PLAU inferred from a correlation network is critical for suppressor function of regulatory T cells

in Molecular Systems Biology (2012)

Les littératures au Luxembourg: Tour d'horizon d'une médiation difficile

in Colas-Blaise, Marion; Tore, Gian-Maria (Eds.) Médias et médiations culturelles au Luxembourg (2012)

Caipirini: using gene sets to rank literature

in BioData Mining (2012), 5(1),

Background: Keeping up-to-date with bioscience literature is becoming increasingly challenging. Several recent methods help meet this challenge by allowing literature search to be launched based on lists ... [more ▼]

Background: Keeping up-to-date with bioscience literature is becoming increasingly challenging. Several recent methods help meet this challenge by allowing literature search to be launched based on lists of abstracts that the user judges to be ‘interesting’. Some methods go further by allowing the user to provide a second input set of ‘uninteresting’ abstracts; these two input sets are then used to search and rank literature by relevance. In this work we present the service ‘Caipirini’ (http:// caipirini.org) that also allows two input sets, but takes the novel approach of allowing ranking of literature based on one or more sets of genes. Results: To evaluate the usefulness of Caipirini, we used two test cases, one related to the human cell cycle, and a second related to disease defense mechanisms in Arabidopsis thaliana. In both cases, the new method achieved high precision in finding literature related to the biological mechanisms underlying the input data sets. Conclusions: To our knowledge Caipirini is the first service enabling literature search directly based on biological relevance to gene sets; thus, Caipirini gives the research community a new way to unlock hidden knowledge from gene sets derived via high-throughput experiments. [less ▲]

PathVar: analysis of gene and protein expression variance in cellular pathways using microarray data

in Bioinformatics (2012)

Finding significant differences between the expression levels of genes or proteins across diverse biological conditions is one of the primary goals in the analysis of functional genomics data. However ... [more ▼]

Finding significant differences between the expression levels of genes or proteins across diverse biological conditions is one of the primary goals in the analysis of functional genomics data. However, existing methods for identifying differentially expressed genes or sets of genes by comparing measures of the average expression across predefined sample groups do not detect differential variance in the expression levels across genes in cellular pathways. Since corresponding pathway deregulations occur frequently in microarray gene or protein expression data, we present a new dedicated web application, PathVar, to analyze these data sources. The software ranks pathway-representing gene/protein sets in terms of the differences of the variance in the within-pathway expression levels across different biological conditions. Apart from identifying new pathway deregulation patterns, the tool exploits these patterns by combining different machine learning methods to find clusters of similar samples and build sample classification models. [less ▲]

Auf den Spuren der Akteure: Ein organisationaler Veränderungsprozess aus Perspektive der Akteur-Netzwerk Theorie

Bachelor/master dissertation (2012)

Defending the Doomed: Implicit Strategies concerning Protection of First Person Shooter Games

in Cyberpsychology, Behavior, and Social Networking (2012), 15

Abstract Censorship of violent digital games, especially first-person shooter (FPS) games, is broadly discussed between generations. While older people are concerned about possible negative influences of ... [more ▼]

Abstract Censorship of violent digital games, especially first-person shooter (FPS) games, is broadly discussed between generations. While older people are concerned about possible negative influences of these games, not only players but also nonplayers of the younger net-generation seem to deny any association with real aggressive behavior. Our study aimed at investigating defense mechanisms players and nonplayers use to defend FPS and peers with playing habits. By using a lexical decision task, we found that aggressive concepts are activated by priming the content of FPS but suppressed afterward. Only if participants were instructed to actively suppress aggressive concepts after priming, thought suppression was no longer necessary. Young people still do have negative associations with violent video games. These associations are neglected by implicitly applying defense strategies—independent of own playing habits—to protect this specific hobby, which is common for the netgeneration. [less ▲]

Crystallization process in supersaturated in colloidal hard-sphere suspensions

Poster (2012)

An Experiment on Merging Quality Assessment in Automotive Domain

in 12th International Conference, SPICE 2012, Palma, Spain, May 29-31, 2012. Proceedings (2012)

Philosophy, exposure and children: How to resist the instrumentalisation of philosophy in education

in Vansieleghem, N.; Kennedy, D. (Eds.) Philosophy for children in transition: Problems and prospects. (2012)

Moving Towards IPV6

in Technical Sciences (2012)

This document describes the possibilities for Internet Protocol communications in crisis situations. Its main goal is to show IPv4 and IPv6 solutions developed during the lifetime of the SECRICOM project ... [more ▼]

This document describes the possibilities for Internet Protocol communications in crisis situations. Its main goal is to show IPv4 and IPv6 solutions developed during the lifetime of the SECRICOM project. Communications technologies in current use are showing their limitations. Whether reacting to a small incident or a great catastrophe, first responders increasingly need to share information such as video, images or other data. Society’s evolving expectations concerning safety can be compared with the development of Internet protocols. We examine IP-based communication for crisis management, and show that it is ready to bind together currently fragmented technologies such as TETRA and analogue radios, providing a new dimension of interoperability, including cross-border communication. [less ▲]