Michel Chion, Un art sonore, le cinéma, 2003

in Nouveaux Actes Sémiotiques (2005), (98-100), 56-62

Forum non Conveniens and the Brussels Convention

in International Law and Comparative Law Quarterly (2005)

Regulation of nitrate and nitrite respiration in γ-proteobacteria: a comparative genomics study

in Molecular Biology (2005), 39(5), 727-740

Nitrate and nitrite are the most preferable electron acceptors in the absence of molecular oxygen. In the γ-proteobacterium Escherichia coli, nitrate and nitrite respiration is regulated by two homologous ... [more ▼]

Nitrate and nitrite are the most preferable electron acceptors in the absence of molecular oxygen. In the γ-proteobacterium Escherichia coli, nitrate and nitrite respiration is regulated by two homologous tran- scription factors, NarL and NarP. Although this regulatory system was a subject of intensive research for more than 20 years, many key issues, including the structure of the NarL-binding site, are still unclear. Comparative genomics analysis showed that only NarP is responsible for regulation in most γ-proteobacteria. The NarP reg- ulon was studied in ten genomes. Although its structure considerably differs among some genomes, the mech- anism regulating the nitrate and nitrite reduction genes is highly conserved. A correlation was observed between the evolutionary changes in the nitrate and nitrite respiration system and the relevant regulatory system. Poten- tial NarP-binding sites were found upstream of the gene for the global regulator FNR and the sydAB, mdh, and sucAB aerobic metabolism genes. It was assumed on the basis of this evidence that the role of NarP in regulat- ing respiration changed during evolution. In total, 35 new operons were assigned to the generalized NarP reg- ulon. Autoregulation of the narQP operon was suggested for bacteria of the family Vibrionaceae. [less ▲]

A Gibbs sampler for identification of symmetrically structured, spaced DNA motifs with improved estimation of the signal length

in Bioinformatics (2005), 21(10), 2240-2245

Motivation: Transcription regulatory protein factors often bind DNA as homo-dimers or hetero-dimers. Thus they recognize structured DNA motifs that are inverted or direct repeats or spaced motif pairs ... [more ▼]

Motivation: Transcription regulatory protein factors often bind DNA as homo-dimers or hetero-dimers. Thus they recognize structured DNA motifs that are inverted or direct repeats or spaced motif pairs. However, these motifs are often difficult to identify owing to their high divergence. The motif structure included explicitly into the motif recognition algorithm improves recognition efficiency for highly divergent motifs as well as estimation of motif geometric parameters. Result: We present a modification of the Gibbs sampling motif extraction algorithm, SeSiMCMC (Sequence Similarities by Markov Chain Monte Carlo), which finds structured motifs of these types, as well as non-structured motifs, in a set of unaligned DNA sequences. It employs improved estimators of motif and spacer lengths. The probability that a sequence does not contain any motif is accounted for in a rigorous Bayesian manner. We have applied the algorithm to a set of upstream regions of genes from two Escherichia coli regulons involved in respiration. We have demonstrated that accounting for a symmetric motif structure allows the algorithm to identify weak motifs more accurately. In the examples studied, ArcA binding sites were demonstrated to have the structure of a direct spaced repeat, whereas NarP binding sites exhibited the palindromic structure. Availability: The WWW interface of the program, its FreeBSD (4.0) and Windows 32 console executables are available at http://bioinform.genetika.ru/SeSiMCMC [less ▲]

SCTL: A StateChart Transformation Language for Test Sets Reduction

in ERCIM Workshop on Dependable Software Intensive Embedded Systems, workshop of the 31st EUROMICRO Conference on Software Engineering and Advanced Appli (2005)

Specification and testing activities are key phases in embedded systems development life cycles. In specification-based testing approaches, test cases are solely generated from the system specification ... [more ▼]

Specification and testing activities are key phases in embedded systems development life cycles. In specification-based testing approaches, test cases are solely generated from the system specification. Test cases are often too numerous to be executed exhaustively. In practice, test engineers often select test cases based on informal approximations. We aim at improving these activities by formulating abstraction hypotheses on system specifications, to reduce generated test sets. Our general application framework is the automotive industry, and we aim the specific domain of small-sized real-time embedded systems that must be highly reliable. The main result presented in this paper is a model transformation language that helps test engineers to select test cases based on system specifications. [less ▲]

Nicola Dusi, Il cinema come traduzione, 2003

in Nouveaux Actes Sémiotiques (2005), (98-100), 62-70

A cross-sectional international survey of continuous subcutaneous insulin infusion (CSII) in 377 children and adolescents with type 1 diabetes mellitus from 10 countries

in Pediatric Diabetes (2005), 6

OBJECTIVE: To document current practices using continuous subcutaneous insulin infusion (CSII) by downloading electronically the 90-d pump data held within the pump memory and relating that to clinical ... [more ▼]

OBJECTIVE: To document current practices using continuous subcutaneous insulin infusion (CSII) by downloading electronically the 90-d pump data held within the pump memory and relating that to clinical data from children and adolescents in different pediatric diabetes centers from Europe and Israel. METHODS: Data of patients (1-18 yr) treated with CSII in 23 centers from nine European countries and Israel were recorded with the encapture software (PEC International, Frankfurt, Germany). The number of patients who participated was 377 (48% female; mean diabetes duration +/- SD: 6.8 +/- 3.7 yr; age: 12.9 +/- 3.8 yr, preschool n = 33; prepubertal n = 95; adolescent n = 249; CSII duration: 1.6 +/- 1.2 yr; local HbA1c: 8.1 +/- 1.2%). RESULTS: The total insulin dose was lower than previously reported for injection therapy (0.79 +/- 0.20 U/kg/d). Covariance coefficient of daily total insulin was high in all age groups (adolescents 19 +/- 9%, prepubertal 18 +/- 8 and preschool 17 +/- 8). The distribution of basal insulin infusion rates over 24 hr (48 +/- 12% of total dose) varied significantly between centers and age groups. The number of boluses per day (7 +/- 3) was not significantly different between the age groups (average daily bolus amount: 0.42 +/- 0.16 U/kg). The rate of severe hypoglycemia (coma/convulsions) was 12.4 episodes per 100 patient-years and the number of diabetes-related hospital days was 124 per 100 patient-years. DISCUSSION: Pediatric CSII patients show a high variability in their insulin therapy. This relates both to age-dependent differences in the distribution of basal insulin as to the age-independent day-to-day variation in prandial insulin. [less ▲]

Ästhetische Erfahrung: Kunst und Pädagogik als dialektische Beziehung in den Jeux Dramatiques

in Grundschulmagazin (2005), 73(1), 37-40

Pokojné soužití právních systémů a mírotvorná úloha soudce v oblasti mezinárodního obchodu

in Právník (2005), 144(8), 837-858

Décision de la Cour de cassation, 1ère Civ., 30 juin 2004

in Clunet (2005)

Reconnaissance de mesures conservatoires étrangères.