References of "2007"
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See detailThe modular organization of domain structures: insights into protein-protein binding.
del Sol Mesa, Antonio UL; Carbonell, Pablo

in PLoS computational biology (2007), 3(12), 239

Domains are the building blocks of proteins and play a crucial role in protein-protein interactions. Here, we propose a new approach for the analysis and prediction of domain-domain interfaces. Our method ... [more ▼]

Domains are the building blocks of proteins and play a crucial role in protein-protein interactions. Here, we propose a new approach for the analysis and prediction of domain-domain interfaces. Our method, which relies on the representation of domains as residue-interacting networks, finds an optimal decomposition of domain structures into modules. The resulting modules comprise highly cooperative residues, which exhibit few connections with other modules. We found that non-overlapping binding sites in a domain, involved in different domain-domain interactions, are generally contained in different modules. This observation indicates that our modular decomposition is able to separate protein domains into regions with specialized functions. Our results show that modules with high modularity values identify binding site regions, demonstrating the predictive character of modularity. Furthermore, the combination of modularity with other characteristics, such as sequence conservation or surface patches, was found to improve our predictions. In an attempt to give a physical interpretation to the modular architecture of domains, we analyzed in detail six examples of protein domains with available experimental binding data. The modular configuration of the TEM1-beta-lactamase binding site illustrates the energetic independence of hotspots located in different modules and the cooperativity of those sited within the same modules. The energetic and structural cooperativity between intramodular residues is also clearly shown in the example of the chymotrypsin inhibitor, where non-binding site residues have a synergistic effect on binding. Interestingly, the binding site of the T cell receptor beta chain variable domain 2.1 is contained in one module, which includes structurally distant hot regions displaying positive cooperativity. These findings support the idea that modules possess certain functional and energetic independence. A modular organization of binding sites confers robustness and flexibility to the performance of the functional activity, and facilitates the evolution of protein interactions. [less ▲]

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See detailModular architecture of protein structures and allosteric communications: potential implications for signaling proteins and regulatory linkages.
del Sol Mesa, Antonio UL; Arauzo-Bravo, Marcos J.; Amoros, Dolors et al

in Genome biology (2007), 8(5), 92

BACKGROUND: Allosteric communications are vital for cellular signaling. Here we explore a relationship between protein architectural organization and shortcuts in signaling pathways. RESULTS: We show that ... [more ▼]

BACKGROUND: Allosteric communications are vital for cellular signaling. Here we explore a relationship between protein architectural organization and shortcuts in signaling pathways. RESULTS: We show that protein domains consist of modules interconnected by residues that mediate signaling through the shortest pathways. These mediating residues tend to be located at the inter-modular boundaries, which are more rigid and display a larger number of long-range interactions than intra-modular regions. The inter-modular boundaries contain most of the residues centrally conserved in the protein fold, which may be crucial for information transfer between amino acids. Our approach to modular decomposition relies on a representation of protein structures as residue-interacting networks, and removal of the most central residue contacts, which are assumed to be crucial for allosteric communications. The modular decomposition of 100 multi-domain protein structures indicates that modules constitute the building blocks of domains. The analysis of 13 allosteric proteins revealed that modules characterize experimentally identified functional regions. Based on the study of an additional functionally annotated dataset of 115 proteins, we propose that high-modularity modules include functional sites and are the basic functional units. We provide examples (the Galphas subunit and P450 cytochromes) to illustrate that the modular architecture of active sites is linked to their functional specialization. CONCLUSION: Our method decomposes protein structures into modules, allowing the study of signal transmission between functional sites. A modular configuration might be advantageous: it allows signaling proteins to expand their regulatory linkages and may elicit a broader range of control mechanisms either via modular combinations or through modulation of inter-modular linkages. [less ▲]

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See detailDie Jugend in Esch. Lebenslagen, Freizeitinteressen und Freundesgruppen
Heinen, Andreas UL; Boultgen, Danielle; Willems, Helmut UL

Report (2007)

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See detailEntropy of bi-capacities
Kojadinovic, Ivan; Marichal, Jean-Luc UL

in European Journal of Operational Research (2007), 178(1), 168-184

In the context of multicriteria decision making whose aggregation process is based on the Choquet integral, bi-capacities can be regarded as a natural extension of capacities when the underlying ... [more ▼]

In the context of multicriteria decision making whose aggregation process is based on the Choquet integral, bi-capacities can be regarded as a natural extension of capacities when the underlying evaluation scale is bipolar. The notion of entropy, recently generalized to capacities to measure their uniformity, is now extended to bi-capacities. We show that the resulting entropy measure has a very natural interpretation in terms of the Choquet integral and satisfies many natural properties that one would expect from an entropy measure. [less ▲]

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See detailHumanbezug in der Fort- und Weiterbildung von Erwachsenen
Schumacher, Anette UL

Presentation (2007, April)

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See detailThe Refugees and Article 56 of the 1971 Constitution
Al Hajjaji, Shams Al Din UL

Bachelor/master dissertation (2007)

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See detailDas dreidimensionale Kommunikationsdreieck. Herausforderungen und Chancen der Zusammenarbeit zwischen den Akteuren des Jugendbereichs
Milmeister, Marianne UL

Article for general public (2007)

Seit einigen Jahren treiben der Europarat und die Europäische Union die Vernetzung und den Dialog zwischen den Akteuren der Politik, Wissenschaft und Praxis im Jugendbereich voran. Das Ziel ist einerseits ... [more ▼]

Seit einigen Jahren treiben der Europarat und die Europäische Union die Vernetzung und den Dialog zwischen den Akteuren der Politik, Wissenschaft und Praxis im Jugendbereich voran. Das Ziel ist einerseits eine wissensbasierte Jugendpolitik, andererseits eine praxis- und politikrelevante Jugendforschung. In mehreren Hinsichten bietet diese Zusammenarbeit Chancen, aber auch Herausforderungen und Schwierigkeiten. [less ▲]

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See detail3D Mixed Invariant and its Application on Object Classification
Feng, Shuo; Aouada, Djamila UL; Krim, Hamid et al

in IEEE International Conference on Acoustics, Speech and Signal Processing, 2007. ICASSP 2007 (2007, April)

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See detailUnderstanding the functional neuroanatomy of acquired prosopagnosia
Sorger, Bettina; Goebel, Rainer; Schiltz, Christine UL et al

in NeuroImage (2007), 35(2), 836-852

One of the most remarkable disorders following brain damage is prosopagnosia, the inability to recognize faces. While a number of cases of prosopagnosia have been described at the behavioral level, the ... [more ▼]

One of the most remarkable disorders following brain damage is prosopagnosia, the inability to recognize faces. While a number of cases of prosopagnosia have been described at the behavioral level, the functional neuroanatomy of this face recognition impairment, and thus the brain regions critically involved in normal face recognition, has never been specified in great detail. Here, we used anatomical and functional magnetic resonance imaging (fMRI) to present the detailed functional neuroanatomy of a single case of acquired prosopagnosia (PS; Rossion, B., Caldara, R., Seghier, M., Schuller, A.-M., Lazeyras, F., Mayer, E., 2003a. A network of occipito-temporal face-sensitive areas besides the right middle fusiform gyrus is necessary for normal face processing. Brain 126, 2381-95; Rossion, B., Joyce, C.A., Cottrell, G.W., Tarr, M.J., 2003b. Early lateralization and orientation tuning for face, word, and object processing in the visual cortex. Neuroimage 20, 1609-24) with normal object recognition. First, we clarify the exact anatomical location and extent of PS' lesions in relation to (a) retinotopic cortex, (b) face-preferring regions, and (c) other classical visual regions. PS' main lesion - most likely causing her prosopagnosia - is localized in the posterior part of the right ventral occipitotemporal cortex. This lesion causes a left superior paracentral scotoma, as frequently observed in cases of prosopagnosia. While the borders of the early visual areas in the left hemisphere could be delineated well, the extensive posterior right-sided lesion hampered a full specification of the cortical representation of the left visual field. Using multiple scanning runs, face-preferring activation was detected within the right middle fusiform gyrus (MFG) in the so-called 'fusiform face area' ('FFA'), but also in the left inferior occipital gyrus (left 'OFA'), and in the right posterior superior temporal sulcus (STS). The dorsal part of the lateral occipital complex (LOC) and the human middle temporal cortex (hMT+/V5) were localized bilaterally. The color-preferring region V4/V8 was localized only in the left hemisphere. In the right hemisphere, the posterior lesion spared the ventral part of LOC, a region that may be critical for the preserved object recognition abilities of the patient, and the restriction of her deficit to the category of faces. The presumptive functions of both structurally damaged and preserved regions are discussed and new hypotheses regarding the impaired and preserved abilities of the patient during face and non-face object processing are derived. Fine-grained neurofunctional analyses of brain-damaged single cases with isolated recognition deficits may considerably improve our knowledge of the brain regions critically involved in specific visual functions, such as face recognition. [less ▲]

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See detailHuman centered processes: Toward a naturalistic decision making paradigm
Bisdorff, Raymond UL; Lundberg, Gustav; Marichal, Jean-Luc UL

in European Journal of Operational Research (2007), 177(3), 1313-2118

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See detailk-intolerant capacities and Choquet integrals
Marichal, Jean-Luc UL

in European Journal of Operational Research (2007), 177(3), 1453-1468

We define an aggregation function to be (at most) k-intolerant if it is bounded from above by its kth lowest input value. Applying this definition to the discrete Choquet integral and its underlying ... [more ▼]

We define an aggregation function to be (at most) k-intolerant if it is bounded from above by its kth lowest input value. Applying this definition to the discrete Choquet integral and its underlying capacity, we introduce the concept of k-intolerant capacities which, when varying k from 1 to n, cover all the possible capacities on n objects. Just as the concepts of k-additive capacities and p-symmetric capacities have been previously introduced essentially to overcome the problem of computational complexity of capacities, k-intolerant capacities are proposed here for the same purpose but also for dealing with intolerant or tolerant behaviors of aggregation. We also introduce axiomatically indices to appraise the extent to which a given capacity is k-intolerant and we apply them on a particular recruiting problem. [less ▲]

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See detailGeschlecht, Bewegung und Lernstrategien: Nutzen Frauen und Männer unterschiedliche Strategien, um Bewegungsfertigkeiten zu erlernen?
Bund, Andreas UL

in Hartmann-Tews, Ilse; Dahmen, Britt (Eds.) Sportwissenschaftliche Geschlechterforschung im Spannungsfeld von Theorie, Politik und Praxis (2007, March)

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See detailWelchen Einfluss haben Stereotypizität und Kohärenz auf das Verstehen einer Personbeschreibung
Ochs, Nadine; Renaud, Dagmar; Krolak-Schwerdt, Sabine UL

Scientific Conference (2007, March)

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See detailOptimization of load carrying capacity of antibiotic loaded hip interim-prothesis
Thielen, T.; Maas, S.; Zuerbes, A. et al

Scientific Conference (2007, March)

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See detailTowards safer foods and more democratic decisions: Is this a contradictory goal?
König, Ariane UL

in Oléagineux, Corps Gras, Lipides (2007), 14(2), 92-99

Since the mid-1990s and the BSE crisis food safety policy is a priority of the EU. In practise there are however many hurdles towards implementing principles of improved governance, such as transparency ... [more ▼]

Since the mid-1990s and the BSE crisis food safety policy is a priority of the EU. In practise there are however many hurdles towards implementing principles of improved governance, such as transparency and greater participation, especially at EU-level. This paper presents the work of the SAFE FOODS prospect towards the development an improved framework for risk analysis. The final aim is to develop concrete recommendations on how to facilitate coordination between risk assessors, risk managers and stakeholders across the EU, and to keep methods for risk assessment apace with developments in the life sciences. [less ▲]

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See detailAssociation between leisure time physical activity and health-related quality of life changes over time.
Tessier, Sabrina; Vuillemin, Anne; Bertrais, Sandrine et al

in Preventive Medicine (2007), 44(3), 202-208

Objective This study aimed to assess whether changes in leisure-time physical activity over 3 years are associated with changes in health-related quality of life. Method Among the adults enrolled in the ... [more ▼]

Objective This study aimed to assess whether changes in leisure-time physical activity over 3 years are associated with changes in health-related quality of life. Method Among the adults enrolled in the Supplementation en VItamines et Minéraux Antioxidants study in France, 3891 completed the Modifiable Activity Questionnaire to assess leisure-time physical activity and the Medical Outcomes Study 36-item Short-Form to assess health-related quality of life in 1998 and 2001. Multivariate analyses involving logistic and linear regressions determined the association between changes in leisure-time physical activity and changes in health-related quality of life. Results Over 3 years, increased leisure-time physical activity was associated with high scores in health-related quality of life dimensions: physical functioning, mental health, vitality for both sexes as well as social functioning for women only. An increase of 1 h per week of leisure-time physical activity was associated with a 0.17- and 0.39-point increase in the vitality dimension in men and women, respectively. The mental component score was also increased in women increasing their leisure-time physical activity. Conclusion The long-term association between leisure-time physical activity and health-related quality of life changes is limited and has little clinical significance, especially for men and for the physical health-related quality of life dimensions. The long-term association needs to be further explored before formulating public health recommendations. [less ▲]

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See detailComparison meaningful aggregation functions: a state of the art
Marichal, Jean-Luc UL

Presentation (2007, February 14)

In many domains we are faced with the problem of aggregating a collection of numerical readings to obtain a mean or typical value. Such an aggregation problem is becoming more and more present in an ... [more ▼]

In many domains we are faced with the problem of aggregating a collection of numerical readings to obtain a mean or typical value. Such an aggregation problem is becoming more and more present in an increasing number of areas not only of mathematics or physics, but also of engineering, economical, social, and other sciences. Various aggregation functions and processes have already been proposed in the literature and many others are still to be designed to fulfill newer and newer requirements. Studies on the aggregation problem have shown that the choice of the aggregation function is far from being arbitrary and should be based upon properties dictated by the framework in which the aggregation is performed. One of the main concerns when choosing an appropriate function is to take into account the scale types of the variables being aggregated. On this issue it was observed that the general form of the aggregation function is greatly restricted if we know the scale types of the dependent and independent variables. For instance, if all the variables define a common ordinal scale, it is clear that any relevant aggregation function cannot be constructed from usual arithmetic operations, unless these operations involve only order. Thus, computing the arithmetic mean is forbidden whereas the median or any order statistic is permitted. We present a state of the art survey on the known axiomatizations of aggregation functions mapping ordinal scales into an ordinal scale. We show that, in this ordinal context, the family of possible aggregation functions is rather poor, more or less consisting of order statistics and lattice polynomials. [less ▲]

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See detailOn maximal independent sets in circulant digraphs
Bisdorff, Raymond UL

E-print/Working paper (2007)

In this research note we introduce St-Nicolas graphs, i.e. circulant digraphs showing exactly n maximal independent sets, isomorph under the digraph’s automorphisms group. This class of digraphs represent ... [more ▼]

In this research note we introduce St-Nicolas graphs, i.e. circulant digraphs showing exactly n maximal independent sets, isomorph under the digraph’s automorphisms group. This class of digraphs represent a generalisation of Andrásfai graphs with interesting links to finite group theory. [less ▲]

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