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See detailWealth inequality, frailty, and memory impairment: Is wealthier = healthier true at all older ages?
Leist, Anja UL

Scientific Conference (2018, December)

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See detailLa gouvernance, un enjeu transversal d’Internet au numérique
Musiani, Francesca; Schafer, Valerie UL

in Enjeux numériques (2018), (4),

De la gouvernance d’Internet à celle du Web mais aussi de ses archives, en passant par la gouvernance de Wikipedia, de l’Internet des objets, ou encore, par la neutralité du Net, cette contribution ... [more ▼]

De la gouvernance d’Internet à celle du Web mais aussi de ses archives, en passant par la gouvernance de Wikipedia, de l’Internet des objets, ou encore, par la neutralité du Net, cette contribution témoigne de multiples déclinaisons. Si la gouvernance peut être pensée au pluriel et à plusieurs échelles, de la donnée au « réseau des réseaux », dans cet article, nous montrerons aussi la nuance qu’apporte la notion de « gouvernementalité » pour saisir, en théorie comme en pratique, les manières de faire et d’agir dans les environnements numériques. [less ▲]

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See detailPhase-field predictive model for setting of fresh self-compacting concrete
Huang, Haiqin UL; Zilian, Andreas UL

in Proceedings in Applied Mathematics and Mechanics (2018), 18(1),

The initial setting of fresh concrete is mainly caused by the dissolution of cement grains and the precipitation of calcium-silicate-hydrates during cement hydration. Progressing hydration drives the ... [more ▼]

The initial setting of fresh concrete is mainly caused by the dissolution of cement grains and the precipitation of calcium-silicate-hydrates during cement hydration. Progressing hydration drives the transition from a dense suspension to a porous solid phase. Fresh mixture of self-compacting concrete (SCC) can be considered as a phase-changing multi-component material and can be described as a continuum at the macro scale, interacting with a set of transport-reaction-diffusion processes which in turn are driven by phenomena at the level of the microstructure. This contribution focuses on a predictive model for the setting of fresh SCC where the liquid-solid phase transition is captured by a phase-field variable using the Ginzburg-Landau type free energy function. Hydration-related chemical reactions together with heat and mass transfer are volume coupled with the mechanical behaviour and determined by the environmental conditions. The weak form of the predictive model is discretised using the finite element method and implemented with the FEniCS computational framework. [less ▲]

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See detailOsiris: Hunting for Integer Bugs in Ethereum Smart Contracts
Ferreira Torres, Christof UL; Schütte, Julian; State, Radu UL

in 34th Annual Computer Security Applications Conference (ACSAC ’18), San Juan, Puerto Rico, USA, December 3-7, 2018 (2018, December)

The capability of executing so-called smart contracts in a decentralised manner is one of the compelling features of modern blockchains. Smart contracts are fully fledged programs which cannot be changed ... [more ▼]

The capability of executing so-called smart contracts in a decentralised manner is one of the compelling features of modern blockchains. Smart contracts are fully fledged programs which cannot be changed once deployed to the blockchain. They typically implement the business logic of distributed apps and carry billions of dollars worth of coins. In that respect, it is imperative that smart contracts are correct and have no vulnerabilities or bugs. However, research has identified different classes of vulnerabilities in smart contracts, some of which led to prominent multi-million dollar fraud cases. In this paper we focus on vulnerabilities related to integer bugs, a class of bugs that is particularly difficult to avoid due to some characteristics of the Ethereum Virtual Machine and the Solidity programming language. In this paper we introduce Osiris – a framework that combines symbolic execution and taint analysis, in order to accurately find integer bugs in Ethereum smart contracts. Osiris detects a greater range of bugs than existing tools, while providing a better specificity of its detection. We have evaluated its performance on a large experimental dataset containing more than 1.2 million smart contracts. We found that 42,108 contracts contain integer bugs. Be- sides being able to identify several vulnerabilities that have been reported in the past few months, we were also able to identify a yet unknown critical vulnerability in a couple of smart contracts that are currently deployed on the Ethereum blockchain. [less ▲]

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See detailStrategic conversations under imperfect information: Epistemic Message Exchange games
Asher, Nicholas; Paul, Soumya UL

in Journal of Logic, Language and Information (2018), 27(4), 343-385

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See detailIdentifier, contrôler, réprimer. L'impact de 14-18 sur la circulation des personnes
Scuto, Denis UL

in Mutations. Mémoires et Perspectives du Bassin Minier (2018), 10

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See detailHealth access and wealth: Does capital structure matter?
Paccoud, Ivana; Leist, Anja UL

Scientific Conference (2018, December)

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See detailRecent Advances on GNSS Multipath Reflectometry (GNSS-MR) for Sea and Lake Level Studies
van Dam, Tonie UL; Tabibi, Sajad UL; Geremia-Nievinski, F. et al

Scientific Conference (2018, December)

Global navigation satellite system multipath reflectometry (GNSS-MR) has been used to exploit signals of opportunity at L-band for ground-based sea and lake level studies at several locations in the last ... [more ▼]

Global navigation satellite system multipath reflectometry (GNSS-MR) has been used to exploit signals of opportunity at L-band for ground-based sea and lake level studies at several locations in the last few years. Although geodetic-quality antennas are designed to boost the direct transmission from the satellite and to suppress indirect surface reflections, the delay of reflections with respect to the line-of-sight propagation can be used to estimate the water-surface level in a stable terrestrial reference frame. In this contribution, signal-to-noise ratio (SNR) observations from commercial off-the-shelf systems are used to retrieve water level at multiple constellations and modulations. We constrained phase-shifts so as yield more precise reflector heights and further corrected for the tropospheric propagation delays for greater accuracy. We assess GNSS-MR accuracy and precision in two cases. In the first one, using the inversion formal uncertainty and modulation-specific variance factors, reflector heights are combined and converted to water level at hourly epoch spacing and eight-hourly averaging window length. The RMSE between GNSS-MR and tide gauge (TG) records for a single station in the Great Lakes is 1.93 cm for a 12-year period. In the second case, we employ an extended dynamic model, taking tidal velocity and acceleration into account, which is applied for ten stations worldwide. Regression slope between GNSS-MR and TG exhibits a smaller deviation from the ideal 1:1 relationship, compared to the conventional dynamic model (with no acceleration). The RMSE between sub-hourly GNSS-MR and TG is 1.98 cm, with 0.998 correlation coefficient. Tidal constituents agree at the sub-mm level between GNSS-MR and TG. [less ▲]

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See detailA Family of Lightweight Twisted Edwards Curves for the Internet of Things
Ghatpande, Sankalp UL; Groszschädl, Johann UL; Liu, Zhe UL

in Blazy, Olivier; Yeun, Chan Y. (Eds.) Information Security Theory and Practice, 12th IFIP WG 11.2 International Conference, WISTP 2018, Brussels, Belgium, December 10-11, 2018, Proceedings (2018, December)

We introduce a set of four twisted Edwards curves that satisfy common security requirements and allow for fast implementations of scalar multiplication on 8, 16, and 32-bit processors. Our curves are ... [more ▼]

We introduce a set of four twisted Edwards curves that satisfy common security requirements and allow for fast implementations of scalar multiplication on 8, 16, and 32-bit processors. Our curves are defined by an equation of the form -x^2 + y^2 = 1 + dx^2y^2 over a prime field Fp, where d is a small non-square modulo p. The underlying prime fields are based on "pseudo-Mersenne" primes given by p = 2^k - c and have in common that p is congruent to 5 modulo 8, k is a multiple of 32 minus 1, and c is at most eight bits long. Due to these common features, our primes facilitate a parameterized implementation of the low-level arithmetic so that one and the same arithmetic function is able to process operands of different length. Each of the twisted Edwards curves we introduce in this paper is birationally equivalent to a Montgomery curve of the form -(A+2)y^2 = x^3 + Ax^2 + x where 4/(A+2) is small. Even though this contrasts with the usual practice of choosing A such that (A+2)/4 is small, we show that the Montgomery form of our curves allows for an equally efficient implementation of point doubling as Curve25519. The four curves we put forward roughly match the common security levels of 80, 96, 112 and 128 bits. In addition, their Weierstraß representations are isomorphic to curves of the form y^2 = x^3 - 3x + b so as to facilitate inter-operability with TinyECC and other legacy software. [less ▲]

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See detailMotorische Basiskompetenzen Luxemburger Grundschüler und Grundschülerinnen - Ausgewählte Forschungsergebnisse
Scheuer, Claude UL; Bund, Andreas UL

in Luxembourg Center for Educational Testing (LUCET) (Ed.) Nationaler Bildungsbericht (2018)

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See detailHydroxycoumarin OT-55 kills CML cells alone or in synergy with imatinib or Synribo: Involvement of ER stress and DAMP release
Mazumder, A; Lee, JY; Talhi, O et al

in Cancer Letters (2018)

We synthetized and investigated the anti-leukemic potential of the novel cytostatic bis(4-hydroxycoumarin) derivative OT-55 which complied with the Lipinski's rule of 5 and induced differential toxicity ... [more ▼]

We synthetized and investigated the anti-leukemic potential of the novel cytostatic bis(4-hydroxycoumarin) derivative OT-55 which complied with the Lipinski's rule of 5 and induced differential toxicity in various chronic myeloid leukemia (CML) cell models. OT-55 triggered ER stress leading to canonical, caspase-dependent apoptosis and release of danger associated molecular patterns. Consequently, OT-55 promoted phagocytosis of OT-55-treated CML cells by both murine and human monocyte-derived macrophages. Moreover, OT-55 inhibited tumor necrosis factor α-induced activation of nuclear factor-кB and produced synergistic effects when used in combination with imatinib to inhibit colony formation in vitro and Bcr-Abl+ patient blast xenograft growth in zebrafish. Furthermore, OT-55 synergized with omacetaxine in imatinib-resistant KBM-5 R cells to inhibit the expression of Mcl-1, triggering apoptosis. In imatinib-resistant K562 R cells, OT-55 triggered necrosis and blocked tumor formation in zebrafish in combination with omacetaxine. [less ▲]

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See detailTest Suite Generation with the Many Independent Objective (MIO) Algorithm
Arcuri, Andrea UL

in Information and Software Technology (2018), 104(December), 195-206

Context: Automatically generating test suites is intrinsically a multi-objective problem, as any of the testing targets (e.g, statements to execute or mutants to kill) is an objective on its own. Test ... [more ▼]

Context: Automatically generating test suites is intrinsically a multi-objective problem, as any of the testing targets (e.g, statements to execute or mutants to kill) is an objective on its own. Test suite generation has peculiarities that are quite different from other more regular optimisation problems. For example, given an existing test suite, one can add more tests to cover the remaining objectives. One would like the smallest number of small tests to cover as many objectives as possible, but that is a secondary goal compared to covering those targets in the first place. Furthermore, the amount of objectives in software testing can quickly become unmanageable, in the order of (tens/hundreds of) thousands, especially for system testing of industrial size systems. Objective: To overcome these issues, different techniques have been proposed, like for example the Whole Test Suite (WTS) approach and the Many-Objective Sorting Algorithm (MOSA). However, those techniques might not scale well to very large numbers of objectives and limited search budgets (a typical case in system testing). In this paper, we propose a novel algorithm, called Many Independent Objective (MIO) algorithm. This algorithm is designed and tailored based on the specific properties of test suite generation. Method: An empirical study was carried out for test suite generation on a series of artificial examples and seven RESTful API web services. The \evo system test generation tool was used, where MIO, MOSA, WTS and random search were compared. Results: The presented MIO algorithm resulted having the best overall performance, but was not the best on all problems. Conclusion: The novel presented MIO algorithm is a step forward in the automation of test suite generation for system testing. However, there are still properties of system testing that can be exploited to achieve even better results. [less ▲]

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See detailWriting in the Age of William IV
Millim, Anne-Marie UL; McCue, Maureen; Butler, Rebecca

in Yearbook of English Studies (2018), 48

This volume explores the literary, cultural, social and political climate in Britain during the reign of William IV (1830–37). Rarely discussed by scholars searching to define the ‘Romantic’ period, and ... [more ▼]

This volume explores the literary, cultural, social and political climate in Britain during the reign of William IV (1830–37). Rarely discussed by scholars searching to define the ‘Romantic’ period, and overshadowed by Queen Victoria, William IV’s reign signifies an important moment within the long nineteenth century, one whose literary output is marked by experimentation and generic instability. Rather than simply blurring the boundaries between the Romantic and Victorian periods, this diverse collection of essays demonstrates how the spirit of reform, creative experimentation, and an increasingly politically active middle-class readership produced a peculiar literary and material culture of its own. Responding to a wide range of print culture, including periodicals, albums, graphic satires, novels, poetry, travel writing and guidebooks, by canonical and non-canonical authors, such as Catherine Gore, James Hogg, John Ruskin, Mariana Starke, Thomas Hosmer Shepherd and Thomas Pringle, the essays in this volume map a complex network of conversation, personal and national identities, radical and conservative ideologies, and contested domestic and public spaces, both in Britain and abroad. By addressing various aspects of this remarkable period’s material culture and aesthetic innovations, the essays in this collection complicate our contemporary understanding of the long nineteenth century in Britain and open up new spaces for discussion. [less ▲]

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See detail‘No taxation without representation’ or ‘No representation without taxation’? In search of democratic legitimacy for taxation in the post-crisis EU
Pantazatou, Aikaterini UL

in Kritische Vierteljahresschrift für Gesetzgebung und Rechtswissenschaft (2018)

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See detailBildungsungleichheiten im luxemburgischen Sekundarschulsystem aus zeitlicher Perspektive
Hadjar, Andreas UL; Fischbach, Antoine UL; Backes, Susanne UL

in University of Luxembourg, LUCET; Ministère de l’Éducation nationale, de l’Enfance et de la Jeunesse, SCRIPT (Eds.) Nationaler Bildungsbericht Luxemburg 2018 (2018)

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See detailIslamic banking development and access to credit
Leon, Florian UL; Weill, Laurent

in Pacific-Basin Finance Journal (2018), 52

The recent expansion of Islamic banks raises questions on its economic implications. The aim of this paper is to investigate the impact of Islamic banking development on access to credit. We combine data ... [more ▼]

The recent expansion of Islamic banks raises questions on its economic implications. The aim of this paper is to investigate the impact of Islamic banking development on access to credit. We combine data from a unique hand-collected database that covers Islamic banks with firm-level data covering developing and emerging countries over the period of 2006 to 2009. We find that Islamic banking development has overall no impact on credit constraints, while banking development and conventional banking development alleviate obstacles to financing. However Islamic banking development exerts a positive impact on access to credit when conventional banking development is low. Hence we support the view that Islamic banking does not overall alleviate obstacles to financing, but it can act as substitute to conventional banking. [less ▲]

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See detailComputational Statistics: Lecture notes and presentation slides
Bisdorff, Raymond UL

Learning material (2018)

The objective of this course is to introduce the students to the R language and environment for statistical computing and graphics (a GNU project). In particular, the course proposes effective data ... [more ▼]

The objective of this course is to introduce the students to the R language and environment for statistical computing and graphics (a GNU project). In particular, the course proposes effective data handling and storage solutions as well as useful operators for calculations on arrays, in particular matrices. A selected collection of intermediate tools for data analysis, graphical facilities for data analysis and display either on-screen or on hard copy will be illustrated from examples of statistical analyses. Finally, the course will by the way acquaint the students with a well-developed, simple and effective programming language which includes conditionals, loops, user-defined recursive functions and input and output facilities. [less ▲]

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See detailManagement of Parkinson’s Disease 20 Years from Now: Towards Digital Health Pathways
Krüger, Rejko UL; Klucken, Jochen; Bloem, Bastiaan et al

in Journal of Parkinson's Disease (2018)

[en] Current best medical treatment for patients with Parkinson’s disease (PD) involves a medical professional who applies state-of-the-art knowledge of diagnostics and treatment— as derived from cohort ... [more ▼]

[en] Current best medical treatment for patients with Parkinson’s disease (PD) involves a medical professional who applies state-of-the-art knowledge of diagnostics and treatment— as derived from cohort studies and clinical trials— to the healthcare process of individual patients. Thus, the much-needed personalization of medicine depends on the abilities, experience and intuition of medical professionals to adjust group-based knowledge to individual decision making. Within 20 years from now, such personal clinical decisions will be largely supported by digital means, also defining a new ecosystem of healthcare often referred to as “digital medicine”. We expect that the next phase of digitalization will include new “digital health pathways”: data-driven personalized decision support that is based on a combination of multimodal data sources, including evidence-based medical knowledge (e.g., clinical guidelines), personal disease profiles (including genetic determinants of disease progression and treatment response), insights into individual disease trajectories (thereby defining subgroups of patients) and individual patients’ needs. Here, we illustrate the potential of this development by sketching the contours of a digitally supported care pathway for gait disability and falls. Such digital health pathways will support the introduction of personalized medicine for PD patients, allowing patients to benefit optimally from individually tailored treatments. This should result in a better quality of life for patients and lower costs for society. [less ▲]

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