The tradition of Community Music in Luxembourg

Scientific Conference (2007, July)

Visuo-spatial working memory (VSWM) capacity in mental strategies used with Kohs Block Design Test

Scientific Conference (2007, July)

Probabilistic Certification of Divide & Conquer Algorithms on Global Computing Platforms. Application to Fault-Tolerant Exact Matrix-Vector Product

in Proc. of the ACM Intl. Workshop on Parallel Symbolic Computation’07 (PASCO’07) (2007, July)

Quantum dynamics of single-photon detection

in Optics & Spectroscopy (2007), 103(1), 121-128

Dynamics of the elementary photoelectric conversion upon interaction of a single-photon mode with a bound electron in a one-dimensional rectangular potential well is considered. The spatial and temporal ... [more ▼]

Dynamics of the elementary photoelectric conversion upon interaction of a single-photon mode with a bound electron in a one-dimensional rectangular potential well is considered. The spatial and temporal dynamics of the wave packet corresponding to a free photoelectron is investigated. [less ▲]

Arabidopsis VTC2 encodes a GDP-L-galactose phosphorylase, the last unknown enzyme in the Smirnoff-Wheeler pathway to ascorbic acid in plants

in Journal of Biological Chemistry (2007), 282(26), 18879-85

The first committed step in the biosynthesis of L-ascorbate from D-glucose in plants requires conversion of GDP-L-galactose to L-galactose 1-phosphate by a previously unidentified enzyme. Here we show ... [more ▼]

The first committed step in the biosynthesis of L-ascorbate from D-glucose in plants requires conversion of GDP-L-galactose to L-galactose 1-phosphate by a previously unidentified enzyme. Here we show that the protein encoded by VTC2, a gene mutated in vitamin C-deficient Arabidopsis thaliana strains, is a member of the GalT/Apa1 branch of the histidine triad protein superfamily that catalyzes the conversion of GDP-L-galactose to L-galactose 1-phosphate in a reaction that consumes inorganic phosphate and produces GDP. In characterizing recombinant VTC2 from A. thaliana as a specific GDP-L-galactose/GDP-D-glucose phosphorylase, we conclude that enzymes catalyzing each of the ten steps of the Smirnoff-Wheeler pathway from glucose to ascorbate have been identified. Finally, we identify VTC2 homologs in plants, invertebrates, and vertebrates, suggesting that a similar reaction is used widely in nature. [less ▲]

Ligand binding and circular permutation modify residue interaction network in DHFR.

in PLoS computational biology (2007), 3(6), 117

Residue interaction networks and loop motions are important for catalysis in dihydrofolate reductase (DHFR). Here, we investigate the effects of ligand binding and chain connectivity on network ... [more ▼]

Residue interaction networks and loop motions are important for catalysis in dihydrofolate reductase (DHFR). Here, we investigate the effects of ligand binding and chain connectivity on network communication in DHFR. We carry out systematic network analysis and molecular dynamics simulations of the native DHFR and 19 of its circularly permuted variants by breaking the chain connections in ten folding element regions and in nine nonfolding element regions as observed by experiment. Our studies suggest that chain cleavage in folding element areas may deactivate DHFR due to large perturbations in the network properties near the active site. The protein active site is near or coincides with residues through which the shortest paths in the residue interaction network tend to go. Further, our network analysis reveals that ligand binding has "network-bridging effects" on the DHFR structure. Our results suggest that ligand binding leads to a modification, with most of the interaction networks now passing through the cofactor, shortening the average shortest path. Ligand binding at the active site has profound effects on the network centrality, especially the closeness. [less ▲]

Journées diocésaines de formation

Scientific Conference (2007, June 11)

Partial Least Squares Regression for Qualitative Variables

Scientific Conference (2007, June 01)

The ambivalence of self-controlled (motor) learning: A model-guided psychological analysis

in Beek, Peter; van de Langenberg, Rolf (Eds.) European Workshop on Movement Science - Book of Abstracts (2007, June)

The use of strategies in motor learning: Validation of a new questionnaire.

Poster (2007, June)