![]() ; Schlenker, Jean-Marc ![]() in Duke Mathematical Journal (2009), 150(2), 331--356 Detailed reference viewed: 110 (1 UL)![]() Sanctuary, Roland ![]() ![]() ![]() in Chemical Physics Letters (2009), 476(1-3), 11-14 Scanning Brillouin microscopy visualizes the temporal evolution of a heterogeneous hypersonic profile during chemical reactions and transport processes around a planar phase boundary between an epoxy ... [more ▼] Scanning Brillouin microscopy visualizes the temporal evolution of a heterogeneous hypersonic profile during chemical reactions and transport processes around a planar phase boundary between an epoxy resin and hardener. The hypersonic investigations are interpreted in terms of structural formation and annihilation in the layered sample and are compared to results obtained for a well mixed bulk sample of the same composition of reactants. Chaotic transport channels are made responsible for the creation of local glassy heterogeneities not observable in the bulk material on a macroscopic level. [less ▲] Detailed reference viewed: 169 (0 UL)![]() Chatzinotas, Symeon ![]() in IEEE Transactions on Wireless Communications (2009), 8(7), 3704-3715 Detailed reference viewed: 124 (10 UL)![]() ; ; Baumann, Michèle ![]() in International Institute, of Sociology (Ed.) 39th World Congress of the International Institute of Sociology (2009) This study assessed associations between demanding workplace conditions and substance use in France, taking account of gender. A total of 13,241 workers were randomly selected and interviewed by telephone ... [more ▼] This study assessed associations between demanding workplace conditions and substance use in France, taking account of gender. A total of 13,241 workers were randomly selected and interviewed by telephone to obtain information about: alcohol use, tobacco use, cannabis use, socio-demographic characteristics, occupation, type of work contract, and working conditions (physical and mental demands, time pressure, lack of rest, satisfaction with conditions, opportunity to learn new things). Data were analyzed using multivariate logistic models. Alcohol abuse was reported by 20% of men and 11% of women; 32% and 24%, respectively, used tobacco every day; and 9% and 3% had used cannabis in the previous 12 months (p<0.001). Among men, tobacco use related to physical and mental demands, dissatisfaction with work and not learning new things (increased risk IR 22-31%). Among women, it related to physical demand, time pressure, lack of rest and not learning new things (IR 15-43%). Alcohol abuse related to dissatisfaction with work among men (IR 22%). Cannabis use related to dissatisfaction with work in men (IR 93%). Having a short-term contract related to all three substances uses among men (IR 25-57%) and to alcohol abuse and tobacco use among women (IR 21-35%). Being freelance related to use of tobacco and cannabis use among men (IR 50-89%). In conclusion, alcohol, tobacco and cannabis use were related to demanding occupational conditions, but in different ways among males and females. These findings suggest that improving workplace conditions and limiting short-term and freelance employment may help prevent substance use and related diseases. [less ▲] Detailed reference viewed: 79 (0 UL)![]() Biesta, Gert ![]() Book published by Unge Pædagoger (2009) Detailed reference viewed: 88 (0 UL)![]() ; ; et al in Solid-State Electronics (2009), 53(10), 1144-1148 Detailed reference viewed: 127 (1 UL)![]() Michels, Tom ![]() ![]() ![]() Scientific Conference (2009) Detailed reference viewed: 60 (0 UL)![]() Nourdin, Ivan ![]() ![]() in Annals of Probability (2009), 37(6), 2231--2261 Detailed reference viewed: 203 (1 UL)![]() ; ; et al in BMC Systems Biology (2009), 3 BACKGROUND: Biological effects of nuclear factor-kappaB (NF kappaB) can differ tremendously depending on the cellular context. For example, NF kappaB induced by interleukin-1 (IL-1) is converted from an ... [more ▼] BACKGROUND: Biological effects of nuclear factor-kappaB (NF kappaB) can differ tremendously depending on the cellular context. For example, NF kappaB induced by interleukin-1 (IL-1) is converted from an inhibitor of death receptor induced apoptosis into a promoter of ultraviolet-B radiation (UVB)-induced apoptosis. This conversion requires prolonged NF kappaB activation and is facilitated by IL-1 + UVB-induced abrogation of the negative feedback loop for NF kappaB, involving a lack of inhibitor of kappaB (I kappaB alpha) protein reappearance. Permanent activation of the upstream kinase IKK beta results from UVB-induced inhibition of the catalytic subunit of Ser-Thr phosphatase PP2A (PP2Ac), leading to immediate phosphorylation and degradation of newly synthesized I kappaB alpha. RESULTS: To investigate the mechanism underlying the general PP2A-mediated tuning of IKK beta phosphorylation upon IL-1 stimulation, we have developed a strictly reduced mathematical model based on ordinary differential equations which includes the essential processes concerning the IL-1 receptor, IKK beta and PP2A. Combining experimental and modelling approaches we demonstrate that constitutively active, but not post-stimulation activated PP2A, tunes out IKK beta phosphorylation thus allowing for I kappaB alpha resynthesis in response to IL-1. Identifiability analysis and determination of confidence intervals reveal that the model allows reliable predictions regarding the dynamics of PP2A deactivation and IKK beta phosphorylation. Additionally, scenario analysis is used to scrutinize several hypotheses regarding the mode of UVB-induced PP2Ac inhibition. The model suggests that down regulation of PP2Ac activity, which results in prevention of I kappaB alpha reappearance, is not a direct UVB action but requires instrumentality. CONCLUSION: The model developed here can be used as a reliable building block of larger NF kappa B models and offers comprehensive simplification potential for future modeling of NF kappa B signaling. It gives more insight into the newly discovered mechanisms for IKK deactivation and allows for substantiated predictions and investigation of different hypotheses. The evidence of constitutive activity of PP2Ac at the IKK complex provides new insights into the feedback regulation of NF kappa B, which is crucial for the development of new anti-cancer strategies. [less ▲] Detailed reference viewed: 78 (0 UL)![]() Steffgen, Georges ![]() in Perspektive Mediation (2009), 6 Im Kontext eines Mediationsprozesses sind häufig emotionale Reaktionen der Beteiligten festzustellen. Insbesondere Ärgerreaktionen können auftreten und sich sowohl destruktiv als auch konstruktiv auf die ... [more ▼] Im Kontext eines Mediationsprozesses sind häufig emotionale Reaktionen der Beteiligten festzustellen. Insbesondere Ärgerreaktionen können auftreten und sich sowohl destruktiv als auch konstruktiv auf die Konfliktbearbeitung auswirken. Aufbauend auf einer Analyse der Funktionalität und Internationalität des Ärgers kann eine selbst- oder fremdgerichtete Ärgerregulation indiziert sein. Konkrete Möglichkeiten werden hierzu aufgezeigt. [less ▲] Detailed reference viewed: 79 (0 UL)![]() Schulz, André ![]() in Frontiers in Behavioral Neuroscience (2009) Detailed reference viewed: 62 (1 UL)![]() Hoffmann, Martine ![]() ![]() in Final Conference of the CARERS Project, Liaison Office Brussels. Brussels ,Belgium (2009) Detailed reference viewed: 44 (1 UL)![]() ![]() Pauly, Michel ![]() in Der Luxemburg Atlas / Atlas du Luxembourg: Vielfalt und Wandel Luxemburgs im Kartenbild (2009) Detailed reference viewed: 108 (6 UL)![]() Majerus, Benoît ![]() in Jeanneney, Jean-Noël (Ed.) 27 leçons d'histoire (2009) Detailed reference viewed: 120 (6 UL)![]() Tröhler, Daniel ![]() Book published by Pestalozzianum (2009) Achtbändige Studienausgabe der Werke Johann Heinrich Pestalozzis. In den hier versammelten Schriften zur Französischen Revolution setzt sich Pestalozzi mit den sozialen und wirtschaftlichen Ursachen und ... [more ▼] Achtbändige Studienausgabe der Werke Johann Heinrich Pestalozzis. In den hier versammelten Schriften zur Französischen Revolution setzt sich Pestalozzi mit den sozialen und wirtschaftlichen Ursachen und Folgen der Französischen Revolution auseinander. Diese Analysen erlauben es ihm, Stellung zu den politischen Unruhen nehmen, die im Gefolge der Französischen Revolution auch auf die Schweiz übergriffen (Stäfner Unruhen 1794/95). Trotz seiner grundsätzlichen Sympathie für die Anliegen der minder berechtigten Landbevölkerung weist er eine Neuorientierung der Gesellschaft zurück, die nur das wirtschaftliche Eigeninteresse der Bürger ins Zentrum rückt und das Gemeinwohl vernachlässigt. [less ▲] Detailed reference viewed: 66 (0 UL)![]() Pauly, Michel ![]() in Margue, Michel; Pauly, Michel; Schmid, Wolfgang (Eds.) Der Weg zur Kaiserkrone. Der Romzug Heinrichs VII. in der Darstellung Erzbischof Balduins von Trier (2009) Detailed reference viewed: 57 (0 UL)![]() ; ; Schulz, André ![]() in Frontiers in Behavioral Neuroscience (2009) Detailed reference viewed: 110 (0 UL)![]() ; Tröhler, Daniel ![]() Book published by Lep (2009) Detailed reference viewed: 64 (0 UL)![]() Kmec, Sonja ![]() ![]() in Majerus, Benoît; Kmec, Sonja; Margue, Michel (Eds.) et al Dépasser le cadre national des 'lieux de mémoire'. Innovations méthodologiques, approches comparatives, lectures transnationales (2009) Detailed reference viewed: 162 (7 UL)![]() ; ; et al in PLoS Computational Biology (2009), 5(12), 1000595 Apoptosis is regulated by several signaling pathways which are extensively linked by crosstalks. Boolean or logical modeling has become a promising approach to capture the qualitative behavior of such ... [more ▼] Apoptosis is regulated by several signaling pathways which are extensively linked by crosstalks. Boolean or logical modeling has become a promising approach to capture the qualitative behavior of such complex networks. Here we built a large-scale literature-based Boolean model of the central intrinsic and extrinsic apoptosis pathways as well as pathways connected with them. The model responds to several external stimuli such as Fas ligand, TNF-alpha, UV-B irradiation, interleukin-1beta and insulin. Timescales and multi-value node logic were used and turned out to be indispensable to reproduce the behavior of the apoptotic network. The coherence of the model was experimentally validated. Thereby an UV-B dose-effect is shown for the first time in mouse hepatocytes. Analysis of the model revealed a tight regulation emerging from high connectivity and spanning crosstalks and a particular importance of feedback loops. An unexpected feedback from Smac release to RIP could further increase complex II formation. The introduced Boolean model provides a comprehensive and coherent description of the apoptosis network behavior. It gives new insights into the complex interplay of pro- and antiapoptotic factors and can be easily expanded to other signaling pathways. [less ▲] Detailed reference viewed: 142 (7 UL) |
||