![]() ; Thiele, Ines ![]() in Frontiers in Genetics (2016) Detailed reference viewed: 119 (4 UL)![]() Scuto, Denis ![]() Book published by Fondation Robert Krieps (2016) Detailed reference viewed: 242 (20 UL)![]() Tournier, Isabelle ![]() Scientific Conference (2016) Detailed reference viewed: 62 (2 UL)![]() ![]() Tournier, Isabelle ![]() ![]() Poster (2016) Detailed reference viewed: 142 (4 UL)![]() Klump, Rainer ![]() in Macroeconomic Dynamics (2016) Detailed reference viewed: 151 (10 UL)![]() Okawa, Satoshi ![]() ![]() ![]() in Stem Cell Reports (2016) Detailed reference viewed: 499 (106 UL)![]() Grong, Erlend ![]() in SIAM Journal on Control and Optimization (2016), 54(2), 536-566 Given a submersion $\pi:Q \to M$ with an Ehresmann connection~$\calH$, we describe how to solve Hamiltonian systems on $M$ by lifting our problem to $Q$. Furthermore, we show that all solutions of these ... [more ▼] Given a submersion $\pi:Q \to M$ with an Ehresmann connection~$\calH$, we describe how to solve Hamiltonian systems on $M$ by lifting our problem to $Q$. Furthermore, we show that all solutions of these lifted Hamiltonian systems can be described using the original Hamiltonian vector field on $M$ along with a generalization of the magnetic force. This generalized force is described using the curvature of $\calH$ along with a new form of parallel transport of covectors vanishing on $\calH$. Using the Pontryagin Maximum Principle, we apply this theory to optimal control problems $M$ and $Q$ to get results on normal and abnormal extremals. We give a demonstration of our theory by considering the optimal control problem of one Riemannian manifold rolling on another without twisting or slipping along curves of minimal length. [less ▲] Detailed reference viewed: 126 (8 UL)![]() Haraldsdottir, Hulda ![]() ![]() in PLoS Computational Biology (2016) Detailed reference viewed: 134 (0 UL)![]() ![]() Heimböckel, Dieter ![]() in Beck, Laura; Osthues, Julian (Eds.) Postkolonialismus und (Inter-)Medialität. Perspektiven der Grenzüberschreitung im Spannungsfeld von Literatur, Musik, Fotografie, Theater und Film (2016) Detailed reference viewed: 161 (0 UL)![]() ![]() ; ; Decieux, Jean Philippe Pierre ![]() in Gürlevik, Aydin; Hurrelmann, Klaus; Palentien, Christian (Eds.) Jugend und Politik: Politische Bildung und Beteiligung von Jugendlichen (2016) Detailed reference viewed: 339 (16 UL)![]() Glaab, Enrico ![]() Presentation (2016) Public transcriptomic studies have shown that several genes display pronounced gender differences in their expression in the human brain, which may influence the manifestations and risk for neuronal ... [more ▼] Public transcriptomic studies have shown that several genes display pronounced gender differences in their expression in the human brain, which may influence the manifestations and risk for neuronal disorders. Here, we apply a transcriptome-wide analysis to discover genes with gender-specific expression and significant alterations in public postmortem brain tissue from Alzheimer’s disease (AD) patients compared to controls. We identify the sex-linked ubiquitin-specific peptidase 9 (USP9) as an outstanding candidate gene with highly significant expression differences between the genders and male-specific underexpression in AD. Since previous studies have shown that USP9 can modulate the phosphorylation of the AD-associated protein MAPT, we investigate functional associations between USP9 and MAPT in further detail. After observing a high positive correlation between the expression of USP9 and MAPT in the public transcriptomics data, we show that USP9 knockdown results in significantly decreased MAPT expression in a DU145 cell culture model and a concentration-dependent decrease for the MAPT orthologs mapta and maptb in a zebrafish model. From the analysis of microarray and qRT-PCR experiments for the knockdown in DU145 cells and prior knowledge from the literature, we derive a data-congruent model for a USP9-dependent regulatory mechanism modulating MAPT expression via BACH1 and SMAD4. Overall, the analyses suggest USP9 may contribute to molecular gender differences observed in tauopathies and provide a new target for intervention strategies to modulate MAPT expression. [less ▲] Detailed reference viewed: 164 (7 UL)![]() Glauner, Patrick ![]() in Proceedings of the Seventh IEEE Conference on Innovative Smart Grid Technologies (ISGT 2016) (2016) Non-technical losses (NTL) such as electricity theft cause significant harm to our economies, as in some countries they may range up to 40% of the total electricity distributed. Detecting NTLs requires ... [more ▼] Non-technical losses (NTL) such as electricity theft cause significant harm to our economies, as in some countries they may range up to 40% of the total electricity distributed. Detecting NTLs requires costly on-site inspections. Accurate prediction of NTLs for customers using machine learning is therefore crucial. To date, related research largely ignore that the two classes of regular and non-regular customers are highly imbalanced, that NTL proportions may change and mostly consider small data sets, often not allowing to deploy the results in production. In this paper, we present a comprehensive approach to assess three NTL detection models for different NTL proportions in large real world data sets of 100Ks of customers: Boolean rules, fuzzy logic and Support Vector Machine. This work has resulted in appreciable results that are about to be deployed in a leading industry solution. We believe that the considerations and observations made in this contribution are necessary for future smart meter research in order to report their effectiveness on imbalanced and large real world data sets. [less ▲] Detailed reference viewed: 173 (10 UL)![]() Gatti, Mauro ![]() in European Law Journal (2016) Detailed reference viewed: 108 (0 UL)![]() Gatti, Mauro ![]() in Hesselman, Marlies; Hallo de Wolf, Antenor; Toebes, Brigit (Eds.) Socio-Economic Human Rights in Essential Public Services Provision (2016) Detailed reference viewed: 103 (2 UL)![]() Gatti, Mauro ![]() in Lundt, Bea; Wulk, Sophie (Eds.) Global Perspectives on Europe: Critical spotlights from five continents (2016) Detailed reference viewed: 120 (5 UL)![]() ; ; et al in Nucleic Acids Research (2016) Deep phenotyping has been defined as the precise and comprehensive analysis of phenotypic abnormalities in which the individual components of the phenotype are observed and described. The three components ... [more ▼] Deep phenotyping has been defined as the precise and comprehensive analysis of phenotypic abnormalities in which the individual components of the phenotype are observed and described. The three components of the Human Phenotype Ontology (HPO; www.human-phenotype-ontology.org) project are the phenotype vocabulary, disease-phenotype annotations and the algorithms that operate on these. These components are being used for computational deep phenotyping and precision medicine as well as integration of clinical data into translational research. The HPO is being increasingly adopted as a standard for phenotypic abnormalities by diverse groups such as international rare disease organizations, registries, clinical labs, biomedical resources, and clinical software tools and will thereby contribute toward nascent efforts at global data exchange for identifying disease etiologies. This update article reviews the progress of the HPO project since the debut Nucleic Acids Research database article in 2014, including specific areas of expansion such as common (complex) disease, new algorithms for phenotype driven genomic discovery and diagnostics, integration of cross-species mapping efforts with the Mammalian Phenotype Ontology, an improved quality control pipeline, and the addition of patient-friendly terminology. [less ▲] Detailed reference viewed: 222 (1 UL)![]() Roelens, Nathalie ![]() in Lire, écrire, pratiquer la ville (2016) Detailed reference viewed: 98 (5 UL)![]() van der Torre, Leon ![]() in Dagstuhl Reports (2016) This report documents the program and the outcomes of Dagstuhl Perspectives Workshop 15362 “Present and Future of Formal Argumentation”. The goal of this Dagstuhl Perspectives Workshop was to gather the ... [more ▼] This report documents the program and the outcomes of Dagstuhl Perspectives Workshop 15362 “Present and Future of Formal Argumentation”. The goal of this Dagstuhl Perspectives Workshop was to gather the world leading experts in formal argumentation in order to develop a SWOT (Strength, Weaknesses, Opportunities, Threats) analysis of the current state of the research in this field and to draw accordingly some strategic lines to ensure its successful development in the future. A critical survey of the field has been carried out through individual presentations and collective discussions. Moreover, working group activity lead to identify several open problems in argumentation. [less ▲] Detailed reference viewed: 136 (11 UL)![]() ; ; et al in SCRIPT; LUCET (Eds.) PISA 2015. Nationaler Bericht Luxemburg (2016) Detailed reference viewed: 107 (9 UL)![]() Baudson, Tanja Gabriele ![]() Book published by Karg-Stiftung (2016) Detailed reference viewed: 106 (1 UL) |
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