References of "2006"
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See detailPerkolation in Netzwerken aus Nanoröhrchen
Schilling, Tanja UL

Presentation (2006, May 19)

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See detailGeoGebra
Hohenwarter, Markus; Kreis, Yves UL

Software (2006)

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See detailResidues crucial for maintaining short paths in network communication mediate signaling in proteins.
del Sol Mesa, Antonio UL; Fujihashi, Hirotomo; Amoros, Dolors et al

in Molecular systems biology (2006), 2

Here, we represent protein structures as residue interacting networks, which are assumed to involve a permanent flow of information between amino acids. By removal of nodes from the protein network, we ... [more ▼]

Here, we represent protein structures as residue interacting networks, which are assumed to involve a permanent flow of information between amino acids. By removal of nodes from the protein network, we identify fold centrally conserved residues, which are crucial for sustaining the shortest pathways and thus play key roles in long-range interactions. Analysis of seven protein families (myoglobins, G-protein-coupled receptors, the trypsin class of serine proteases, hemoglobins, oligosaccharide phosphorylases, nuclear receptor ligand-binding domains and retroviral proteases) confirms that experimentally many of these residues are important for allosteric communication. The agreement between the centrally conserved residues, which are key in preserving short path lengths, and residues experimentally suggested to mediate signaling further illustrates that topology plays an important role in network communication. Protein folds have evolved under constraints imposed by function. To maintain function, protein structures need to be robust to mutational events. On the other hand, robustness is accompanied by an extreme sensitivity at some crucial sites. Thus, here we propose that centrally conserved residues, whose removal increases the characteristic path length in protein networks, may relate to the system fragility. [less ▲]

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See detailTraces de mémoire, mémoire des traces
Cicotti, Claudio UL

Article for general public (2006)

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See detailMotivations- und Emotionsverläufe beim selbstgesteuerten Bewegungslernen
Bund, Andreas UL

in Halberschmidt, Barbara; Strauß, Bernd (Eds.) Elf Freunde sollt ihr sein!? (2006, May)

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See detailComparison and combination of CHAMP and GRACE data for gravity field analysis
Weigelt, Matthias UL; El-Habiby, M. M.; Sideris, M. G. et al

Scientific Conference (2006, May)

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See detailManganese-enhanced magnetic resonance imaging for in vivo assessment of damage and functional improvement following spinal cord injury in mice.
Stieltjes B,; Klussmann S; Bock M et al

in Magn Reson Med (2006), 5

In past decades, much effort has been invested in developing therapies for spinal injuries. Lack of standardization of clinical read-out measures, however, makes direct comparison of experimental ... [more ▼]

In past decades, much effort has been invested in developing therapies for spinal injuries. Lack of standardization of clinical read-out measures, however, makes direct comparison of experimental therapies difficult. Damage and therapeutic effects in vivo are routinely evaluated using rather subjective behavioral tests. Here we show that manganese-enhanced magnetic resonance imaging (MEMRI) can be used to examine the extent of damage following spinal cord injury (SCI) in mice in vivo. Injection of MnCl2 solution into the cerebrospinal fluid leads to manganese uptake into the spinal cord. Furthermore, after injury MEMRI-derived quantitative measures correlate closely with clinical locomotor scores. Improved locomotion due to treating the detrimental effects of SCI with an established therapy (neutralization of CD95Ligand) is reflected in an increase of manganese uptake into the injured spinal cord. Therefore, we demonstrate that MEMRI is a sensitive and objective tool for in vivo visualization and quantification of damage and functional improvement after SCI. Thus, MEMRI can serve as a reproducible surrogate measure of the clinical status of the spinal cord in mice, potentially becoming a standard approach for evaluating experimental therapies. [less ▲]

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See detailTeaching with trade books: Wonderful, wiggly worms
Siry, Christina UL

in Science and Children (2006), 43(7), 14-16

The article presents information about teaching worm behavior in a science classroom with the help of books like "Wiggling Worms at Work," by Wendy Pfeffer and "Squirmy Wormy Composters," by Bobbie Kalman ... [more ▼]

The article presents information about teaching worm behavior in a science classroom with the help of books like "Wiggling Worms at Work," by Wendy Pfeffer and "Squirmy Wormy Composters," by Bobbie Kalman and Janine Schaub. While the former book helps students understand the role organisms play in an ecosystem, the latter provides reference materials that can be used by students in designing experiments. With the examination of worms' body structure and behavior, students gain an appreciation of the ecological importance of worms. Experimenting with living creature in the classroom, it is equally important to follow appropriate safety guidelines including washing hands before and after handling worms. One such K-3 grade experiment is to create a worm jar to observe the tunneling behavior of worms. [less ▲]

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See detailLa transition de l’école à la vie active au Luxembourg
Houssemand, Claude UL

Scientific Conference (2006, April)

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See detailHigh-latitude local gravity field recovery from CHAMP with least-squares collocation
Weigelt, Matthias UL; Sideris, M. G.; Sneeuw, N.

Poster (2006, April)

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See detailOn the accelerometer calibration onboard GRACE
Raizner, C.; Weigelt, Matthias UL; Sideris, M. G.

Scientific Conference (2006, April)

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See detailGravity Field Recovery from satellite-to-satellite tracking missions
Weigelt, Matthias UL; Sideris, M. G.; Sneeuw, N.

Scientific Conference (2006, April)

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See detailGlucuronate, the precursor of vitamin C, is directly formed from UDP-glucuronate in liver
Linster, Carole UL; Van Schaftingen, Emile

in FEBS Journal (2006), 273(7), 1516-27

The conversion of UDP-glucuronate to glucuronate, usually thought to proceed by way of glucuronate 1-phosphate, is a site for short-term regulation of vitamin C synthesis by metyrapone and other ... [more ▼]

The conversion of UDP-glucuronate to glucuronate, usually thought to proceed by way of glucuronate 1-phosphate, is a site for short-term regulation of vitamin C synthesis by metyrapone and other xenobiotics in isolated rat hepatocytes. Our purpose was to explore the mechanism of this effect in cell-free systems. Metyrapone and other xenobiotics stimulated, by approximately threefold, the formation of glucuronate from UDP-glucuronate in liver extracts enriched with ATP-Mg, but did not affect the formation of glucuronate 1-phosphate from UDP-glucuronate or the conversion of glucuronate 1-phosphate to glucuronate. This and other data indicated that glucuronate 1-phosphate is not an intermediate in glucuronate formation from UDP-glucuronate, suggesting that this reaction is catalysed by a 'UDP-glucuronidase'. UDP-glucuronidase was present mainly in the microsomal fraction, where its activity was stimulated by UDP-N-acetylglucosamine, known to stimulate UDP-glucuronosyltransferases by enhancing the transport of UDP-glucuronate across the endoplasmic reticulum membrane. UDP-glucuronidase and UDP-glucuronosyltransferases displayed similar sensitivities to various detergents, which stimulated at low concentrations and generally inhibited at higher concentrations. Substrates of glucuronidation inhibited UDP-glucuronidase activity, suggesting that the latter is contributed by UDP-glucuronosyltransferase(s). Inhibitors of beta-glucuronidase and esterases did not affect the formation of glucuronate, arguing against the involvement of a glucuronidation-deglucuronidation cycle. The sensitivity of UDP-glucuronidase to metyrapone and other stimulatory xenobiotics was lost in washed microsomes, even in the presence of ATP-Mg, but it could be restored by adding a heated liver high-speed supernatant or CoASH. In conclusion, glucuronate formation in liver is catalysed by a UDP-glucuronidase which is closely related to UDP-glucuronosyltransferases. Metyrapone and other xenobiotics stimulate UDP-glucuronidase by antagonizing the inhibition exerted, presumably indirectly, by a combination of ATP-Mg and CoASH. [less ▲]

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See detailAxiomatic characterizations of probabilistic and cardinal-probabilistic interaction indices
Fujimoto, Katsushige; Kojadinovic, Ivan; Marichal, Jean-Luc UL

in Games and Economic Behavior (2006), 55(1), 72-99

In the framework of cooperative game theory, the concept of interaction index, which can be regarded as an extension of that of value, has been recently proposed to measure the interaction phenomena among ... [more ▼]

In the framework of cooperative game theory, the concept of interaction index, which can be regarded as an extension of that of value, has been recently proposed to measure the interaction phenomena among players. Axiomatizations of two classes of interaction indices, namely probabilistic interaction indices and cardinal-probabilistic interaction indices, generalizing probabilistic values and semivalues, respectively, are first proposed. The axioms we utilize are based on natural generalizations of axioms involved in the axiomatizations of values. In the second half of the paper, existing instances of cardinal-probabilistic interaction indices encountered thus far in the literature are also axiomatized. [less ▲]

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See detailCCK: An Improved Coordinated Checkpoint/Rollback Protocol for Dataflow Applications in Kaapi
Besseron, Xavier UL; Jafar, Samir; Gautier, Thierry et al

in 2006 2nd International Conference on Information & Communication Technologies (2006, April)

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See detailImpaired face discrimination in acquired prosopagnosia is associated with abnormal response to individual faces in the right middle fusiform gyrus
Schiltz, Christine UL; Sorger, Bettina; Caldara, Roberto et al

in Cerebral Cortex (2006), 16(4), 574-586

The middle fusiform gyrus (MFG) and the inferior occipital gyrus (IOG) are activated by both detection and identification of faces. Paradoxically, patients with acquired prosopagnosia following lesions to ... [more ▼]

The middle fusiform gyrus (MFG) and the inferior occipital gyrus (IOG) are activated by both detection and identification of faces. Paradoxically, patients with acquired prosopagnosia following lesions to either of these regions in the right hemisphere cannot identify faces, but can still detect faces. Here we acquired functional magnetic resonance imaging (fMRI) data during face processing in a patient presenting a specific deficit in individual face recognition, following lesions encompassing the right IOG. Using an adaptation paradigm we show that the fMRI signal in the rMFG of the patient, while being larger in response to faces as compared to objects, does not differ between conditions presenting identical and distinct faces, in contrast to the larger response to distinct faces observed in controls. These results suggest that individual discrimination of faces critically depends on the integrity of both the rMFG and the rIOG, which may interact through re-entrant cortical connections in the normal brain. [less ▲]

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See detailLes armées de mercenaires allemands au 16e siècle
Weis, Monique UL

Conference given outside the academic context (2006)

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See detailTreeDet: a web server to explore sequence space.
Carro, Angel; Tress, Michael; de Juan, David et al

in Nucleic acids research (2006), 34(Web Server issue), 110-5

The TreeDet (Tree Determinant) Server is the first release of a system designed to integrate results from methods that predict functional sites in protein families. These methods take into account the ... [more ▼]

The TreeDet (Tree Determinant) Server is the first release of a system designed to integrate results from methods that predict functional sites in protein families. These methods take into account the relation between sequence conservation and evolutionary importance. TreeDet fully analyses the space of protein sequences in either user-uploaded or automatically generated multiple sequence alignments. The methods implemented in the server represent three main classes of methods for the detection of family-dependent conserved positions, a tree-based method, a correlation based method and a method that employs a principal component analyses coupled to a cluster algorithm. An additional method is provided to highlight the reliability of the position in the alignments. The server is available at http://www.pdg.cnb.uam.es/servers/treedet. [less ▲]

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