References of "2012"
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See detailFrom Systems Biology to Systems Biomedicine
Antony, Paul UL; Balling, Rudi UL; Vlassis, Nikos UL

in Current Opinion in Biotechnology (2012), 23(4), 604-8

Systems Biology is about combining theory, technology, and targeted experiments in a way that drives not only data accumulation but knowledge as well. The challenge in Systems Biomedicine is to ... [more ▼]

Systems Biology is about combining theory, technology, and targeted experiments in a way that drives not only data accumulation but knowledge as well. The challenge in Systems Biomedicine is to furthermore translate mechanistic insights in biological systems to clinical application, with the central aim of improving patients’ quality of life. The challenge is to find theoretically well-chosen models for the contextually correct and intelligible representation of multiscale biological systems. In this review, we discuss the current state of Systems Biology, highlight the emergence of Systems Biomedicine, and highlight some of the topics and views that we think are important for the efficient application of Systems Theory in Biomedicine. [less ▲]

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See detailÜber die Verschriftlichung der Erinnerung in dem Roman La mémoire de la baleine von Jean Portante
Glesener, Jeanne UL

in Grucza, Franciszek; Neuberg, Simon; Conter, Claude D. (Eds.) et al Jiddische Spache und Literatur / Luxemburgistik / Niederländische Sprach- und Literaturwissenschaft mit besonderer Berücksichtigung des Afrikaans (2012)

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See detailRivaroxaban in patients with a recent acute coronary syndrome.
Mega, Jessica L.; Braunwald, Eugene; Wiviott, Stephen D. et al

in The New England journal of medicine (2012), 366(1), 9-19

BACKGROUND: Acute coronary syndromes arise from coronary atherosclerosis with superimposed thrombosis. Since factor Xa plays a central role in thrombosis, the inhibition of factor Xa with low-dose ... [more ▼]

BACKGROUND: Acute coronary syndromes arise from coronary atherosclerosis with superimposed thrombosis. Since factor Xa plays a central role in thrombosis, the inhibition of factor Xa with low-dose rivaroxaban might improve cardiovascular outcomes in patients with a recent acute coronary syndrome. METHODS: In this double-blind, placebo-controlled trial, we randomly assigned 15,526 patients with a recent acute coronary syndrome to receive twice-daily doses of either 2.5 mg or 5 mg of rivaroxaban or placebo for a mean of 13 months and up to 31 months. The primary efficacy end point was a composite of death from cardiovascular causes, myocardial infarction, or stroke. RESULTS: Rivaroxaban significantly reduced the primary efficacy end point, as compared with placebo, with respective rates of 8.9% and 10.7% (hazard ratio in the rivaroxaban group, 0.84; 95% confidence interval [CI], 0.74 to 0.96; P=0.008), with significant improvement for both the twice-daily 2.5-mg dose (9.1% vs. 10.7%, P=0.02) and the twice-daily 5-mg dose (8.8% vs. 10.7%, P=0.03). The twice-daily 2.5-mg dose of rivaroxaban reduced the rates of death from cardiovascular causes (2.7% vs. 4.1%, P=0.002) and from any cause (2.9% vs. 4.5%, P=0.002), a survival benefit that was not seen with the twice-daily 5-mg dose. As compared with placebo, rivaroxaban increased the rates of major bleeding not related to coronary-artery bypass grafting (2.1% vs. 0.6%, P<0.001) and intracranial hemorrhage (0.6% vs. 0.2%, P=0.009), without a significant increase in fatal bleeding (0.3% vs. 0.2%, P=0.66) or other adverse events. The twice-daily 2.5-mg dose resulted in fewer fatal bleeding events than the twice-daily 5-mg dose (0.1% vs. 0.4%, P=0.04). CONCLUSIONS: In patients with a recent acute coronary syndrome, rivaroxaban reduced the risk of the composite end point of death from cardiovascular causes, myocardial infarction, or stroke. Rivaroxaban increased the risk of major bleeding and intracranial hemorrhage but not the risk of fatal bleeding. (Funded by Johnson & Johnson and Bayer Healthcare; ATLAS ACS 2-TIMI 51 ClinicalTrials.gov number, NCT00809965.). [less ▲]

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See detailÉpreuves Standardisées. Nationaler Bericht 2011‐2012
Martin, Romain UL; Brunner, Martin UL

Book published by University of Luxembourg, EMACS (2012)

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See detailNikolai Neumaier
Bordemann, Martin; Ebrahimi-Fard, Kurusch; Abdenacer, Makhlouf et al

Book published by Fac. Sci. Technol. Commun. Univ. Luxemb., Luxembourg (2012)

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See detailLong-term follow-up of subthalamic nucleus stimulation in glucocerebrosidase-associated Parkinson's disease.
Weiss, Daniel; Brockmann, Kathrin; Srulijes, Karin et al

in Journal of neurology (2012), 259(9), 1970-2

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See detailEast-West Comparisons
Venken, Machteld UL

Presentation (2012)

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See detail« Le portfolio ». Apprendre à travers l’évaluation.
Poncelet, Débora UL

Scientific Conference (2012)

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See detailMoney,
Rasmouki, Fanou UL

Scientific Conference (2012)

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See detailPhilosophy of foreign language teaching within lifelong learning for medical specialists, Dans: et al (eds.), , : ,
Ehrhart, Sabine UL

in MASSARD, Gilbert (Ed.) Life-Long-Lerning Framework for Medical University Teaching Staff. The Collection of Articles (2012)

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See detailSaving Rates and Portfolio Choice with Subsistence Consumption
Koulovatianos, Christos UL; Achury, Carolina; Hubar, Sylwia

in Review of Economic Dynamics (2012), 105(1), 108-126

We analytically show that a common across rich/poor individuals Stone-Geary utility function with subsistence consumption in the context of a simple two-asset portfolio-choice model is capable of ... [more ▼]

We analytically show that a common across rich/poor individuals Stone-Geary utility function with subsistence consumption in the context of a simple two-asset portfolio-choice model is capable of qualitatively and quantitatively explaining: (i) the higher saving rates of the rich, (ii) the higher fraction of personal wealth held in risky assets by the rich, and (iii) the higher volatility of consumption of the wealthier. On the contrary, time-variant "keeping-up-with-the-Joneses" weighted average consumption which plays the role of moving benchmark subsistence consumption gives the same portfolio composition and saving rates across the rich and the poor, failing to reconcile the model with what micro data say. [less ▲]

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See detailA Survey on Intersections of Maximal Partial Clones of Boolean Partial Functions
Couceiro, Miguel UL; Haddad, Lobna

in Multiple-Valued Logic (ISMVL), 2012 42nd IEEE International Symposium on (2012)

We survey known results and present some new ones about intersections of maximal partial clones on a 2-element set.

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See detailPhase II. Einige unpoetische Assoziationen zu einem Rundfunkgespräch zwischen Gotfried Benn und Thilo Koch (1949)
Fickers, Andreas UL

in Roder, Jan (Ed.) Ik woon in duizend kamers tegelijk. Opstellen voor en over Wiel Kusters (2012)

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See detailEntre Attraction et Participation: Une Analyse Comparée du Discours Televisuel aux Expositions Universelles de Paris (1937), New York (1939) et Bruxelles (1958)
Fickers, Andreas UL

in Lugon, Olivier (Ed.) Expositions et Médias: Photograhie, Cinéma, Télévision (2012)

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See detailFiber bundles and connections
Poncin, Norbert UL

E-print/Working paper (2012)

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See detailVisibly Audible. The Radio Dial as Mediating Interface
Fickers, Andreas UL

in Bijsterveld, Karin; Pinch, Trevor (Eds.) Oxford Handbook of Sound Studies (2012)

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See detailMultiscale modeling of metabolism and macromolecular synthesis in E. coli and its application to the evolution of codon usage.
Thiele, Ines UL; Fleming, Ronan MT UL; Que, Richard et al

in PLoS ONE (2012), 7(9), 45635

Biological systems are inherently hierarchal and multiscale in time and space. A major challenge of systems biology is to describe biological systems as a computational model, which can be used to derive ... [more ▼]

Biological systems are inherently hierarchal and multiscale in time and space. A major challenge of systems biology is to describe biological systems as a computational model, which can be used to derive novel hypothesis and drive experiments leading to new knowledge. The constraint-based reconstruction and analysis approach has been successfully applied to metabolism and to the macromolecular synthesis machinery assembly. Here, we present the first integrated stoichiometric multiscale model of metabolism and macromolecular synthesis for Escherichia coli K12 MG1655, which describes the sequence-specific synthesis and function of almost 2000 gene products at molecular detail. We added linear constraints, which couple enzyme synthesis and catalysis reactions. Comparison with experimental data showed improvement of growth phenotype prediction with the multiscale model over E. coli's metabolic model alone. Many of the genes covered by this integrated model are well conserved across enterobacters and other, less related bacteria. We addressed the question of whether the bias in synonymous codon usage could affect the growth phenotype and environmental niches that an organism can occupy. We created two classes of in silico strains, one with more biased codon usage and one with more equilibrated codon usage than the wildtype. The reduced growth phenotype in biased strains was caused by tRNA supply shortage, indicating that expansion of tRNA gene content or tRNA codon recognition allow E. coli to respond to changes in codon usage bias. Our analysis suggests that in order to maximize growth and to adapt to new environmental niches, codon usage and tRNA content must co-evolve. These results provide further evidence for the mutation-selection-drift balance theory of codon usage bias. This integrated multiscale reconstruction successfully demonstrates that the constraint-based modeling approach is well suited to whole-cell modeling endeavors. [less ▲]

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See detailSee-and-Avoid Quadcopter using Fuzzy Control Optimized by Cross-Entropy
Olivares Mendez, Miguel Angel UL; Campoy, Pascual; Mellado-Bataller, Ignacio et al

in See-and-Avoid Quadcopter using Fuzzy Control Optimized by Cross-Entropy (2012)

In this work we present an optimized fuzzy visual servoing system for obstacle avoidance using an unmanned aerial vehicle. The cross-entropy theory is used to optimise the gains of our controllers. The ... [more ▼]

In this work we present an optimized fuzzy visual servoing system for obstacle avoidance using an unmanned aerial vehicle. The cross-entropy theory is used to optimise the gains of our controllers. The optimization process was made using the ROS-Gazebo 3D simulation with purposeful extensions developed for our experiments. Visual servoing is achieved through an image processing front-end that uses the Camshift algorithm to detect and track objects in the scene. Experimental flight trials using a small quadrotor were performed to validate the parameters estimated from simulation. The integration of cross-entropy methods is a straightforward way to estimate optimal gains achieving excellent results when tested in real flights. [less ▲]

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See detailTransnational Television History. A Comparative Approach
Fickers, Andreas UL; Johnson, Cathy

Book published by Routledge (2012)

Detailed reference viewed: 282 (10 UL)