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See detail"Stroma-induced phenotypic plasticity offers phenotype-specific targeting to improve melanoma treatment".
Seip, Kotryna; Jorgensen, Kjetil; Haselager, Marco Vincent et al

in Cancer letters (2018)

Cancer cells' phenotypic plasticity, promoted by stromal cells, contributes to intra-tumoral heterogeneity and affects response to therapy. We have disclosed an association between fibroblast-stimulated ... [more ▼]

Cancer cells' phenotypic plasticity, promoted by stromal cells, contributes to intra-tumoral heterogeneity and affects response to therapy. We have disclosed an association between fibroblast-stimulated phenotype switching and resistance to the clinically used BRAF inhibitor (BRAFi) vemurafenib in malignant melanoma, revealing a challenge in targeting the fibroblast-induced phenotype. Here we compared molecular features and drug sensitivity in melanoma cells grown as co-cultures with fibroblasts versus mono-cultures. In the presence of fibroblasts, melanoma cells switched to the dedifferentiated, mesenchymal-like, inflammatory phenotype that showed reduced sensitivity to the most of 275 tested cancer drugs. Fibroblasts, however, sensitized melanoma cells to PI3K inhibitors (PI3Ki) and particularly the inhibitor of GSK3, AR-A014418 (GSK3i), that showed superior efficacy in co-cultures. The proteome changes induced by the BRAFi+GSK3i combination mimicked changes induced by BRAFi in mono-cultures, and GSK3i in co-cultures. This suggests that the single drug drives the response to the combination treatment, depending on fibroblast presence or absence, consequently, phenotype. We propose that the BRAFi and GSK3i (or PI3Ki) combination exemplifies phenotype-specific combinatorial treatment that should be beneficial in phenotypically heterogeneous tumors rich in stromal interactions. [less ▲]

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See detailThe Origins of Legal Obligations. Towards a fundamental phenomenology of moral and legal obligation
Van Der Walt, Johan Willem Gous UL

in Matthews, Daniel; Veitch, Scott (Eds.) Law, Obligation, Community (2018)

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See detailBeamforming for Secure Wireless Information and Power Transfer in Terrestrial Networks Coexisting With Satellite Networks
Lin, Zhi; Lin, Min; Ouyang, Jian et al

in IEEE Signal Processing Letters (2018)

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See detailExcitons in few-layer hexagonal boron nitride: Davydov splitting and surface localization
Paleari, Fulvio UL; Galvani, Thomas UL; Amara, Hakim et al

in 2D MATERIALS (2018), 5(4), 045017

Hexagonal boron nitride (hBN) has been attracting great attention because of its strong excitonic effects. Taking into account few-layer systems, we investigate theoretically the effects of the number of ... [more ▼]

Hexagonal boron nitride (hBN) has been attracting great attention because of its strong excitonic effects. Taking into account few-layer systems, we investigate theoretically the effects of the number of layers on quasiparticle energies, absorption spectra, and excitonic states, placing particular focus on the Davydov splitting of the lowest bound excitons. We describe how the inter-layer interaction as well as the variation in electronic screening as a function of layer number N affects the electronic and optical properties. Using both ab initio calculations and a tight-binding model for an effective Hamiltonian describing the excitons, we characterize in detail the symmetry of the excitonic wavefunctions and the selection rules for their coupling to incoming light. We show that for N > 2, one can distinguish between surface excitons that are mostly localized on the outer layers and inner excitons, leading to an asymmetry in the energy separation between split excitonic states. In particular, the bound surface excitons lie lower in energy than their inner counterparts. Additionally, this enables us to show how the layer thickness affects the shape of the absorption spectrum. [less ▲]

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See detailEnergy-Efficient Multicell Multigroup Multicasting With Joint Beamforming and Antenna Selection
Tervo, Oskari; Tran, Le-Nam; Pennanen, Harri et al

in IEEE Transactions on Signal Processing (2018)

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See detail(Reguläre Zeitschriftennummer)
Küpper, Achim UL; Ceuppens, Jan; Leuschner, Torsten et al

in Germanistische Mitteilungen. Zeitschrift für deutsche Sprache, Literatur und Kultur (2018), 44(2), 109-194

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See detailUn nain à la table des géants. Le Grand-Duché de Luxembourg aux origines de l'OTAN
Lafontaine, Aurélia UL

in Hemecht: Zeitschrift für Luxemburger Geschichte (2018), (4), 23-44

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See detailCross-Layer Forward Packet Scheduling for Emerging Precoded Broadband Multibeam Satellite System
Lagunas, Eva UL; Andrenacci, Stefano UL; Chatzinotas, Symeon UL et al

in 9th Advanced Satellite Multimedia Systems Conference (ASMS) and 15th Signal Processing for Space Communications Workshop (SPSC), Berlin, Germany, 10-12 September 2018 (2018)

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See detailEntwicklungen der Trans*-Bewegung in der Bundesrepublik Deutschland
De Silva, Adrian UL

E-print/Working paper (2018)

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See detailEffective Defence Rights in Criminal Proceedings. A European and Comparative Study on judicial remedies
Allegrezza, Silvia UL; Covolo, Valentina UL

Book published by Wolters Kluwer (2018)

The European Union has adopted several Directives harmonising the rights of the suspects and accused persons in criminal proceedings. The effectiveness of defence rights granted by EU legal instruments ... [more ▼]

The European Union has adopted several Directives harmonising the rights of the suspects and accused persons in criminal proceedings. The effectiveness of defence rights granted by EU legal instruments does not simply rely on their correct implementation in national law, but also depends on the existence of enforcement and control mechanisms granting judicial protection to individuals. Although the Directives impose remedial obligations on the Member States, the different structure and scope of judicial control under national law is likely to undermine the justiciability of procedural safeguards granted by EU law. Divergences among national criminal justice systems raise further challenges in the field of cross-border cooperation. In light of the recent case law of the European Courts, the present book explores the scope and meaning of the right to effective judicial protection in criminal proceedings in relation to the first three Directives of the Stockholm roadmap. It offers a comparative analysis of the national implementations of these so-called ABC Directives in six Member States, focusing on legal remedies that ensure the effectiveness of the rights granted by the EU Directives. This volume presents the results of a study carried out by a group of European criminal law experts from 2015 to 2017 thanks to the financial support of the EU Commission. [less ▲]

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See detailBypassing (a lack of) archives: a prosopography approach of the history of the European Court of Justice, 1950s-1970s
Fritz, Vera UL

Presentation (2018)

Ever since its landmark decisions Van Gend en Loos and Costa v. ENEL, the European Court of Justice (ECJ) has played a key role in the so-called ‘constitutionalization’ of the European legal order. The ... [more ▼]

Ever since its landmark decisions Van Gend en Loos and Costa v. ENEL, the European Court of Justice (ECJ) has played a key role in the so-called ‘constitutionalization’ of the European legal order. The fact that its jurisprudence has given EU law a proto-federal framework has been demonstrated, analyzed and commented in countless publications by legal scholars and social scientists, who have tried to grasp how the ECJ could consistently pursue its active prointegration path without provoking a rebellion by the Member States. In the historiography of the EU, however, the ECJ was for many decades largely absent. The main reason for this absence is the Court’s long-standing lack of willingness to give researchers access to its archives. It was only in 2016, that the first archival documents from the ECJ were made available to the public at the Historical Archives of the European Union in Florence. Long awaited, they reveal little about the functioning of the Court. This paper presents how I have in my research used a prosopographical approach to raise the following challenge: if the ECJ does not (really) let us inside via its archives, can we get inside by studying those who worked at the Court, and above all, the main protagonists behind its case law, the judges? Could an investigation of their social and professional backgrounds, a study of their networks and convictions towards European integration, the analysis of their academic writings and personal papers, give us an unprecedented peak behind the curtains of European judicial decision-making? This presentation shows that (and how) knowing more about the judges reveals a lot about the functioning of the ECJ in the period in which it laid the foundations of the constitutionalization (1950s to 1970s). By providing key insights on the visions that the first generations of judges had on Europe and their role in the European constructions process, it reveals the dynamics that prevailed inside the Court and explains why the bench of judges became outright provocative in the 1970s. The prosopographical approach also brings to the surface new knowledge on the Court’s relationship with the Member States of the European communities. By laying bare why the first and highly decisive European judicial decision-makers were chosen by the governments, the collective biographies give new insights into the Member States’ expectations with regard to the institution and their reaction towards its provocative case law. Finally, the prosopographical approach reveals that the ECJ had a very active political network, which it used to pursue its strategic legal and political interests, and make sure that it would in its jurisprudence not go to a point where it risked being overthrown by the governments. [less ▲]

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See detailThe renormalized volume and uniformisation of conformal structures
Guillarmou, C.; Moroianu, S.; Schlenker, Jean-Marc UL

in Journal de l'institut de mathématiques de Jussieu (2018), 17(4), 853-912

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See detailSelfitis and behavioural addiction: A plea for terminological and conceptual rigour.
Starcevic, Vladan; Billieux, Joël UL; Schimmenti, Adriano

in The Australian and New Zealand journal of psychiatry (2018), 52(10), 919-920

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See detailTargeting prohibitins at the cell surface prevents Th17-mediated autoimmunity.
Buehler, Ulrike; Schulenburg, Katharina; Yurugi, Hajime et al

in The EMBO journal (2018), 37(16),

T helper (Th)17 cells represent a unique subset of CD4(+) T cells and are vital for clearance of extracellular pathogens including bacteria and fungi. However, Th17 cells are also involved in ... [more ▼]

T helper (Th)17 cells represent a unique subset of CD4(+) T cells and are vital for clearance of extracellular pathogens including bacteria and fungi. However, Th17 cells are also involved in orchestrating autoimmunity. By employing quantitative surface proteomics, we found that the evolutionarily conserved prohibitins (PHB1/2) are highly expressed on the surface of both murine and human Th17 cells. Increased expression of PHBs at the cell surface contributed to enhanced CRAF/MAPK activation in Th17 cells. Targeting surface-expressed PHBs on Th17 cells with ligands such as Vi polysaccharide (Typhim vaccine) inhibited CRAF-MAPK pathway, reduced interleukin (IL)-17 expression and ameliorated disease pathology with an increase in FOXP3(+)-expressing Tregs in an animal model for multiple sclerosis (MS). Interestingly, we detected a CD4(+) T cell population with high PHB1 surface expression in blood samples from MS patients in comparison with age- and sex-matched healthy subjects. Our observations suggest a pivotal role for the PHB-CRAF-MAPK signalling axis in regulating the polarization and pathogenicity of Th17 cells and unveil druggable targets in autoimmune disorders such as MS. [less ▲]

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See detailLe texte, le discours et la pratique. Sémiotique, linguistique textuelle et analyse du discours
Colas-Blaise, Marion UL

in Ablali, Achard-Bayle, et alii, Driss, Guy, et alii (Ed.) Texte et discours en confrontation dans l'espace européen (2018)

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See detailVom Sprechen, Denken und Rechnen mit Netzwerken. Eine Skizze der Forschungspraxis in den (Digitalen) Geschichtswissenschaften
During, Marten UL

Presentation (2018)

Die Auseinandersetzung mit der nationalsozialistischen Vergangenheit deutscher Behörden war lange Zeit ein Forschungsdesiderat. Erst im Jahr 2005 begann man mit der Realisierung ministeriell geförderter ... [more ▼]

Die Auseinandersetzung mit der nationalsozialistischen Vergangenheit deutscher Behörden war lange Zeit ein Forschungsdesiderat. Erst im Jahr 2005 begann man mit der Realisierung ministeriell geförderter Forschungsprojekte, die sich dezidiert mit der NS-Belastung deutscher Behörden und ihres Personals beschäftigen. [less ▲]

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See detailPresentation of work in social network analysis
During, Marten UL

Presentation (2018)

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See detailL'effet médiateur de la satisfaction de vie sur les plaintes de santé des adolescents au Luxembourg
Catunda, Carolina UL; Heinz, Andreas UL; Willems, Helmut UL

Scientific Conference (2018)

Dans l’objectif d’examiner la santé et le bien-être subjectif des jeunes en âge scolaire, l’enquête HBSC a été mis en place dans plusieurs pays de l’Europe. L’objectif de cette communication est de rendre ... [more ▼]

Dans l’objectif d’examiner la santé et le bien-être subjectif des jeunes en âge scolaire, l’enquête HBSC a été mis en place dans plusieurs pays de l’Europe. L’objectif de cette communication est de rendre compte de l’impact de la satisfaction de vie sur la santé des adolescents du Luxembourg. Méthode : Pour l’enquête HBSC 2014, la cohorte luxembourgeoise a été menée dans les écoles suivant le curriculum national pendant l’année scolaire 2013 / 2014. Au total, 7 757 élèves âgés de 11 à 18 ans, de 590 classes sélectionnées aléatoirement, ont répondu à un questionnaire en français / allemand distribué par leurs professeurs. Ce questionnaire été composé, entre autre, de l’HBSC Symptom Checklist (HBSC-SCL) pour évaluer les plaintes de santé, de l’échelle de Cantril (1965) pour mesurer la satisfaction de vie, ainsi que de questions sociodémographiques. Résultats : Une régression linéaire par étapes met en avance, en premier lieu, l’effet direct du sexe et de l’âge sur les plaintes de santé : les filles rapportent plus de problèmes de santé que les garçons et les plaintes de santé perçus augmentent avec l’âge. De plus, la satisfaction de vie semble aussi avoir un effet sur les plaintes de santé, dès que cette variable est insérée dans le modèle, l’impact de l’âge et genre diminuent, même s’ils continuent significatifs, ce qui indique une médiation partielle. Conclusion : Ces résultats corroborent les tendances retrouvés dans d’autres pays participants de l’enquête HBSC qui montrent aussi l’impact de l’âge et sexe sur les plaintes de santé perçus. De plus, ces données suggèrent que la satisfaction de vie peut être une clé pour diminuer les nombres des problèmes de santé perçus par les adolescents luxembourgeois. [less ▲]

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See detailEffect of peer versus family support on the life satisfaction of Luxemburgish Adolescents
Catunda, Carolina UL; Heinz, Andreas UL; Willems, Helmut UL

Scientific Conference (2018)

Life satisfaction in youth increases with social support and decreases with age. Adolescence is a period of transition and the amount of time spend with peers increases while with family decreases. This ... [more ▼]

Life satisfaction in youth increases with social support and decreases with age. Adolescence is a period of transition and the amount of time spend with peers increases while with family decreases. This study aims to investigate the mediating effects of family and peer support in the life satisfaction of Luxemburgish adolescents. Methods: The most recent HBSC Luxembourg survey took place in 2014. A total of 7 757 students aged from 11 to 18 years old responded to a questionnaire including the Cantril ladder (1965) to access life satisfaction, the Multidimensional Scale of Perceived Social Support (MSPSS) measuring both peer and family support, as well as socio-demographic questions. Findings: Hierarchical multiple regression analysis indicates the negative effect of age on life satisfaction being partially mediated by family support, but not peer support, despite the strong correlation between both kinds of social support. This is especially true for girls, although their life satisfaction and peer support are lower when compared to boys, the difference regarding family support is not significant. Discussion: Although peer and family support are highly correlated variables, only the latter influences adolescents’ life satisfaction, decreasing the impact of age. As adolescence is a period of transition, the opposite results were expected, with peers being more important with age. Keeping a satisfactory relationship with family seems to play an important role in their life satisfaction. More studies should explore both complimentary kinds of social support. [less ▲]

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