References of "2012"
     in
Bookmark and Share    
Peer Reviewed
See detailDie Schule und die Religion der modernen Pädagogik
Tröhler, Daniel UL

in Domsgen; Schluss, Henning; Spenn, Matthias (Eds.) Was gehen uns ‘die anderen’ an? Schule und Religion in der Säkularität (2012)

Detailed reference viewed: 77 (1 UL)
See detailModeling default correlation in a US retail loan portfolio
Pisa, Magdalena UL

Presentation (2012)

Detailed reference viewed: 19 (6 UL)
Full Text
Peer Reviewed
See detailModel-based Product and Process Integration for Enhanced Collaboration during Mechatronic Design Processes
Seemueller, H.; Voos, Holger UL

in 2nd Workshop on Process-based Approaches for Model-Driven Engineering PMDE, Copenhagen 2-5 July 2012 (2012)

The collaborative design of mechatronic systems is still a challenging task as di erent engineering disciplines have to be considered and coordinated during the design process. Here, an independent and ... [more ▼]

The collaborative design of mechatronic systems is still a challenging task as di erent engineering disciplines have to be considered and coordinated during the design process. Here, an independent and isolated view on discipline-speci c tools, model data and activities is not appropriate. So, the integration of these aspects for improved collaboration is still a remaining task in industry and research. Former research have already developed rst solutions each directing into the integration of distinct aspects among the involved disciplines. This paper claims that a comprehensive view on the di erent aspects can bring signi cant bene ts for the design of mechatronic systems. In detail, it presents an approach which combines interdisciplinary system modeling with design activity management by describing and integrating these aspects on metalevel. This integration leads automatically to enhanced possibilities for design activity coordination and monitoring. [less ▲]

Detailed reference viewed: 69 (2 UL)
Full Text
See detailEine Kurzskala zur Messung von Optimismus-Pessimismus: Die Skala Optimismus-Pessimismus-2 (SOP2)
Kemper, Christoph UL; Beierlein, C.; Kovaleva, A. et al

Report (2012)

Detailed reference viewed: 191 (0 UL)
Full Text
Peer Reviewed
See detailIsotope pattern deconvolution for peptide mass spectrometry by non-negative least squares/least absolute deviation template matching.
Slawski, Martin; Hussong, René UL; Tholey, Andreas et al

in BMC Bioinformatics (2012), 13(291),

Background The robust identification of isotope patterns originating from peptides being analyzed through mass spectrometry (MS) is often significantly hampered by noise artifacts and the interference of ... [more ▼]

Background The robust identification of isotope patterns originating from peptides being analyzed through mass spectrometry (MS) is often significantly hampered by noise artifacts and the interference of overlapping patterns arising e.g. from post-translational modifications. As the classification of the recorded data points into either ‘noise’ or ‘signal’ lies at the very root of essentially every proteomic application, the quality of the automated processing of mass spectra can significantly influence the way the data might be interpreted within a given biological context. Results We propose non-negative least squares/non-negative least absolute deviation regression to fit a raw spectrum by templates imitating isotope patterns. In a carefully designed validation scheme, we show that the method exhibits excellent performance in pattern picking. It is demonstrated that the method is able to disentangle complicated overlaps of patterns. Conclusions We find that regularization is not necessary to prevent overfitting and that thresholding is an effective and user-friendly way to perform feature selection. The proposed method avoids problems inherent in regularization-based approaches, comes with a set of well-interpretable parameters whose default configuration is shown to generalize well without the need for fine-tuning, and is applicable to spectra of different platforms. The R package IPPD implements the method and is available from the Bioconductor platform (http://bioconductor.fhcrc.org/help/bioc-views/devel/bioc/html/IPPD.html) [less ▲]

Detailed reference viewed: 101 (0 UL)
Full Text
Peer Reviewed
See detail‘Doing science’ through discourse-in-interaction: Young children’s science investigations at the early childhood level.
Siry, Christina UL; Ziegler, Gudrun UL; Max, Charles UL

in Science Education (2012), 96(2), 311-326

This research investigates the interconnectedness of scientific inquiring at the early childhood level, as we explore the discourse-in-interaction processes occurring within small inquiry groups of 5- and ... [more ▼]

This research investigates the interconnectedness of scientific inquiring at the early childhood level, as we explore the discourse-in-interaction processes occurring within small inquiry groups of 5- and 6-year-old children. The rationale behind this research is to explore the nature of science-related discourse, and to that end, this work focuses on student-to-student interactions as they collaboratively investigate water. As we document the nature of children's ways of explaining, imagining, and representing the properties of water, we demonstrate the constructions of understandings as displayed and emergent from these interactions. The study has generated outcomes about the discursive ways of young children's enacting of knowledge about science, as the analysis reveals that by positioning scientific inquiry as a fluid process children were able to enact science collaboratively and through multimodal means. As such, the study reveals a wide range of indicators to children's understandings about water and to the processes in which students worked together to construct science within discourse-in-interaction [less ▲]

Detailed reference viewed: 216 (5 UL)
Full Text
See detailAn analysis of the utilization of video-based media in science teacher education
Martin, Sonya, N.; Siry, Christina UL

in Fraser, B; Tobin, K; Campbell, C (Eds.) International handbook of science teaching and learning (2012)

In this chapter, we examine trends involving video usage in science teacher education and science education research. We tracing some developments in video technologies and explore examples of the ways in ... [more ▼]

In this chapter, we examine trends involving video usage in science teacher education and science education research. We tracing some developments in video technologies and explore examples of the ways in which video/multimedia have been utilized in the education of science teachers. We conclude the review by summarizing our findings, and then offer implications for future research on the utilization of video and multimedia technologies in the preparation and professional development of science teachers. Specifically we raise questions and considerations for future research as it relates to science teacher education and research in science education. [less ▲]

Detailed reference viewed: 114 (3 UL)
Full Text
Peer Reviewed
See detailRelative Gravity Measurement Campaign during the 8th International Comparison of Absolute Gravimeters (2009)
Jiang, Z.; Pálinkáš, V.; Francis, Olivier UL et al

in Metrologia (2012), 49(1), 95

The 8th International Comparison of Absolute Gravimeters (ICAG-2009) and the associated Relative Gravity Campaign (RGC2009) took place at the Bureau International des Poids et Mesures (BIPM) between July ... [more ▼]

The 8th International Comparison of Absolute Gravimeters (ICAG-2009) and the associated Relative Gravity Campaign (RGC2009) took place at the Bureau International des Poids et Mesures (BIPM) between July and October 2009. Altogether 24 institutes with 22 absolute gravimeters and 9 relative gravimeters participated in the ICAG/RGC campaign. Accurate absolute and relative gravity measurements as well as precision levelling measurements were performed on the micro-gravity 3D-grid at the BIPM. The 2009 comparison was the first to be organized as a Comité International des Poids et Mesures (CIPM) metrological Key Comparison under the CIPM MRA (Mutual Recognition Arrangement), which means that the result will be officially recognized by the governmental organizations responsible. As a consequence, the relative gravimeters employed were carefully selected and the measurement schedules were rigorously enforced compared with earlier campaigns. Thus the quality of the RGC2009 and the determination of the BIPM local gravity network were improved. After 30 years and eight successive ICAGs, the BIPM has decided to transfer its role to the national metrological institutes, although the CIPM will continue to organize the key comparison as ICAGs. The background to the RGC2009, and the organization, data processing and final results of the gravity and vertical gravity gradients, are presented in this paper. This report is more detailed than previous final reports of the RGCs. [less ▲]

Detailed reference viewed: 140 (6 UL)
Full Text
Peer Reviewed
See detailUne «écologie du plurilinguisme» : les classes multiculturelles au Luxembourg
Ehrhart, Sabine UL

in Trépos, Jean-Yves (Ed.) Les dispositifs modestes du souci. Expérimentation, réflexivité et modélisation dans l'intervention sociale (2012)

Detailed reference viewed: 120 (11 UL)
Peer Reviewed
See detailConclusions. Histoire industrielle - Bilan & Perspectives
Caregari, Laure UL; Leboutte, René UL; Sauer, Arnaud UL et al

in Hémecht. Revue d'Histoire luxembourgeoise transnationale, locale, interdisciplinaire (2012)

Detailed reference viewed: 95 (8 UL)
Full Text
Peer Reviewed
See detailMerging the Quality Assessment of Processes and Products in Automotive Domain
Adedjouma, Morayo UL; Dubois, Hubert; Terrier, François et al

in Proceedings of the 13th International Conference on Product-Focused Software Process Improvement (PROFES 2012) (2012)

Detailed reference viewed: 98 (0 UL)
Full Text
Peer Reviewed
See detailImproving the performance of true single molecule sequencing for ancient DNA.
Ginolhac, Aurélien UL; Vilstrup, Julia; Stenderup, Jesper et al

in BMC genomics (2012), 13

BACKGROUND: Second-generation sequencing technologies have revolutionized our ability to recover genetic information from the past, allowing the characterization of the first complete genomes from past ... [more ▼]

BACKGROUND: Second-generation sequencing technologies have revolutionized our ability to recover genetic information from the past, allowing the characterization of the first complete genomes from past individuals and extinct species. Recently, third generation Helicos sequencing platforms, which perform true Single-Molecule DNA Sequencing (tSMS), have shown great potential for sequencing DNA molecules from Pleistocene fossils. Here, we aim at improving even further the performance of tSMS for ancient DNA by testing two novel tSMS template preparation methods for Pleistocene bone fossils, namely oligonucleotide spiking and treatment with DNA phosphatase. RESULTS: We found that a significantly larger fraction of the horse genome could be covered following oligonucleotide spiking however not reproducibly and at the cost of extra post-sequencing filtering procedures and skewed %GC content. In contrast, we showed that treating ancient DNA extracts with DNA phosphatase improved the amount of endogenous sequence information recovered per sequencing channel by up to 3.3-fold, while still providing molecular signatures of endogenous ancient DNA damage, including cytosine deamination and fragmentation by depurination. Additionally, we confirmed the existence of molecular preservation niches in large bone crystals from which DNA could be preferentially extracted. CONCLUSIONS: We propose DNA phosphatase treatment as a mechanism to increase sequence coverage of ancient genomes when using Helicos tSMS as a sequencing platform. Together with mild denaturation temperatures that favor access to endogenous ancient templates over modern DNA contaminants, this simple preparation procedure can improve overall Helicos tSMS performance when damaged DNA templates are targeted. [less ▲]

Detailed reference viewed: 79 (1 UL)
Full Text
See detailBypassing the Combinatorial Explosion: Using Similarity to Generate and Prioritize T-wise Test Suites for Large Software Product Lines
Henard, Christopher UL; Papadakis, Mike UL; Perrouin, Gilles UL et al

Report (2012)

Software Product Lines (SPLs) are families of products whose commonalities and variability can be captured by Feature Models (FMs). T-wise testing aims at finding errors triggered by all interactions ... [more ▼]

Software Product Lines (SPLs) are families of products whose commonalities and variability can be captured by Feature Models (FMs). T-wise testing aims at finding errors triggered by all interactions amongst t features, thus reducing drastically the number of products to test. T-wise testing approaches for SPLs are limited to small values of t -- which miss faulty interactions -- or limited by the size of the FM. Furthermore, they neither prioritize the products to test nor provide means to finely control the generation process. This paper offers (a) a search-based approach capable of generating products for large SPLs, forming a scalable and flexible alternative to current techniques and (b) prioritization algorithms for any set of products. Experiments conducted on 124 FMs (including large FMs such as the Linux kernel) demonstrate the feasibility and the practicality of our approach. [less ▲]

Detailed reference viewed: 148 (6 UL)
Full Text
See detailA Formal Semantics of Kermeta
Amrani, Moussa UL

Report (2012)

Detailed reference viewed: 102 (0 UL)
See detailNe pas réinventer la roue! L'éducation multilingue au Pays Basque et en Afrique du Sud (et les leçons qu'on peut en tirer)
Weber, Jean-Jacques UL

in Forum für Politik, Gesellschaft und Kultur in Luxemburg (2012), 324

Detailed reference viewed: 108 (6 UL)
Full Text
Peer Reviewed
See detailLarge-scale replication and heterogeneity in Parkinson disease genetic loci.
Sharma, Manu; Ioannidis, John P. A.; Aasly, Jan O. et al

in Neurology (2012), 79(7), 659-67

OBJECTIVE: Eleven genetic loci have reached genome-wide significance in a recent meta-analysis of genome-wide association studies in Parkinson disease (PD) based on populations of Caucasian descent. The ... [more ▼]

OBJECTIVE: Eleven genetic loci have reached genome-wide significance in a recent meta-analysis of genome-wide association studies in Parkinson disease (PD) based on populations of Caucasian descent. The extent to which these genetic effects are consistent across different populations is unknown. METHODS: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium were invited to participate in the study. A total of 11 SNPs were genotyped in 8,750 cases and 8,955 controls. Fixed as well as random effects models were used to provide the summary risk estimates for these variants. We evaluated between-study heterogeneity and heterogeneity between populations of different ancestry. RESULTS: In the overall analysis, single nucleotide polymorphisms (SNPs) in 9 loci showed significant associations with protective per-allele odds ratios of 0.78-0.87 (LAMP3, BST1, and MAPT) and susceptibility per-allele odds ratios of 1.14-1.43 (STK39, GAK, SNCA, LRRK2, SYT11, and HIP1R). For 5 of the 9 replicated SNPs there was nominally significant between-site heterogeneity in the effect sizes (I(2) estimates ranged from 39% to 48%). Subgroup analysis by ethnicity showed significantly stronger effects for the BST1 (rs11724635) in Asian vs Caucasian populations and similar effects for SNCA, LRRK2, LAMP3, HIP1R, and STK39 in Asian and Caucasian populations, while MAPT rs2942168 and SYT11 rs34372695 were monomorphic in the Asian population, highlighting the role of population-specific heterogeneity in PD. CONCLUSION: Our study allows insight to understand the distribution of newly identified genetic factors contributing to PD and shows that large-scale evaluation in diverse populations is important to understand the role of population-specific heterogeneity. [less ▲]

Detailed reference viewed: 171 (0 UL)
Full Text
Peer Reviewed
See detailMagnetic neutron scattering on nanocomposites: Decrypting cross-section images using micromagnetic simulations
Erokhin, Sergey; Berkov, Dmitry; Gorn, Nataliya et al

in Physical Review. B, Condensed Matter and Materials Physics (2012), 85(134418), 1-5

Detailed reference viewed: 112 (2 UL)
See detailTotemic Immimanence
Van Der Walt, Johan Willem Gous UL

in Motha, Stewart (Ed.) Reading Modern Law (2012)

Detailed reference viewed: 150 (4 UL)
Full Text
Peer Reviewed
See detailMonitoring and Predicting Hardware Failures in HPC Clusters with FTB-IPMI
Rajachandrasekar, Raghunath; Besseron, Xavier UL; Panda, Dhabaleswar K.

in Proceedings of the 2012 IEEE 26th International Parallel and Distributed Processing Symposium Workshops & PhD Forum (2012)

Fault-detection and prediction in HPC clusters and Cloud-computing systems are increasingly challenging issues. Several system middleware such as job schedulers and MPI implementations provide support for ... [more ▼]

Fault-detection and prediction in HPC clusters and Cloud-computing systems are increasingly challenging issues. Several system middleware such as job schedulers and MPI implementations provide support for both reactive and proactive mechanisms to tolerate faults. These techniques rely on external components such as system logs and infrastructure monitors to provide information about hardware/software failure either through detection, or as a prediction. However, these middleware work in isolation, without disseminating the knowledge of faults encountered. In this context, we propose a light-weight multi-threaded service, namely FTB-IPMI, which provides distributed fault-monitoring using the Intelligent Platform Management Interface (IPMI) and coordinated propagation of fault information using the Fault-Tolerance Backplane (FTB). In essence, it serves as a middleman between system hardware and the software stack by translating raw hardware events to structured software events and delivering it to any interested component using a publish-subscribe framework. Fault-predictors and other decision-making engines that rely on distributed failure information can benefit from FTB-IPMI to facilitate proactive fault-tolerance mechanisms such as preemptive job migration. We have developed a fault-prediction engine within MVAPICH2, an RDMA-based MPI implementation, to demonstrate this capability. Failure predictions made by this engine are used to trigger migration of processes from failing nodes to healthy spare nodes, thereby providing resilience to the MPI application. Experimental evaluation clearly indicates that a single instance of FTB-IPMI can scale to several hundreds of nodes with a remarkably low resource-utilization footprint. A deployment of FTB-IPMI that services a cluster with 128 compute-nodes, sweeps the entire cluster and collects IPMI sensor information on CPU temperature, system voltages and fan speeds in about 0.75 seconds. The average CPU utilization of this service running on a single node is 0.35%. [less ▲]

Detailed reference viewed: 135 (9 UL)
Full Text
Peer Reviewed
See detailValidating a Peer-to-Peer Evolutionary Algorithm
Jimenez Laredo, Juan Luis UL; Bouvry, Pascal UL; Mostaghim, Sanaz et al

in European Conference on the Applications of Evolutionary Computation (2012)

Detailed reference viewed: 173 (5 UL)