References of "2017"
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See detailLe Cvce.eu, une infrastructure numérique
Gabellini, Marco UL

Presentation (2017, December 18)

Présentation des publications numériques sur le processus de la construction européenne analysé dans une perspective transnationale et multidimensionnelle sur le site cvce.eu. Les collections de ... [more ▼]

Présentation des publications numériques sur le processus de la construction européenne analysé dans une perspective transnationale et multidimensionnelle sur le site cvce.eu. Les collections de publications thématiques et le programme d’histoire orale, comprenant près de 100 interviews de personnalités européennes, constituent une approche innovante de la construction européenne. [less ▲]

Detailed reference viewed: 55 (5 UL)
See detailHomotopical Geometry over Differential Operators and Batalin-Vilkovisky Complex
Poncin, Norbert UL

Presentation (2017, December 18)

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See detailBrexit:Options for Banks from the UK to Access the EU Market
Prüm, André UL

in Europäische Zeitschrift für Wirtschaftsrecht = European Journal of Business Law = Revue Européenne de Droit Economique (2017), 24/2017

UK banks who want to maintain an access to the EU market after BREXIT are currently assessing their options. The prospect of a free trade agreement with the EU remaining uncertain, they cannot rely on ... [more ▼]

UK banks who want to maintain an access to the EU market after BREXIT are currently assessing their options. The prospect of a free trade agreement with the EU remaining uncertain, they cannot rely on such an agreement before taking a decision. The present paper sketches the three main options - i.e. servicing EU clients directly from the UK, creating a branch or establishing a subsidiary - comparing their benefits and restrictions under the GATS rules and the free movement of capital and freedom of establishment under the EU Treaties. The focus is on traditional banking activities leaving aside investment services. Whilst acting through a EU based subsidiary appears to be the most promising option for UK banks who ambition to serve clients on a EU scale, the choice of location is not trivial as Member States are competing to attract such subsidiaries to their jurisdiction. The ECB in its supervisory role of the banking sector has already signaled that it will not allow such competition to result in a supervisory arbitrage. [less ▲]

Detailed reference viewed: 137 (4 UL)
See detailexpert meeting Digital Source Criticism
Scagliola, Stefania UL

Presentation (2017, December 18)

this expert meeting was meant to bring scholars together who conduct research on the topic of digital hermeneutics and digital source criticism, to exchange their views on the interpretation of this ... [more ▼]

this expert meeting was meant to bring scholars together who conduct research on the topic of digital hermeneutics and digital source criticism, to exchange their views on the interpretation of this concept. [less ▲]

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See detailThe Empirical Saddlepoint Estimator
Holcblat, Benjamin UL; Sowell, Fallaw

Scientific Conference (2017, December 17)

Previous studies have shown that existing moment-based estimation approaches have poor small-sample performance in some applications. We propose an alternative that is based on the ESP (empirical ... [more ▼]

Previous studies have shown that existing moment-based estimation approaches have poor small-sample performance in some applications. We propose an alternative that is based on the ESP (empirical saddlepoint) approximation of the solutions to the empirical moment conditions. Saddlepoint approximations are known to perform well in small sample. The novel estimator proposed, which we call the ESP estimator, is the mode of the ESP approximation. We show that it is consistent and asymptotically normal, and we study its higher-order bias. We propose novel test statistics based on the ESP estimator. Finally, we also investigate the finite-sample properties of the ESP estimator and related test statistics through Monte-Carlo simulations. [less ▲]

Detailed reference viewed: 87 (7 UL)
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See detailThe Missing Risk Premium in Exchange Rates
Penasse, Julien UL

Scientific Conference (2017, December 15)

Detailed reference viewed: 82 (1 UL)
See detailPanel: Re/Bordering Memory: Dynamics and Frictions of Multi-Scala Remembering
Venken, Machteld UL

Presentation (2017, December 15)

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See detailNASA-FDL Artificial Intelligence in Planetary Science; Lunar Resource Mission
Backes, Dietmar UL

Scientific Conference (2017, December 15)

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See detailThe Material Competence of the European Public Prosecutor's Office (EPPO) and the PIF Directive
Marletta, Angelo UL

in Os novos desafios da cooperação judiciária e policial na União Europeia e da implementação da Procuradoria Europeia (2017)

Detailed reference viewed: 146 (11 UL)
See detailLes regards experts sur l’Est en Allemagne et en Pologne : émergence, cristallisation et révision (1918-1972)
Bunout, Estelle UL

Doctoral thesis (2017)

La 1e Guerre mondiale fut le catalyseur de mutations sociales et techniques, qui suscitent de nouveaux besoins d’administration, matérialisés par l’émergence d’un nouveau groupe social: celui des experts ... [more ▼]

La 1e Guerre mondiale fut le catalyseur de mutations sociales et techniques, qui suscitent de nouveaux besoins d’administration, matérialisés par l’émergence d’un nouveau groupe social: celui des experts. Dans les États modernes allemands et polonais, un groupe particulier d’experts se détache, qui se spécialisent dans une thématique aux profondes racines culturelles : l’Est européen.Les changements de régime et de territoire entre 1918 et 1972 déstabilisent le cadre de référence des sociétés allemandes et polonaises, particulièrement entre 1939 et 1945. Cependant, l’historiographie des sciences de l’Est allemandes (Ostforschung) souligne les continuités personnelles, institutionnelles et conceptuelles fortes dans l’expertise de l’Est du « IIIe Reich » à l’Allemagne de l’Ouest. En Allemagne de l’Est et en Pologne, au contraire, le changement de régime après 1945 rend impossible toute continuité, mais la question de l’évolution de la pensée sur l’Est dans les cercles de l’expertise, qui eux se maintiennent, reste posée.En dépassant l’analyse de l’expertise en termes de subordination aux différents régimes politiques auxquels elle s’adresse, nous mettons en valeur les spécificités de l’expertise de l’Est. Elle se caractérise par un double ancrage dans l’imaginaire collectif et dans les pratiques scientifiques contemporaines, pour exprimer un but politique. Cet ancrage explique l’inertie dans les conceptions allemandes et polonaises de l’Est. L’approche comparatiste souligne tant la diversité des conceptions de l’Est, que les fonctions sociales comparables de l’Est, notamment celle d’ennemi et d’espace de projection nationale, passée et à venir [less ▲]

Detailed reference viewed: 67 (6 UL)
See detailLocalization and role of the molecular scaffold testin during mitosis and in actin-based processes
Mazzacavallo, Coralie UL

Doctoral thesis (2017)

The cytoskeleton is an important system in health and disease. Composed by three major classes of filaments, it ensures the maintaining of the cellular shape, it is involved in cell motility and cell ... [more ▼]

The cytoskeleton is an important system in health and disease. Composed by three major classes of filaments, it ensures the maintaining of the cellular shape, it is involved in cell motility and cell division. The complex regulation of this system is mediated by a various number of proteins which often display multiple and differential functions. Testin is one of these cytoskeletal proteins described in important processes involving the actin cytoskeleton such as cell migration and cell spreading. This thesis is dedicated to the study of testin during the cell division process which is mainly regulated by the actin and microtubule cytoskeleton. Our results provided evidence that, during mitosis, testin is able to dynamically localize to mitotic structures like centrosome, midzone and midbody. Further investigations of this localization, particularly in cytokinesis, permit to conclude that testin is a midbody bulge protein capable to concentrate to this intercellular bridge through its LIM1 and LIM2 domains. Testin is involved in the regulation of the actin cytoskeleton through being part of a protein complex with amongst other zyxin and talin, also able to concentrate to the midbody. Therefore, using RNAi experiments, we showed that the localization of testin to the midbody is zyxin and talin independent. In order to understand the potential function of testin during the cell division process, we initiate the identification of the potential partners of testin during mitosis. Based on the known interactors of testin, themselves described to localize to the midbody, we performed pull down as well as knock-down experiments. We also started the screening of potential mitotic partners of testin using the BioID approach. Given these observations about the localization of testin during mitosis the question arose whether testin plays a role in this process of cell division. Indeed, modulating the expression of testin results in different phenotypes. Overexpression of testin leads in faulty spindle formation or in a lack of abscission thus ultimately to an increase in multinucleated cells. Conversely, down regulation of testin leads to a perturbation of the nuclear shape and the microtubule structure of the midbody. Taken together, these data suggest that, in addition to its important role in actin-based processes in interphase, testin, a novel midbody bulge protein is involved in mitosis where it appears required for the integrity of a microtubule structure. [less ▲]

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See detailTemPsy-Check: a Tool for Model-driven Trace Checking of Pattern-based Temporal Properties
Dou, Wei UL; Bianculli, Domenico UL; Briand, Lionel UL

in Proceedings of RV-CUBES 2017: an International Workshop on Competitions, Usability, Benchmarks, Evaluation, and Standardisation for Runtime Verification Tools (2017, December 14)

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See detailHigher Supergeometry Revisited
Poncin, Norbert UL

Presentation (2017, December 14)

Detailed reference viewed: 178 (52 UL)
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See detailModelling argumentation on Axiom of Choice in ASPIC-END -- Technical report
Cramer, Marcos UL

Report (2017)

In this technical report, we present an application of the structured argumentation methodology to a debate in the foundations of mathematics. We work with ASPIC-END, a recently proposed adaptation of the ... [more ▼]

In this technical report, we present an application of the structured argumentation methodology to a debate in the foundations of mathematics. We work with ASPIC-END, a recently proposed adaptation of the structured argumentation framework ASPIC+ which can incorporate debates about logical principles, natural deduction style arguments and explanations. We apply this framework to build a preliminary formal model of parts of the debate that mathematicians had about the Axiom of Choice in the early 20th century. Furthermore, we briefly discuss the insight into the strengths and drawbacks of the modeling capacities of ASPIC-END that we have gained from producing this model. [less ▲]

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See detailOn the Risk of Tool Over-tuning in Runtime Verification Competitions
Bianculli, Domenico UL; Krstic, Srdan

in Proceedings of RV-CUBES 2017: an International Workshop on Competitions, Usability, Benchmarks, Evaluation, and Standardisation for Runtime Verification Tools (2017, December 14)

Detailed reference viewed: 84 (13 UL)
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See detailThe publishing process and Open Access
England, Jonathan UL

Presentation (2017, December 13)

Series of workshops tailored towards early-career researchers in Luxembourg explaining the publishing process and how Open Access fits in the traditional journal-subscription based model. The idea is to ... [more ▼]

Series of workshops tailored towards early-career researchers in Luxembourg explaining the publishing process and how Open Access fits in the traditional journal-subscription based model. The idea is to break some of the myths around OA (e.g. OA is a journal, OA is only possible the gold way) by presenting the 'Green' (self-archiving) and 'gold' (paying Article Processing Charges) routes. Some of the benefits are presented, along with the main Luxembourgish funder FNR's mandate. The presentation uploaded was given to PhDs and post-docs from the Luxembourg Institute of Health on 13/12/2017. [less ▲]

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See detailResolving the Combinatorial Complexity of Smad Protein Complex Formation and Its Link to Gene Expression.
Lucarelli, Philippe UL; Schilling, Marcel; Kreutz, Clemens et al

in Cell Systems (2017)

Upon stimulation of cells with transforming growth factor beta (TGF-beta), Smad proteins form trimeric complexes and activate a broad spectrum of target genes. It remains unresolved which of the possible ... [more ▼]

Upon stimulation of cells with transforming growth factor beta (TGF-beta), Smad proteins form trimeric complexes and activate a broad spectrum of target genes. It remains unresolved which of the possible Smad complexes are formed in cellular contexts and how these contribute to gene expression. By combining quantitative mass spectrometry with a computational selection strategy, we predict and provide experimental evidence for the three most relevant Smad complexes in the mouse hepatoma cell line Hepa1-6. Utilizing dynamic pathway modeling, we specify the contribution of each Smad complex to the expression of representative Smad target genes, and show that these contributions are conserved in human hepatoma cell lines and primary hepatocytes. We predict, based on gene expression data of patient samples, increased amounts of Smad2/3/4 proteins and Smad2 phosphorylation as hallmarks of hepatocellular carcinoma and experimentally verify this prediction. Our findings demonstrate that modeling approaches can disentangle the complexity of transcription factor complex formation and its impact on gene expression. [less ▲]

Detailed reference viewed: 127 (3 UL)
See detailHealth Behaviour in School-aged Children - Studienergebnisse der HBSC-Erhebung 2014
Heinz, Andreas UL

Scientific Conference (2017, December 13)

Detailed reference viewed: 74 (1 UL)