References of "2005"
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See detailMobilizing Knowledge for Innovativeness
Von Krogh; Von Pierer, H; Voelpel, S et al

Scientific Conference (2005)

Detailed reference viewed: 41 (0 UL)
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See detailStrategizing the Innovation Meme
Voelpel, S; Leibold, M; Streb, Christoph Klaus UL

Scientific Conference (2005)

Detailed reference viewed: 52 (0 UL)
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See detailThe Innovation Meme: Managing Innovation Replicators for Organizational Fitness
Voelpel, S; Leibold, M; Streb, Christoph Klaus UL

in Journal of Change Management (2005), 5(1), 57-69

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See detailDafo, a multi-agent framework for decomposable functions optimization
Danoy, Grégoire UL; Bouvry, Pascal UL; Boissier, Olivier

in 9th International Conference on Knowledge-Based Intelligent Information and Engineering Systems (KES 2005) (2005)

Detailed reference viewed: 166 (7 UL)
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See detailMultiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation
Haan, Serge UL; Keller, J. F.; Behrmann, Iris UL et al

in Cellular Signalling (2005), 17(12), 1542-50

IL-6-type cytokines play an important role during inflammation and the immune response. In addition, they are involved in haematopoiesis, liver and neuronal regeneration, embryonic development and ... [more ▼]

IL-6-type cytokines play an important role during inflammation and the immune response. In addition, they are involved in haematopoiesis, liver and neuronal regeneration, embryonic development and fertility. We found that IL-6-type cytokine stimulation of cell lines and primary human macrophages results in a different distribution of the DNA-binding competent STAT dimer species in the cytosol and nucleus as demonstrated by electrophoretic mobility shift assays. In the absence of detergent, STAT3/STAT3, STAT1/STAT3 were the predominant species in the cytoplasm while STAT3/STAT3 was predominant in the nucleus. However, in detergent containing total cellular lysates and nuclear fractions prepared with detergent containing buffers, the STAT1/STAT1 homodimer was as prominent or even more prominent than STAT3/STAT3 and STAT1/STAT3. We were interested in the cause of this discrepancy since STAT1-regulated genes have not been described to be expressed upon IL-6-type cytokine stimulation. In addition to the more transient STAT1 activation, IL-6-type cytokines such as IL-6 and OSM lead to a much less efficient STAT1 activation compared to the potent STAT1 activators IFNgamma and IFNalpha. Studies with STAT1-deficient cells revealed that STAT1 activation does not seem to be an important competitive process to STAT3 activation arguing again for a very inefficient STAT1 activation upon IL-6-type cytokine stimulation. We also describe that pY-STAT3 is much more efficiently shuttled into the nucleus than pY-STAT1. [less ▲]

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See detailMechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases.
Sommer, Ulrike; Schmid, Christine; Sobota, Radoslaw M. et al

in Journal of Biological Chemistry (2005), 280(36), 31478-88

The suppressors of cytokine signaling (SOCS) are negative feedback inhibitors of cytokine signal transduction. SOCS3 is a key negative regulator of interleuking-6 (IL-6) signal transduction. Furthermore ... [more ▼]

The suppressors of cytokine signaling (SOCS) are negative feedback inhibitors of cytokine signal transduction. SOCS3 is a key negative regulator of interleuking-6 (IL-6) signal transduction. Furthermore, SOCS3 was shown to be phosphorylated upon treatment of cells with IL-2, and this has been reported to regulate its function and half-life. We set out to investigate whether SOCS3 phosphorylation may play a role in IL-6 signaling. Tyrosine-phosphorylated SOCS3 was detected upon treatment of mouse embryonic fibroblasts with IL-6. Interestingly, the observed SOCS3 phosphorylation does not require SOCS3 recruitment to phosphotyrosine (Tyr(P)) 759 of gp130, and the kinetics of SOCS3 phosphorylation do not match the activation kinetics of the Janus kinases. This suggests that other kinases may be involved in SOCS3 phosphorylation. Using Src and Janus kinase inhibitors as well as Src kinase-deficient mouse embryonic fibroblasts, we provide evidence that Src kinases, which we found to be constitutively active in these cells, are involved in the phosphorylation of IL-6-induced SOCS3. In addition, we found that receptor-tyrosine kinases such as platelet-derived growth factor receptor or epidermal growth factor receptor can very potently phosphorylate IL-6-induced SOCS3. Taken together, these results suggest that SOCS3 phosphorylation is not a JAK-mediated phenomenon but is dependent on the activity of other kinases such as Src kinases or receptor-tyrosine kinases, which can either be constitutively active or activated by an additional stimulus. [less ▲]

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See detailPolitik der Einfachheit : Stifters »Witiko«
Christians, Heiko; Kohns, Oliver UL

in Wirkendes Wort (2005), 55(3), 389-403

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See detailUniversität als Zeitvertreib? : J. G. Fichtes »Deducirter Plan einer zu Berlin zu errichtenden höheren Lehranstalt«
Kohns, Oliver UL

in Karschnia, Alexander; Kohns, Oliver; Kreuzer, Stefanie (Eds.) et al Zum Zeitvertreib : Politik – Institutionen – Lektüren – Bilder (2005)

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See detailAre STATS arginine-methylated?
Komyod, W.; Bauer, U. M.; Heinrich, P. C. et al

in Journal of Biological Chemistry (2005), 280(23), 21700-5

Transcription factors of the STAT (signal transducer and activator of transcription) family are important in signal transduction of cytokines. They are subject to post-translational modification by ... [more ▼]

Transcription factors of the STAT (signal transducer and activator of transcription) family are important in signal transduction of cytokines. They are subject to post-translational modification by phosphorylation on tyrosine and serine residues. Recent evidence suggested that STATs are methylated on a conserved arginine residue within the N-terminal region. STAT arginine methylation has been described to be important for STAT function and loss of arginine methylation was discussed to be involved in interferon resistance of cancer cells. Here we provide several independent lines of evidence indicating that the issue of arginine methylation of STATs has to be reassessed. First, we show that treatment of melanoma and fibrosarcoma cells with inhibitors used to suppress methylation (N-methyl-2-deoxyadenosine, adenosine, dl-homocysteine) had profound and rapid effects on phosphorylation of STAT1 and STAT3 but also on p38 and Erk signaling cascades which are known to cross-talk with the Jak/STAT pathway. Second, we show that anti-methylarginine antibodies did not precipitate specifically STAT1 or STAT3. Third, we show that mutation of Arg(31) to Lys led to destabilization of STAT1 and STAT3, implicating an important structural role of Arg(31). Finally, purified catalytically active protein arginine methyltransferases (PRMT1, -2, -3, -4, and -6) did not methylate STAT proteins, and cotransfection with PRMT1 did not affect STAT1-controlled reporter gene activity. Taken together, our data suggest the absence of arginine methylation of STAT1 and STAT3. [less ▲]

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See detailThe Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression
Radtke, S.; Haan, Serge UL; Jörissen, A. et al

in Journal of Biological Chemistry (2005), 280(27), 25760-8

The presence of a Src homology 2 (SH2) domain sequence similarity in the sequence of Janus kinases (Jaks) has been discussed since the first descriptions of these enzymes. We performed an in depth study ... [more ▼]

The presence of a Src homology 2 (SH2) domain sequence similarity in the sequence of Janus kinases (Jaks) has been discussed since the first descriptions of these enzymes. We performed an in depth study to determine the function of the Jak1 SH2 domain. We investigated the functionality of the Jak1 SH2 domain by stably reconstituting Jak1-defective human fibrosarcoma cells U4C with endogenous amounts of Jak1 in which the crucial arginine residue Arg466 within the SH2 domain has been replaced by lysine. This mutant still binds to the receptor subunits gp130 and OSMR. Moreover, the SH2 R466K mutation does not affect the subcellular distribution of Jak1 as assessed by cell fractionation and confocal microscopy of cells expressing endogenous levels of non-tagged or a yellow fluorescent protein (YFP)-tagged Jak1-R466K, respectively. Likewise, the signaling capacity of Jak1 was not affected by this point mutation. However, we found that the SH2 domain is structurally important for cytokine receptor binding and surface expression of the OSMR. [less ▲]

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See detailDie Lokalisation des Neurokinin 1-Rezeptors im Hüftgelenk von Patienten mit schmerzhafter Osteoarthrose.
Saxler, Guido; Löer, Franz; von Knoch, Marius et al

in Zeitschrift für Orthopadie und Ihre Grenzgebiete (2005), 143

Detailed reference viewed: 141 (0 UL)
See detailModernization and Social Transformation in Vietnam. Social capital formation and institution building
Klump, Rainer UL; Mutz, Gerhard

Book published by IFA, Institut für Asienkunde (2005)

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See detailIntroduction: Modernization and social transformation in Vietnam. Social capital formation and institution building
Klump, Rainer UL; Mutz, Gerhard; Benda, N.

in Klump, Rainer; Mutz, Gerhard (Eds.) Modernization and social transformation in Vietnam (2005)

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See detailFinancial constraints to private investment in Vietnam
Klump, Rainer UL; Bonschab, T.

in Klump, Rainer; Mutz, Gerhard (Eds.) Modernization and social transformation in Vietnam (2005)

Detailed reference viewed: 25 (0 UL)
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See detailDer Beitrag der Freiburger Kreise zum Konzept der Sozialen Marktwirtschaft
Klump, Rainer UL

in Goldschmidt, Nils (Ed.) Wirtschaft, Politik und Freiheit. Freiburger Wirtschaftswissenschaftler und der Widerstand (2005)

Detailed reference viewed: 36 (0 UL)
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See detailExclusion of the C/D box snoRNA gene cluster HBII-52 from a major role in Prader–Willi syndrome
Runte, Maren UL; Varon, R; Horn, D et al

in Human Genetics (2005), 116(3), 228-230

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See detailLa mort à Bruxelles, 1914 - 1918
Majerus, Benoît UL

in Cahiers d'Histoire du Temps Présent = Bijdragen tot de Eigentijdse Geschiedenis (2005), (15), 65--81

Detailed reference viewed: 136 (5 UL)
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See detailUnequal-sphere packing model for simulation of the uniaxially compressed iodine adlayer on Au(111)
Tkatchenko, Alexandre UL; Batina, Nikola

in JOURNAL OF PHYSICAL CHEMISTRY B (2005), 109(46), 21710-21715

A simple unequal-sphere packing (USP) model, based on pure geometrical principles, was applied to study the centered-rectangular iodine c(p x root 3)R30 degrees adlayer on the Au(111) surface, well-known ... [more ▼]

A simple unequal-sphere packing (USP) model, based on pure geometrical principles, was applied to study the centered-rectangular iodine c(p x root 3)R30 degrees adlayer on the Au(111) surface, well-known from surface X-ray structure (SXS), low energy electron diffraction (LEED) and scanning tunneling microscopy (STM) experiments. To reproduce the exact patterns observed in experiments, two selective conditions-minimum average adsorbate height and minimum adlayer roughness-were imposed. As a result, a series of adlayer patterns with c(p x root 3)R30 degrees symmetry (2.3 < p < 3), with precise structural details, including atomic registry and identification of the p-bisector as the most likely trajectory for the iodine adatom movement during the so-called uniaxial compression phenomenon, were identified. In addition, using the same model, the difference between the iodine adlayer arranged in hexagonal and centered-rectangular c(p x root 3)R30 degrees patterns, as in the case of Pt(111) and Au(111) surfaces, was investigated. Qualitative and quantitative comparison shows that iodine adatoms in these two arrangements differ significantly in atomic registry, distance from the substrate, and the adlayer corrugation. Our findings could be of special interest in the study of the nature of the iodine adatom bonding to different substrates (i.e., Au vs Pt). [less ▲]

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See detailDetailed characterization of (3X3) iodine adlayer on Pt(111) by unequal-sphere packing model
Tkatchenko, Alexandre UL; Batina, Nikola

in JOURNAL OF CHEMICAL PHYSICS (2005), 122(9),

A simple unequal-sphere packing model is applied to study the iodine (3x3) adlayer on the Pt(111) surface. By using a newly introduced parameter, defined as the average adsorbate height, three ... [more ▼]

A simple unequal-sphere packing model is applied to study the iodine (3x3) adlayer on the Pt(111) surface. By using a newly introduced parameter, defined as the average adsorbate height, three characteristic adlattices, (3x3)-sym, (3x3)-asym, and (3x3)-lin, have been selected and characterized in great detail, including the exact adatom registry. The (3x3)-sym iodine adlattice, observed in many experimental studies appears to be, on average, the closest one to the substrate surface. A special contour plot of average adsorbate height vs X and Y positions of the (3x3) iodine unit cell indicates the existence of two local minima which are related to preferential formation of (3x3)-sym and (3x3)-asym iodine adlattices. Our model gives good agreement with experimental findings, and explains the mechanism of preferential appearance of (3x3)-sym and (3x3)-asym structures. (C) 2005 American Institute of Physics. [less ▲]

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See detailRegionale Produktionskomplexe in der Automobilindustrie auch grenzüberschreitend? Das Beispiel Saarland / Lothringen.
Schulz, Christian UL; Dörrenbächer, Peter

in Geographische Rundschau (2005), 57(12), 20-26

Detailed reference viewed: 98 (0 UL)