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See detailPossessions en prêt au Haut Moyen Âge des Abbayes de Gorze et Wissembourg, de 661 à environ 860
Kasten, Brigitte; Schäfer, Jens; Helfer, Malte UL et al

E-print/Working paper (2016)

In the medieval world, the abbey had multiple meanings. On the one hand, it was a place of spiritual life where the abbey community lived, prayed and worked according to the strict ideals of the rule. The ... [more ▼]

In the medieval world, the abbey had multiple meanings. On the one hand, it was a place of spiritual life where the abbey community lived, prayed and worked according to the strict ideals of the rule. The schools, libraries and scriptoriums in which manuscripts were copied and partially decorated, also made it a centre of learning and the spread of knowledge. On the other hand, the abbeys were one of the largest landowners in the Middle Ages and their abbots were not only the superiors of religious communities but also the directors of large economic centres. The endowments for their foundation and donations from royalty or nobility provided the abbeys with considerable property. These assets were by no means a coherent mass in the vicinity of the abbey, but were rather scattered over long distances. The abbeys of Wissembourg and Gorze, through the cartularies that have come down to us, lend themselves to a more precise examination of the abbeys' economy. [less ▲]

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See detailSkin microbiome in melanomas and melanocytic nevi
Salava, A.; Aho, Velma UL; Pereira, P. et al

in European Journal of Dermatology (2016), 26(1), 49-55

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See detailSites du patrimoine mondial de l'UNESCO dans la Grande Région SaarLorLux
Mendgen, Eva; Helfer, Malte UL; Pauly, Michel UL et al

E-print/Working paper (2016)

In 2017, the Greater Region SaarLorLux has no less than twelve sites on the UNESCO World Heritage List. They date from different periods, from prehistory to the beginning of the 20th century, and belong ... [more ▼]

In 2017, the Greater Region SaarLorLux has no less than twelve sites on the UNESCO World Heritage List. They date from different periods, from prehistory to the beginning of the 20th century, and belong to different categories. Architectural and industrial monuments are part of the Greater Region's World Cultural Heritage, as are squares and entire cities, fortifications and cultural landscapes. The World Heritage sites bear witness to the rich European history and are a sign of the Greater Region's exceptional cultural diversity. They are also exceptionally beautiful and picturesque. Each of the World Heritage Sites is related to many other monuments, while providing its own context, history and spatial, cultural and social coordination system. In recent years, global and transnational aspects have gradually led to the listing of ensembles of sites and cultural landscapes. [less ▲]

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See detailSources and Functions of Extracellular Small RNAs in Human Circulation.
Fritz, Joëlle UL; Heintz, Anna UL; Ghosal, Anubrata et al

in Annual review of nutrition (2016)

Various biotypes of endogenous small RNAs (sRNAs) have been detected in human circulation, including microRNAs, transfer RNAs, ribosomal RNA, and yRNA fragments. These extracellular sRNAs (ex-sRNAs) are ... [more ▼]

Various biotypes of endogenous small RNAs (sRNAs) have been detected in human circulation, including microRNAs, transfer RNAs, ribosomal RNA, and yRNA fragments. These extracellular sRNAs (ex-sRNAs) are packaged and secreted by many different cell types. Ex-sRNAs exhibit differences in abundance in several disease states and have, therefore, been proposed for use as effective biomarkers. Furthermore, exosome-borne ex-sRNAs have been reported to elicit physiological responses in acceptor cells. Exogenous ex-sRNAs derived from diet (most prominently from plants) and microorganisms have also been reported in human blood. Essential issues that remain to be conclusively addressed concern the (a) presence and sources of exogenous ex-sRNAs in human bodily fluids, (b) detection and measurement of ex-sRNAs in human circulation, (c) selectivity of ex-sRNA export and import, (d) sensitivity and specificity of ex-sRNA delivery to cellular targets, and (e) cell-, tissue-, organ-, and organism-wide impacts of ex-sRNA-mediated cell-to-cell communication. We survey the present state of knowledge of most of these issues in this review. Expected final online publication date for the Annual Review of Nutrition Volume 36 is July 17, 2016. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates. [less ▲]

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See detailIdentification, recovery, and refinement of hitherto undescribed population-level genomes from the human gastrointestinal tract
Laczny, Cedric Christian UL; Muller, Emilie UL; Heintz, Anna UL et al

in Frontiers in Microbiology (2016), 7(884),

Linking taxonomic identity and functional potential at the population-level is important for the study of mixed microbial communities and is greatly facilitated by the availability of microbial reference ... [more ▼]

Linking taxonomic identity and functional potential at the population-level is important for the study of mixed microbial communities and is greatly facilitated by the availability of microbial reference genomes. While the culture-independent recovery of population-level genomes from environmental samples using the binning of metagenomic data has expanded available reference genome catalogs, several microbial lineages remain underrepresented. Here, we present two reference-independent approaches for the identification, recovery, and refinement of hitherto undescribed population-level genomes. The first approach is aimed at genome recovery of varied taxa and involves multi-sample automated binning using CANOPY CLUSTERING complemented by visualization and human-augmented binning using VIZBINpost hoc. The second approach is particularly well-suited for the study of specific taxa and employs VIZBINde novo. Using these approaches, we reconstructed a total of six population-level genomes of distinct and divergent representatives of the Alphaproteobacteria class, the Mollicutes class, the Clostridiales order, and the Melainabacteria class from human gastrointestinal tract-derived metagenomic data. Our results demonstrate that, while automated binning approaches provide great potential for large-scale studies of mixed microbial communities, these approaches should be complemented with informative visualizations because expert-driven inspection and refinements are critical for the recovery of high-quality population-level genomes. [less ▲]

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See detailNeurological Diseases from a Systems Medicine Point of View.
Ostaszewski, Marek UL; Skupin, Alexander UL; Balling, Rudi UL

in Methods in Molecular Biology (2016), 1386

The difficulty to understand, diagnose, and treat neurological disorders stems from the great complexity of the central nervous system on different levels of physiological granularity. The individual ... [more ▼]

The difficulty to understand, diagnose, and treat neurological disorders stems from the great complexity of the central nervous system on different levels of physiological granularity. The individual components, their interactions, and dynamics involved in brain development and function can be represented as molecular, cellular, or functional networks, where diseases are perturbations of networks. These networks can become a useful research tool in investigating neurological disorders if they are properly tailored to reflect corresponding mechanisms. Here, we review approaches to construct networks specific for neurological disorders describing disease-related pathology on different scales: the molecular, cellular, and brain level. We also briefly discuss cross-scale network analysis as a necessary integrator of these scales. [less ▲]

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See detailOriginal oder Untertitel? Gleich-Berechtigung aller Kunstsparten: Zwei Beispiele
Tropper, Elisabeth UL; Ortmann, Katharina

in Positionen - Texte zur aktuellen Musik (2016), 106

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See detailNormal approximation on Poisson spaces: Mehler's formula, second order Poincaré inequalities and stabilization
Last, Guenter; Peccati, Giovanni UL; Schulte, Matthias

in Probability Theory and Related Fields (2016), 165(3), 667-723

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See detailRPSL meets lightning: A model-based approach to design space exploration of robot perception systems
Gammaitoni, Loïc UL; Hochgeschwender, Nico UL

in RPSL meets lightning: A model-based approach to design space exploration of robot perception systems (2016)

The design space of a robotic application defines at a meta level what are all of its possible implementations. Those possibilities are called design alternatives and differ on many different aspects, one ... [more ▼]

The design space of a robotic application defines at a meta level what are all of its possible implementations. Those possibilities are called design alternatives and differ on many different aspects, one being preferred to the other depending on how, where, when or what the application should do. Design Space Exploration (DSE) is the process of reviewing those design alternatives, prior to their implementation, with intention to verify that the set of all design alternatives to be implemented covers all the possible scenarios in which the application is to be executed. In this paper we address two challenges related to DSE, namely, (1) the formal definitions of design spaces, a non-trivial task due to the many dimensions to be taken into consideration, and (2) the automatisation of DSE, that is, enabling a domain expert to review design alternatives corresponding to a given design space effortlessly. In this paper, we address those challenges in the context of robot perception software systems by combining two already existing technologies, namely RPSL for the specification of robot perception system's design spaces and Lightning, a language workbench that we use to formalise RPSL and obtain, from RPSL specifications, corresponding design alternatives. [less ▲]

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See detailPreventing Coercion in E-Voting: Be Open and Commit
Jamroga, Wojciech UL; Tabatabaei, Masoud UL

in Proceedings of the 12th International Joint Conference on Electronic Voting (E-Vote-ID) (2016)

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See detailExpressing Receipt-Freeness and Coercion-Resistance in Logics of Strategic Ability: Preliminary Attempt
Tabatabaei, Masoud UL; Jamroga, Wojciech UL; Ryan, Peter UL

in The International Workshop on AI for Privacy and Security (PrAISe), 2016. (2016)

Voting is a mechanism of utmost importance to social processes. In this paper, we focus on the strategic aspect of information security in voting procedures. We argue that the notions of receipt-freeness ... [more ▼]

Voting is a mechanism of utmost importance to social processes. In this paper, we focus on the strategic aspect of information security in voting procedures. We argue that the notions of receipt-freeness and coercion resistance are underpinned by existence (or nonexistence) of a suitable strategy for some participants of the voting process. In order to back the argument formally, we provide logical ``transcriptions'' of the informal intuitions behind coercion-related properties that can be found in the existing literature. The transcriptions are formulated in the modal game logic ATL*, well known in the area of multi-agent systems. [less ▲]

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See detailInformation Security as Strategic (In)effectivity
Jamroga, Wojciech UL; Tabatabaei, Masoud UL

in 12th International Workshop on Security and Trust Management (STM), 2016. (2016)

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See detailWechselrahmen : medienhistorische Fallstudien zum Romananfang des 13. Jahrhunderts
Bendheim, Amelie UL

Book published by Winter (2016)

Die Studie unternimmt eine medien- und sozialhistorische Neubeschreibung des Erzählanfangs mittelhochdeutscher Romane. Im Kontext der semi-oralen Rezeptions- und Performanzsituation des Mittelalters ... [more ▼]

Die Studie unternimmt eine medien- und sozialhistorische Neubeschreibung des Erzählanfangs mittelhochdeutscher Romane. Im Kontext der semi-oralen Rezeptions- und Performanzsituation des Mittelalters werden Varianzen in der Überlieferung des Texteingangs nicht als Verderbnis betrachtet, sondern ihnen wird eine kommunikative Funktion zugeschrieben. Anhand detaillierter Einzelanalysen dreier Romane aus dem 13. Jahrhundert (Flore und Blanscheflur, Wigalois, Wigamur) wird die erzähltechnische und rezeptionslenkende Funktion des variablen Anfangsrahmens untersucht, die Rückschlüsse auf die (epochenspezifische) Wahrnehmung von Welt erlaubt. Mit dem textanalytischen Modell des ›Wechselrahmens‹ und der detaillierten Betrachtung paratextueller Elemente eröffnet die Studie neue Perspektiven auf den Erzählanfang als integralen Bestandteil des mittelalterlichen Romans. [less ▲]

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See detailComparing creative profiles: Architects, social scientists and the general population
Kirsch, Christiane UL; Lubart, Todd; Houssemand, Claude UL

in Personality and Individual Differences (2016), 94

The aim of this article is to investigate the hybrid approach of creativity, according to which some features are more domain-general whereas others are more domain-specific. The total sample consisted of ... [more ▼]

The aim of this article is to investigate the hybrid approach of creativity, according to which some features are more domain-general whereas others are more domain-specific. The total sample consisted of 359 participants. The hybrid approach was confirmed. Whereas fluid intelligence had a domain-general importance, the role of ego-strength was very domain-specific. Ego-strength was positively involved in adaptive creativity among student architects but negatively in creativity with the social science students: whereas student architects tended to show a “scientific” creative profile, social science students showed an “artistic” creative profile. Finally, as anticipated, people from the general population demonstrated the expected profile for everyday creativity. [less ▲]

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See detailReified Input/Output logic - a position paper
Robaldo, Livio UL; Sun, Xin UL

in Proceedings of Workshop on Artificial Intelligence for Justice (AI4J), collocated at the 22nd European Conference on Artificial Intelligence (ECAI 2016) (2016)

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See detailSport and Urban Space in Europe: Facilities, Industries, Identities
Terret, Thierry; Heck, Sandra UL

Book published by Routledge (2016)

Filling a gap in the literature on the history of sport in Europe, the book brings together complementary studies on diverse aspects of the interrelation between sport and urban space. Going from ... [more ▼]

Filling a gap in the literature on the history of sport in Europe, the book brings together complementary studies on diverse aspects of the interrelation between sport and urban space. Going from geography to political science, from sports history to urban and transport history, it suggests a three-fold approach. A first thematic group of researches ranges around "Sport Development and Urban Spaces", exploring the impact of the city on the rise of sport. A second focal point is related to "Sport Policies and Local Identities" with a special attention given to the making of sport venues and competitions in the making of urban identity. A third thematic group includes studies on "Sport Facilities, Engineers and Workers". The articulation of the three parts builds a unique contribution to the process of identity making at a European level. [less ▲]

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See detailSystems biology integration of proteomic data in rodent models of depression reveals involvement of the immune response and glutamatergic signalling
Carboni, Lucia; Nguyen, Thanh-Phuong UL; Caberlotto, Laura

in Proteomics. Clinical Applications (2016)

Purpose The pathophysiological basis of major depression is incompletely understood. Recently, numerous proteomic studies have been performed in rodent models of depression to investigate the molecular ... [more ▼]

Purpose The pathophysiological basis of major depression is incompletely understood. Recently, numerous proteomic studies have been performed in rodent models of depression to investigate the molecular underpinnings of depressive-like behaviours with an unbiased approach. The objective of the study was to integrate the results of these proteomic studies in depression models to shed light on the most relevant molecular pathways involved in the disease. Experimental design Network analysis was performed integrating pre-existing proteomic data from rodent models of depression. The IntAct mouse and the HRPD were used as reference protein-protein interaction databases. The functionality analyses of the networks were then performed by testing over-represented GO biological process terms and pathways. Results Functional enrichment analyses of the networks revealed an association with molecular processes related to depression in humans, such as those involved in the immune response. Pathways impacted by clinically effective antidepressants were modulated, including glutamatergic signalling and neurotrophic responses. Moreover, dysregulations of proteins regulating energy metabolism and circadian rhythms were implicated. The comparison with protein pathways modulated in depressive patients revealed significant overlapping. Conclusions and clinical relevance This systems biology study supports the notion that animal models could contribute to the research into the biology and therapeutics of depression. [less ▲]

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See detailTextual Inference with Deep Learning Technique
Adebayo, Kolawole; Di Caro, Luigi; Robaldo, Livio UL et al

in Proceedings of the 28th Annual Benelux Conference on Artificial Intelligence (BNAIC2016). (2016)

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See detailCrossbenching Toward Participation as Critical Spatial Practice
Miessen, Markus UL; Avanessian, Armen; Grassegger, Hannes

Book published by Sternberg Press (2016)

With a preface by Armen Avanessian, an introduction by Hannes Grassegger and Markus Miessen, and a postscript by Patricia Reed “At the heart of this book is a simple and profound proposition: to ‘do’ ... [more ▼]

With a preface by Armen Avanessian, an introduction by Hannes Grassegger and Markus Miessen, and a postscript by Patricia Reed “At the heart of this book is a simple and profound proposition: to ‘do’ architecture is to immerse oneself in a conflictual process of material production—participation is not a productive encounter of multiple practitioners and stakeholders, but a set of conflicts, negotiations, maneuvers, and swindles between and within a multiplicity of agents, human and nonhuman alike—equally including architects, clients, financiers, and builders, say, but also silicon, plastic, concrete, each with its conflicting aims and different material means to achieve them. Every building is thus the materialization of such encounter. So, despite the hubris of the field, none of the parties to such an encounter can ultimately control that the result—architecture (unlike real estate), according to Miessen, belongs to no one but affects and is affected by everyone—and this proposition asks that we reframe questions of ethics and politics. They can no longer be the property of an individual but a collective set of interrelations—it is through such profound departure from the terms of architecture that Miessen’s new book demands nothing less than to reimagine how we might finally become citizens.” —Eyal Weizman, Professor of Spatial and Visual Cultures, Director of the Centre for Research Architecture, Goldsmiths, University of London “Miessen’s new book depicts in a challenging and projective manner the problem of politics in times of conceptual indeterminacy, where ‘participation’ of the civil society seems to become the salvation for the political mess we are in, especially in Europe. Well, it is not! ‘Participation’ will not eradicate the Front National, and more transparency will not deprive Orbán of his power. Civil society will not gain power by criticizing or demonstrating loudly against the European system or chatting on the Internet. The populists have understood that if you want power, you need parties. What we risk to lose in that participatory game is representative democracy in its current shape and for no good: the majority of the street is no democracy. The post-structuralist hype for participation fuels into the mills of those who want to play la volonté de tous against la volonté generale, to go back to Rousseau: yet, the plebs killed Socrates in Athens.“ —Ulrike Guerot, political scientist, founder and director, European Democracy Lab, Berlin [less ▲]

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See detailCrossbenching
Miessen, Markus UL; Avanessian, Armen; Reed, Patricia et al

Book published by Merve (2016)

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