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See detailMitochondrial protein quality control by the proteasome involves ubiquitination and the protease Omi.
Radke, Susanne; Chander, Harish; Schafer, Patrick et al

in The Journal of biological chemistry (2008), 283(19), 12681-5

We report here that blocking the activity of the 26 S proteasome results in drastic changes in the morphology of the mitochondria and accumulation of intermembrane space (IMS) proteins. Using endonuclease ... [more ▼]

We report here that blocking the activity of the 26 S proteasome results in drastic changes in the morphology of the mitochondria and accumulation of intermembrane space (IMS) proteins. Using endonuclease G (endoG) as a model IMS protein, we found that accumulation of wild-type but to a greater extent mutant endoG leads to changes in the morphology of the mitochondria similar to those observed following proteasomal inhibition. Further, we show that wild-type but to a greater extent mutant endoG is a substrate for ubiquitination, suggesting the presence of a protein quality control. Conversely, we also report that wild-type but not mutant endoG is a substrate for the mitochondrial protease Omi but only upon inhibition of the proteasome. These findings suggest that although elimination of mutant IMS proteins is strictly dependent on ubiquitination, elimination of excess or spontaneously misfolded wild-type IMS proteins is monitored by ubiquitination and as a second checkpoint by Omi cleavage when the proteasome function is deficient. One implication of our finding is that in the context of attenuated proteasomal function, accumulation of IMS proteins would contribute to the collapse of the mitochondrial network such as that observed in neurodegenerative diseases. Another implication is that such collapse could be accelerated either by mutations in IMS proteins or by mutations in Omi itself. [less ▲]

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See detailA framework to understand Project Robustness
Gericke, Kilian UL; Schmidt-Kretschmer, Michael; Blessing, Lucienne UL

in Proceedings of the 10th International Design Conference - DESIGN 2008 (2008)

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See detailIntegration von formal Geringqualifizierten in den Arbeitsmarkt.
Dornmayr, Helmut; Lachmayr, Norbert; Rothmüller, Barbara UL

Report (2008)

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See detailTopic-based Transparent Replication of Digital Assets
Wehling, Ulf; Rothkugel, Steffen UL

in Ibrahim, Ismail Khalil (Ed.) Handbook of Research on Mobile Multimedia (2008)

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See detailThe Socialisation of Hierarchic Self-Interest?Value Socialization in the Family
Hadjar, Andreas UL; Baier, Dirk; Boehnke, Klaus

in Young : Nordic Journal of Youth Research (2008), 16(3), 279-301

The article reports research on family socialization of dominance values among adolescents. Dominance values were studied as expressed in Hierarchic Self-Interest (HSI), a value pattern that is typical ... [more ▼]

The article reports research on family socialization of dominance values among adolescents. Dominance values were studied as expressed in Hierarchic Self-Interest (HSI), a value pattern that is typical for highly competitive market-oriented societies and has negative behavioural consequences. In analyzing socialization, the study concentrates on authoritarian and achievement-focused parenting, as well as structural and ideological predictors thereof. The relevance of HSI for attitudes and behaviours is studied by considering xenophobia and delinquency as its consequences. Using panel data of 443 families (mothers, fathers, and adolescent offspring) from Berlin (Germany), a structural equation model is estimated. Results show that adolescent HSI can be traced back to social-structural variables and parenting modes, but also develops through intergenerational value transmission. It has assumed negative consequences. [less ▲]

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See detail« Mais vous tapez comme un pharmacien ! » : analogies en formation professionnelle initiale.
Filliettaz, Laurent; de Saint-Georges, Ingrid UL; Duc, Barbara

in Filliettaz, Laurent; Schubauer-Leoni, Maria-Luisa (Eds.) Processus interactionnels et situations éducatives (2008)

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See detailJede Kunstforschung war einmal zeitgenössisch
Dell, Paul UL

in Bourg, Viviane; Dell, Paul; Di Felice, Paul (Eds.) Arts visuels – Architecture / Jeunes chercheurs luxembourgeois en Arts Visuels et Architecture (2008)

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See detailAnalysis and synthesis of logics
Carnielli, Walter; Coniglio, Marcelo; Gabbay, Dov M. UL et al

Book published by Springer (2008)

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See detailMortalitätssalienz und Angstbewältigung im Kontext einer Krebserkrankung
Hoffmann, Martine UL

Book published by Pabst (2008)

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See detailTowards sustainable materials for solar energy conversion: Preparation and photoelectrochemical characterization of Cu2ZnSnS4
Scragg, Jonathan J.; Dale, Phillip UL; Peter, Laurence

in Electrochemistry Communications (2008), 10(4), 639-642

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See detail« Vos mains sont intelligentes ! » : Interactions en formation professionnelle initiale.
Filliettaz, Laurent; de Saint-Georges, Ingrid UL; Duc, Barbara

Book published by Université de Genève, Cahiers de la Section des Sciences de l’Education, 117. (2008)

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See detailA FRAMEWORK TO UNDERSTAND PROJECT ROBUSTNESS
Gericke, Kilian UL; Blessing, Lucienne UL

Poster (2008)

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See detailDas Subjekt des Diskurses
Geisenhanslüke, Achim; Schößler, Franziska; Mein, Georg UL

Book published by Synchron (2008)

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See detailVon "Disengagement" zu "Successful Ageing": Modellvorstellungen über das (gute) Altern
Ferring, Dieter UL

in Soziokulturelle Konstruktion des Alters Transdisziplinäre Perspektiven (2008)

Detailed reference viewed: 93 (5 UL)
See detailDas Subjekt der Trauer Über Autorschaft und Melancholie
Mein, Georg UL

in Geisenhanslüke, Achim; Schößler, Franziska; Mein, Georg (Eds.) Das Subjekt des Diskurses (2008)

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See detailBullying in Schulen Prädiktoren zivilcouragierten Verhaltens
Huberty, Yan; Steffgen, Georges UL

Book published by VDM Verlag Dr. Müller (2008)

Detailed reference viewed: 94 (2 UL)
See detailText ohne Noten? Für eine Texttheorie des Ornamentalen am Beispiel von Rabener und Jean Paul
Dembeck, Till UL

in Metz, Bernhard; Zubarik, Sabine (Eds.) Am Rande bemerkt. Anmerkungspraktiken in literarischen Texten (2008)

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See detailDas Unerhörte der Erinnerung des Unerhörten. Zur ästhetischen Produktivität der Memoria in der Nach-Wende-Novellistik
Heimböckel, Dieter UL

in Gilleir, Anke; De Winde, Arne (Eds.) Literatur im Krebsgang. Totenbeschwörung und Memoria in der deutschsprachigen Gegenwartsliteratur nach 1989 (2008)

Detailed reference viewed: 134 (1 UL)