References of "2012"
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See detailXFEM coupling of granular flows interacting with surrounding fluids
Pasenow, F.; Zilian, Andreas UL; Dinkler, D.

in ECCOMAS 2012 - European Congress on Computational Methods in Applied Sciences and Engineering, e-Book Full Papers (2012)

In this paper, ideas for the simulation of sliding dry granular materials interacting with surrounding fluids are presented and first results are presented. The compressible granular material is modeled ... [more ▼]

In this paper, ideas for the simulation of sliding dry granular materials interacting with surrounding fluids are presented and first results are presented. The compressible granular material is modeled as a medium which can show solid-like and fluid-like characteristics. Therefore a weighted decomposition of stress tensors of a solid-like and a fluid-like phase is applied. The surrounding incompressible fluids are described with a Newtonian constitutive model. Interface dynamics are handled with the level-set method. The model equations are discretized with the space-time finite element method. Discontinuous solution characteristics across interfaces are captured numerically by the extended finite element method (XFEM). For all discontinuities the space of ansatz functions is enriched with Heaviside functions. [less ▲]

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See detailDie Grenzgänger. Eine kulturwissenschaftliche Betrachtung
Wille, Christian UL

in Forum für Politik, Gesellschaft und Kultur in Luxemburg (2012), (315), 16-18

Grenzgänger sind ein populäres Thema in Luxemburg und in der Großregion. Dabei handelt es sich jedoch nicht ausschließlich um grenzüberschreitende Arbeitnehmer, sondern Grenzgänger werden zunehmend auch ... [more ▼]

Grenzgänger sind ein populäres Thema in Luxemburg und in der Großregion. Dabei handelt es sich jedoch nicht ausschließlich um grenzüberschreitende Arbeitnehmer, sondern Grenzgänger werden zunehmend auch als Denkfigur in den modernen Kulturwissenschaften entdeckt. Der Beitrag deckt auf, was einen Grenzgänger ausmacht und weshalb sich der Begriff in seinem Facettenreichtum immer größerer Beliebtheit erfreut. [less ▲]

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See detailRationalitätenvielfalt im Kinderschutz - eine Einführung
Bode, Ingo; Marthaler, Thomas UL; Bastian, Pascal et al

in Marthaler, Thomas; Bastian, Pascal; Bode, Ingo (Eds.) et al Rationalitäten des Kinderschutzes. Kindeswohl und soziale Interventionen aus pluraler Perspektive (2012)

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See detailReal Exchange Rates and Skills
Carpantier, Jean-Francois UL

Scientific Conference (2012)

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See detailText erhorchen. Marcel Krings versammelt Beiträge zum „Schallarchiv“ der Literatur
Dembeck, Till UL

in www.literaturkritik.de (2012)

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See detailPanorama des relations extérieures de l’Union européenne dans le domaine de l’énergie
Neframi, Eleftheria UL

in Blumann, Claude (Ed.) Vers une politique de l’énergie de l’Union européenne (2012)

Développement de l'action extérieure de l'Union en matière de l'énergie. L'énergie comme objet et comme volet de l'action extérieure de l'Union. L'efficacité de l'action de l'Union en matière de l'énergie ... [more ▼]

Développement de l'action extérieure de l'Union en matière de l'énergie. L'énergie comme objet et comme volet de l'action extérieure de l'Union. L'efficacité de l'action de l'Union en matière de l'énergie. La poursuite des objectifs énergétiques et la compétence externe de l’Union et des Etats membres. Les objectifs énergétiques et la cohérence de l’action extérieure de l’Union. [less ▲]

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See detailAuslandsverluste und ausländisches Steuerrecht: Neuregelung durch das 1. StabG 2012
Haslehner, Werner UL; Kofler, Georg

in Zeitschrift für Gesellschaftsrecht und angrenzendes Steuerrecht (2012), (7), 9-26

Durch das 1. StabG wurde die Hereinnahme von „befreiten“ Betriebsstättenverlusten und von Verlusten ausländischer Gruppenmitglieder mit dem nach ausländischem Steuerrecht ermittelten Verlustbetrag ... [more ▼]

Durch das 1. StabG wurde die Hereinnahme von „befreiten“ Betriebsstättenverlusten und von Verlusten ausländischer Gruppenmitglieder mit dem nach ausländischem Steuerrecht ermittelten Verlustbetrag gedeckelt. Dadurch soll schon auf Ebene der Verlusthereinnahme das Problem der bisherigen unzureichenden Nachversteuerung gelöst werden, das dadurch entstand, dass der hereinzunehmende Verlust zwar nach inländischem Steuerrecht ermittelt wurde, die Nachversteuerung aber auf die Verlustverwertung nach ausländischem Steuerrecht rekurrierte. Die Neuregelung begegnet allerdings systematischen Bedenken und stellt durch seine Bindung an das ausländische Steuerrecht weiterhin einen Fremdkörper im Ertragsteuersystem dar. Nach einer Vorstellung der bisherigen Problemlage und der Neuregelung soll daher in diesem Beitrag der Versuch unternommen werden, als mögliche Alternative zur nunmehrigen Einschränkung der Verlusthereinnahme eine Nachversteuerungssystem zu entwickeln, das durch das ausschließliche Abstellen auf österreichisches Steuerrecht die bisherigen Probleme sachgerecht und systematisch korrekt lösen würde. [less ▲]

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See detailBayesian Reinforcement Learning
Vlassis, Nikos UL; Ghavamzadeh, Mohammad; Mannor, Shie et al

in Wiering, Marco; van Otterlo, Martijn (Eds.) Reinforcement Learning: State of the Art (2012)

This chapter surveys recent lines of work that use Bayesian techniques for reinforcement learning. In Bayesian learning, uncertainty is expressed by a prior distribution over unknown parameters and ... [more ▼]

This chapter surveys recent lines of work that use Bayesian techniques for reinforcement learning. In Bayesian learning, uncertainty is expressed by a prior distribution over unknown parameters and learning is achieved by computing a posterior distribution based on the data observed. Hence, Bayesian reinforcement learning distinguishes itself from other forms of reinforcement learning by explic- itly maintaining a distribution over various quantities such as the parameters of the model, the value function, the policy or its gradient. This yields several benefits: a) domain knowledge can be naturally encoded in the prior distribution to speed up learning; b) the exploration/exploitation tradeoff can be naturally optimized; and c) notions of risk can be naturally taken into account to obtain robust policies. [less ▲]

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See detailSentiment Trades and Option Prices
Lehnert, Thorsten UL; Frijns, Bart; Zwinkels, Remco

E-print/Working paper (2012)

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See detailSubthalamic nucleus stimulation restores the efferent cortical drive to muscle in parallel to functional motor improvement.
Weiss, Daniel; Breit, Sorin; Hoppe, Julia et al

in The European journal of neuroscience (2012), 35(6), 896-908

Pathological synchronization in large-scale motor networks constitutes a pathophysiological hallmark of Parkinson's disease (PD). Corticomuscular synchronization in PD is pronounced in lower frequency ... [more ▼]

Pathological synchronization in large-scale motor networks constitutes a pathophysiological hallmark of Parkinson's disease (PD). Corticomuscular synchronization in PD is pronounced in lower frequency bands (< 10 Hz), whereas efficient cortical motor integration in healthy persons is driven in the beta frequency range. Electroencephalogram and electromyogram recordings at rest and during an isometric precision grip task were performed in four perioperative sessions in 10 patients with PD undergoing subthalamic nucleus deep-brain stimulation: (i) 1 day before (D0); (ii) 1 day after (D1); (iii) 8 days after implantation of macroelectrodes with stimulation off (D8StimOff); and (iv) on (D8StimOn). Analyses of coherence and phase delays were performed in order to challenge the effects of microlesion and stimulation on corticomuscular coherence (CMC). Additionally, local field potentials recorded from the subthalamic nucleus on D1 allowed comprehensive mapping of motor-related synchronization in subthalamocortical and cerebromuscular networks. Motor performance improved at D8StimOn compared with D0 and D8StimOff paralleled by a reduction of muscular activity and CMC in the theta band (3.9-7.8 Hz) and by an increase of CMC in the low-beta band (13.7-19.5 Hz). Efferent motor cortical drives to muscle presented mainly below 10 Hz on D8StimOff that were suppressed on D8StimOn and occurred on higher frequencies from 13 to 45 Hz. On D1, coherence of the high-beta band (20.5-30.2 Hz) increased during movement compared with rest in subthalamomuscular and corticomuscular projections, whereas it was attenuated in subcorticocortical projections. The present findings lend further support to the concept of pathological network synchronization in PD that is beneficially modulated by stimulation. [less ▲]

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See detailSozial-ökonomische Untersuchungen im Biosphärenreservat Bliesgau. Eine erste Bilanz der Bevölkerungssicht und regionalökonomischer Erfolge.
Lübke, Stephanie; Neumann, Ute; Nienaber, Birte UL et al

in Naturschutz und Landschaftsplanung (2012), 44(11), 333-340

Biosphere reserves are considered as model regions for a sustainable development in which the relations between humans and the environment represent the focal point of research. However, only a few ... [more ▼]

Biosphere reserves are considered as model regions for a sustainable development in which the relations between humans and the environment represent the focal point of research. However, only a few studies dealing with socio-economic questions have been carried out so far. Using the example of the still young Bliesgau biosphere reserve in Saarland, Germany, this contribution gives a first summary of its evaluation by the local population and first successes of the regional economy. The results of a quantitative survey provide information about the population’s awareness of institutions and offers, the disposition to actively participate and the perception of the Bliesgau biosphere reserve. Moreover, factors, which influence these aspects, are emphasized. By examining the regional economy, strengths and deficits, which inform about the regional added value, are pointed out additionally. The enforcement of regional economic cycles represents an important task in the Bliesgau biosphere reserve. Based on these results, our socio-economic studies provide the first basic principles and findings for future research as early as two years after the designation by UNESCO. [less ▲]

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See detailDie Geschichtsforschung zum Handwerk der Stadt Luxemburg im Mittelalter
Jullien, Eva UL

in Hemecht : Zeitschrift für Luxemburger Geschichte = Revue d'Histoire Luxembourgeoise (2012), 64(4), 13-21

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See detailImproving teachers’ judgments: Accountability affects teachers’ tracking decisions
Glock, Sabine UL; Krolak-Schwerdt, Sabine UL; Klapproth, Florian UL et al

in International Journal of Technology and Inclusive Education (2012), 1

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See detailSpecification Patterns from Research to Industry: a Case Study in Service-based Applications
Bianculli, Domenico UL; Ghezzi, Carlo; Pautasso, Cesare et al

in Proceedings of the 34th International Conference on Software Engineering (ICSE 2012) (2012)

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See detailEmergence of the silicon human and network targeting drugs
Kolodkin, Alexey UL; Boogerda, Fred C.; Plantb, Nick et al

in European Journal of Pharmaceutical Sciences (2012), 46(4), 190-197

The development of disease may be characterized as a pathological shift of homeostasis; the main goal of contemporary drug treatment is, therefore, to return the pathological homeostasis back to the ... [more ▼]

The development of disease may be characterized as a pathological shift of homeostasis; the main goal of contemporary drug treatment is, therefore, to return the pathological homeostasis back to the normal physiological range. From the view point of systems biology, homeostasis emerges from the interactions within the network of biomolecules (e.g. DNA, mRNA, proteins), and, hence, understanding how drugs impact upon the entire network should improve their efficacy at returning the network (body) to physiological homeostasis. Large, mechanism-based computer models, such as the anticipated human whole body models (silicon or virtual human), may help in the development of such network-targeting drugs. Using the philosophical concept of weak and strong emergence, we shall here take a more general look at the paradigm of network-targeting drugs, and propose our approaches to scale the strength of strong emergence. We apply these approaches to several biological examples and demonstrate their utility to reveal principles of bio-modeling. We discuss this in the perspective of building the silicon human. [less ▲]

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See detailStochastic POMDP controllers: How easy to optimize?
Vlassis, Nikos UL; Littman, M. L.; Barber, D.

Scientific Conference (2012)

It was recently shown that computing an optimal stochastic controller in a discounted in finite-horizon partially observable Markov decision process is an NP-hard problem. The reduction (from the ... [more ▼]

It was recently shown that computing an optimal stochastic controller in a discounted in finite-horizon partially observable Markov decision process is an NP-hard problem. The reduction (from the independent-set problem) involves designing an MDP with special state-action rewards. In this note, we show that the case of state-only-dependent rewards is also NP-hard. [less ▲]

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See detailFrom Systems Biology to Systems Biomedicine
Antony, Paul UL; Balling, Rudi UL; Vlassis, Nikos UL

in Current Opinion in Biotechnology (2012), 23(4), 604-8

Systems Biology is about combining theory, technology, and targeted experiments in a way that drives not only data accumulation but knowledge as well. The challenge in Systems Biomedicine is to ... [more ▼]

Systems Biology is about combining theory, technology, and targeted experiments in a way that drives not only data accumulation but knowledge as well. The challenge in Systems Biomedicine is to furthermore translate mechanistic insights in biological systems to clinical application, with the central aim of improving patients’ quality of life. The challenge is to find theoretically well-chosen models for the contextually correct and intelligible representation of multiscale biological systems. In this review, we discuss the current state of Systems Biology, highlight the emergence of Systems Biomedicine, and highlight some of the topics and views that we think are important for the efficient application of Systems Theory in Biomedicine. [less ▲]

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