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See detailThe trilingual Luxembourgish school system in historical perspective: progress or regress?
Weber, Jean-Jacques UL; Horner, Kristine

in Language, Culture and Curriculum (2012), 25(1), 3-15

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See detailNon-regenerative Two-Hop Wiretap Channels using Interference Neutralization
Gerbracht, Sabrina; Jorswieck, Eduard A.; Zheng, Gan UL et al

in Information Forensics and Security (WIFS), 2012 IEEE International Workshop on (2012)

In this paper, we analyze the achievable secrecy rates in the two-hop wiretap channel with four nodes, where the transmitter and the receiver have multiple antennas while the relay and the eavesdropper ... [more ▼]

In this paper, we analyze the achievable secrecy rates in the two-hop wiretap channel with four nodes, where the transmitter and the receiver have multiple antennas while the relay and the eavesdropper have only a single antenna each. The relay is operating in amplify-and-forward mode and all the channels between the nodes are known perfectly by the transmitter. We discuss different transmission and protection schemes like artificial noise (AN). Furthermore, we introduce interference neutralization (IN) as a new protection scheme. We compare the different schemes regarding the high-SNR slope and the high-SNR power offset and illustrate the performance by simulation results. It is shown analytically as well as by numerical simulations that the high SNR performance of the proposed IN scheme is better than the one of AN. [less ▲]

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See detailThe Relative Informational Efficiency of Stocks, Options and Credit Default Swaps
Bekkour, Lamia UL

Scientific Conference (2012)

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See detailMutations in the phospholipid remodeling gene SERAC1 impair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness.
Wortmann, Saskia B.; Vaz, Frederic M.; Gardeitchik, Thatjana et al

in Nature genetics (2012), 44(7), 797-802

Using exome sequencing, we identify SERAC1 mutations as the cause of MEGDEL syndrome, a recessive disorder of dystonia and deafness with Leigh-like syndrome, impaired oxidative phosphorylation and 3 ... [more ▼]

Using exome sequencing, we identify SERAC1 mutations as the cause of MEGDEL syndrome, a recessive disorder of dystonia and deafness with Leigh-like syndrome, impaired oxidative phosphorylation and 3-methylglutaconic aciduria. We localized SERAC1 at the interface between the mitochondria and the endoplasmic reticulum in the mitochondria-associated membrane fraction that is essential for phospholipid exchange. A phospholipid analysis in patient fibroblasts showed elevated concentrations of phosphatidylglycerol-34:1 (where the species nomenclature denotes the number of carbon atoms in the two acyl chains:number of double bonds in the two acyl groups) and decreased concentrations of phosphatidylglycerol-36:1 species, resulting in an altered cardiolipin subspecies composition. We also detected low concentrations of bis(monoacyl-glycerol)-phosphate, leading to the accumulation of free cholesterol, as shown by abnormal filipin staining. Complementation of patient fibroblasts with wild-type human SERAC1 by lentiviral infection led to a decrease and partial normalization of the mean ratio of phosphatidylglycerol-34:1 to phosphatidylglycerol-36:1. Our data identify SERAC1 as a key player in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. [less ▲]

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See detailImproving ancient DNA read mapping against modern reference genomes.
Schubert, Mikkel; Ginolhac, Aurélien UL; Lindgreen, Stinus et al

in BMC genomics (2012), 13

BACKGROUND: Next-Generation Sequencing has revolutionized our approach to ancient DNA (aDNA) research, by providing complete genomic sequences of ancient individuals and extinct species. However, the ... [more ▼]

BACKGROUND: Next-Generation Sequencing has revolutionized our approach to ancient DNA (aDNA) research, by providing complete genomic sequences of ancient individuals and extinct species. However, the recovery of genetic material from long-dead organisms is still complicated by a number of issues, including post-mortem DNA damage and high levels of environmental contamination. Together with error profiles specific to the type of sequencing platforms used, these specificities could limit our ability to map sequencing reads against modern reference genomes and therefore limit our ability to identify endogenous ancient reads, reducing the efficiency of shotgun sequencing aDNA. RESULTS: In this study, we compare different computational methods for improving the accuracy and sensitivity of aDNA sequence identification, based on shotgun sequencing reads recovered from Pleistocene horse extracts using Illumina GAIIx and Helicos Heliscope platforms. We show that the performance of the Burrows Wheeler Aligner (BWA), that has been developed for mapping of undamaged sequencing reads using platforms with low rates of indel-types of sequencing errors, can be employed at acceptable run-times by modifying default parameters in a platform-specific manner. We also examine if trimming likely damaged positions at read ends can increase the recovery of genuine aDNA fragments and if accurate identification of human contamination can be achieved using a strategy previously suggested based on best hit filtering. We show that combining our different mapping and filtering approaches can increase the number of high-quality endogenous hits recovered by up to 33%. CONCLUSIONS: We have shown that Illumina and Helicos sequences recovered from aDNA extracts could not be aligned to modern reference genomes with the same efficiency unless mapping parameters are optimized for the specific types of errors generated by these platforms and by post-mortem DNA damage. Our findings have important implications for future aDNA research, as we define mapping guidelines that improve our ability to identify genuine aDNA sequences, which in turn could improve the genotyping accuracy of ancient specimens. Our framework provides a significant improvement to the standard procedures used for characterizing ancient genomes, which is challenged by contamination and often low amounts of DNA material. [less ▲]

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See detailIntercultural Learning
Hu, Adelheid UL

in Chapelle, Carol A. (Ed.) The Encyclopedia of Applied Linguistics (2012)

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See detailCompte rendu de l'ouvrage \textquotedblRelire Madeleine Bourdouxhe. Regards croisés sur son œuvre littéraire\textquotedbl
Goin, Emilie UL

in Textyles : Revue des Lettres Belges de Langue Française (2012), 42

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See detail‘Effectivité’ ‘efficacité’, ‘efficience’ et ‘qualité’ d’une norme/du droit. Analyse des mots et des concepts
Heuschling, Luc UL

in Fatin-Rouge Stéfanini, Marthe; Gay, Laurence; Vidal-Naquet, Ariane (Eds.) L’efficacité de la norme juridique. Nouveau vecteur de légitimité ? (2012)

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See detailFluctuations and response from a Hatano and Sasa approach
Verley, Gatien UL; Lacoste, David

in Physica Scripta (2012), 86(5), 058505

In this commentary paper, we present some of the main ideas on deriving a modified fluctuation-dissipation theorem off equilibrium, which in the end can all be related to an approach based on a ... [more ▼]

In this commentary paper, we present some of the main ideas on deriving a modified fluctuation-dissipation theorem off equilibrium, which in the end can all be related to an approach based on a generalized Hatano-Sasa relation. This generalized Hatano?Sasa relation also contains an interesting inequality, which can be viewed as a generalization of the second law of thermodynamics to transitions between non-equilibrium states. [less ▲]

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See detailPervasive Gaming as a Potential Solution to Traffic Congestion: New Challenges Regarding Ethics, Privacy and Trust
Koenig, Vincent UL; Boehm, Franziska UL; McCall, Roderick UL

in Entertainment Computing - ICEC 2012 (2012)

The following paper presents a review of the ethical, privacy and trust aspects relating to pervasive gaming in particular within the domain of traffic congestion. The paper deals explicitly with the ... [more ▼]

The following paper presents a review of the ethical, privacy and trust aspects relating to pervasive gaming in particular within the domain of traffic congestion. The paper deals explicitly with the challenges involved that fall between the gaps standard ethical practice and scientific research when studies comprise of those in the lab (where collection and use is heavily controlled) and those which take place in the wild where there is the requirement to share data possibly with external parties. Also where the nature of such work is at the borders of the concept of traditional study and a commercial running prototype. [less ▲]

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See detailPool vs. island based evolutionary algorithms: an initial exploration
Merelo, Juan Julian; Mora, Antonio M.; Fernandes, Carlos et al

in 2012 Seventh International Conference on P2P, Parallel, Grid, Cloud and Internet Computing (2012)

This paper explores the scalability and performance of pool and island based evolutionary algorithms, both of them using as a mean of interaction an object store; we call this family of algorithms SofEA ... [more ▼]

This paper explores the scalability and performance of pool and island based evolutionary algorithms, both of them using as a mean of interaction an object store; we call this family of algorithms SofEA. This object store allows the different clients to interact asynchronously; the point of the creation of this framework is to build a system for spontaneous and voluntary distributed evolutionary computation. The fact that each client is autonomous leads to a complex behavior that will be examined in the work, so that the design can be validated, rules of thumb can be extracted, and the limits of scalability can be found. In this paper we advance the design of an asynchronous, fault-tolerant and scalable distributed evolutionary algorithm based on the object store CouchDB. We test experimentally the different options and show the trade-offs that pool and island-based solutions offer. [less ▲]

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See detailSahara, terre féconde (1933) A Missionary Film Directed by White Father Félix Dufays
Lesch, Paul UL

in Kmec, Sonja; Thill, Viviane (Eds.) Tourists and Nomads. Amateur Images of Migration (2012)

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See detailBesetzte Vergangenheiten. Erinnerungskulturen des Zweiten Weltkrieges in Luxemburg – eine historiographische Baustelle
Majerus, Benoît UL

in Hemecht : Zeitschrift für Luxemburger Geschichte = Revue d'Histoire Luxembourgeoise (2012)

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See detailEine Kurzskala zur Messung von Impulsivität nach dem UPPS-Ansatz: Die Skala Impulsives-Verhalten-8 (I-8)
Kovaleva, A.; Beierlein, C.; Kemper, Christoph UL et al

Report (2012)

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See detailKurzskalen zur Messung der Ungerechtigkeitssensibilität: Die Ungerechtigkeitssensibiliät-Skalen-8 (USS-8)
Beierlein, C.; Baumert, A.; Schmitt, M. et al

Report (2012)

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See detailKurzskala zur Messung des zwischenmenschlichen Vertrauens: Die Kurzskala Interpersonales Vertrauen (KUSIV3)
Beierlein, C.; Kemper, Christoph UL; Kovaleva, A. et al

Report (2012)

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See detailEine kurze Skala zur Messung der fünf Dimensionen der Persönlichkeit: Big-Five-Inventory-10 (BFI-10)
Rammstedt, B.; Kemper, Christoph UL; Klein, M. C. et al

Report (2012)

Detailed reference viewed: 384 (0 UL)