ICD-11, the decision whether or not to include GD is based on clinical evidence and public health needs. Therefore, we reiterate our conclusion that including GD reflects the essence of the ICD and will facilitate treatment and prevention for those who need it. [less ▲]

Detailed reference viewed: 118 (0 UL)
Full Text
Peer Reviewed
See detailA roadmap towards personalized immunology.
Delhalle, Sylvie; Bode, Sebastian F. N.; Balling, Rudi UL et al

in NPJ systems biology and applications (2018), 4

Big data generation and computational processing will enable medicine to evolve from a "one-size-fits-all" approach to precise patient stratification and treatment. Significant achievements using "Omics ... [more ▼]

Big data generation and computational processing will enable medicine to evolve from a "one-size-fits-all" approach to precise patient stratification and treatment. Significant achievements using "Omics" data have been made especially in personalized oncology. However, immune cells relative to tumor cells show a much higher degree of complexity in heterogeneity, dynamics, memory-capability, plasticity and "social" interactions. There is still a long way ahead on translating our capability to identify potentially targetable personalized biomarkers into effective personalized therapy in immune-centralized diseases. Here, we discuss the recent advances and successful applications in "Omics" data utilization and network analysis on patients' samples of clinical trials and studies, as well as the major challenges and strategies towards personalized stratification and treatment for infectious or non-communicable inflammatory diseases such as autoimmune diseases or allergies. We provide a roadmap and highlight experimental, clinical, computational analysis, data management, ethical and regulatory issues to accelerate the implementation of personalized immunology. [less ▲]

Detailed reference viewed: 122 (2 UL)
See detailAMBIVALENCE TOWARD PARENTS DURING THE PROCESS OF INDIVIDUATION: Being Caught Between Autonomy and Relatedness?
Albert, Isabelle UL; Ferring, Dieter UL

in Albert, Isabelle; Abbey, Emily; Valsiner, Jaan (Eds.) Trans-generational family relations: investigating ambivalences (2018)

The concept of ambivalence has gained considerable research interest in the last years in the study of intergenerational relationships. Lüscher and colleagues (2010) define the experience of ambivalence ... [more ▼]

The concept of ambivalence has gained considerable research interest in the last years in the study of intergenerational relationships. Lüscher and colleagues (2010) define the experience of ambivalence as an oscillation between (temporarily or permanently) irreconcilable, contradictory emotions, thoughts, wishes, and behavioral tendencies that individuals may experience in identity- and agency-relevant social relationships. Such dynamics can include simultaneous conflicting tendencies of “autonomy and dependence,” “freedom and control,” or “closeness and distance” (Lüscher & Hoff, 2013). Because intergenerational family relations are in general relatively close over the whole lifespan and not easily dissolvable, they are—according to these authors—particularly predisposed to experiences of ambivalence. In the present chapter, we concentrate on the link between perceived parental behavior and the experience of ambivalence toward parents in adolescence and emerging adulthood. [less ▲]

Detailed reference viewed: 83 (2 UL)
See detailTranscending ambivalence: Overcoming the ambiguity of theory and practices
Valsiner, Jaan UL; Albert, Isabelle UL; Abbey, Emily

in Albert, Isabelle; Abbey, Emily; Valsiner, Jaan (Eds.) Trans-generational family relations: investigating ambivalences (2018)

Ambivalence is a deeply ambiguous concept. Contributions to the present book, viewed all together, exemplify that verdict, as they are situated in the intellectual space among theory, phenomena, research ... [more ▼]

Ambivalence is a deeply ambiguous concept. Contributions to the present book, viewed all together, exemplify that verdict, as they are situated in the intellectual space among theory, phenomena, research practices, and basic assumptions about the world... [less ▲]

Detailed reference viewed: 74 (1 UL)
Full Text
Peer Reviewed
See detailCommunity-driven roadmap for integrated disease maps.
Ostaszewski, Marek UL; Gebel, Stephan UL; Kuperstein, Inna et al

in Briefings in bioinformatics (2018)

The Disease Maps Project builds on a network of scientific and clinical groups that exchange best practices, share information and develop systems biomedicine tools. The project aims for an integrated ... [more ▼]

The Disease Maps Project builds on a network of scientific and clinical groups that exchange best practices, share information and develop systems biomedicine tools. The project aims for an integrated, highly curated and user-friendly platform for disease-related knowledge. The primary focus of disease maps is on interconnected signaling, metabolic and gene regulatory network pathways represented in standard formats. The involvement of domain experts ensures that the key disease hallmarks are covered and relevant, up-to-date knowledge is adequately represented. Expert-curated and computer readable, disease maps may serve as a compendium of knowledge, allow for data-supported hypothesis generation or serve as a scaffold for the generation of predictive mathematical models. This article summarizes the 2nd Disease Maps Community meeting, highlighting its important topics and outcomes. We outline milestones on the roadmap for the future development of disease maps, including creating and maintaining standardized disease maps; sharing parts of maps that encode common human disease mechanisms; providing technical solutions for complexity management of maps; and Web tools for in-depth exploration of such maps. A dedicated discussion was focused on mathematical modeling approaches, as one of the main goals of disease map development is the generation of mathematically interpretable representations to predict disease comorbidity or drug response and to suggest drug repositioning, altogether supporting clinical decisions. [less ▲]

Detailed reference viewed: 167 (13 UL)
Full Text
Peer Reviewed
See detailFirst Order Feynman-Kac Formula
Li, Xue-Mei; Thompson, James UL

in Stochastic Processes & Their Applications (2018)

We study the parabolic integral kernel associated with the weighted Laplacian and the Feynman-Kac kernels. For manifold with a pole we deduce formulas and estimates for them and for their derivatives ... [more ▼]

We study the parabolic integral kernel associated with the weighted Laplacian and the Feynman-Kac kernels. For manifold with a pole we deduce formulas and estimates for them and for their derivatives, given in terms of a Gaussian term and the semi-classical bridge. Assumptions are on the Riemannian data. [less ▲]

Detailed reference viewed: 208 (34 UL)
Full Text
Peer Reviewed
See detailTowards a Roadmap for Privacy Technologies and the General Data Protection Regulation : A transatlantic initiative
Schiffner, Stefan UL; Berendt, Bettina; Siil, Triin et al

in Tsouroulas, Nikolaos; Rannenberg, Kai; Medina, Manel (Eds.) proceedings of the Annual Privacy Forum 2018 (2018)

Detailed reference viewed: 239 (20 UL)
Full Text
Peer Reviewed
See detailIuwers zornes unmâze missevellet uns sêre. Legitimität von Maßlosigkeit im mittelalterlichen Erzählkosmos
Bendheim, Amelie UL

in Das Mittelalter (2018), 23(1), 11-28

Ausgehend von den Defiziten bestehender Ansätze zur Beschreibung des Helden in mittelalterlichen Erzählwelten, soll die Maßlosigkeit (unmâze) als neue literaturgeschichtliche Kategorie funktionalisiert ... [more ▼]

Ausgehend von den Defiziten bestehender Ansätze zur Beschreibung des Helden in mittelalterlichen Erzählwelten, soll die Maßlosigkeit (unmâze) als neue literaturgeschichtliche Kategorie funktionalisiert werden. Entgegen der konzeptuellen, binären Typisierung des Protagonisten als ‚Held’ bzw. ‚Ritter’ bildet sie ein flexibles Modell, das relational operiert und damit erlaubt, graduelle Unterscheidungen zwischen den Texten vorzunehmen. Am Beispiel heldenepischen (‚Nibelungenlied’) und romanhaften (‚Flore und Blanscheflur’, ‚Wigalois’) Erzählens im Mittelalter wird gezeigt, wie mit dem maßlosen Helden narrativ umgegangen wird. Dabei liegt der Fokus insbesondere auf der unterschiedlichen Bewertung seines Handelns: Kann sich der Held im Epos über soziale Normen und geltende Gesetze hinwegsetzen (Siegfried bei der Brautwerbung, Hagen mit dem Mord an Siegfried) ohne dafür bestraft zu werden, tritt die Maßlosigkeit im höfischen Roman stärker in den Bereich der Ratio: Sie wird dabei zum einen begrenzt und ‚bemessen’, zum anderen wird maßloses Handeln nun strikt sanktioniert und unterbunden. Unter Bezugnahme auf aktuelle Ausprägungen der Maßlosigkeit im gesellschaftspolitischen Kontext, tritt das Konzept der Maßlosigkeit als unverändert produktives Muster hervor. Seine gesellschaftliche Relevanz regt zu einer epochenübergreifenden literaturgeschichtlichen Inanspruchnahme an, die sich zum Ziel setzt, die Literaturgeschichte als Geschichte der Maßlosigkeit zu neu zu begreifen. [less ▲]

Detailed reference viewed: 189 (3 UL)
Full Text
Peer Reviewed
See detailAn activity theoretical research lens on inquiry-based learning
Max, Charles UL

in de Vries, Marc J.; Fletcher, Stefan; Kruse, Stefan (Eds.) et al Research in Technology Education: International Approaches. (2018)

Inquiry-based learning and instruction with mobile technologies generate tremendous research interest. To what extent do these tools innovate and transform learning processes, shape individual or ... [more ▼]

Inquiry-based learning and instruction with mobile technologies generate tremendous research interest. To what extent do these tools innovate and transform learning processes, shape individual or collaborative explorations of scientific phenomena, facilitate auto-regulated processes, stimulate creative classroom productions, or support the formation of scientific understanding and critical thinking? That’s exactly where this book chapter gets in. It's purpose is to set up an open, theory-based research framework which allows to empirically study inquiry-based learning and teaching practices in technology education (TE). [less ▲]

Detailed reference viewed: 118 (2 UL)
Full Text
Peer Reviewed
See detailA Model for Regulating of Ethical Preferences in Machine Ethics
Baniasadi, Zohreh UL; Parent, Xavier UL; Max, Charles UL et al

in Proceedings of International Conference on Human-Computer Interaction (2018)

Detailed reference viewed: 302 (45 UL)