The Divide in the Digital Divide: Race and Ethnic Differences in Computer Ownership, 1984-2003.”

Scientific Conference (2005, August)

La migration au fond de chacun de nous

Article for general public (2005)

Spatio-temporal activation of chromatin on the human CYP24 gene promoter in the presence of 1alpha,25-Dihydroxyvitamin D3

in Journal of Molecular Biology (2005), 350(1), 65-77

The vitamin D3 24-hydroxylase gene (CYP24) is one of the most strongly induced genes known. Despite this, its induction by the hormone 1alpha,25-dihydroxyvitamin D3 (1alpha,25OH2D3) has been characterized ... [more ▼]

The vitamin D3 24-hydroxylase gene (CYP24) is one of the most strongly induced genes known. Despite this, its induction by the hormone 1alpha,25-dihydroxyvitamin D3 (1alpha,25OH2D3) has been characterized only partially. Therefore, we monitored the spatio-temporal, 1alpha,25OH2D3-dependent chromatin acetylation status of the human CYP24 promoter by performing chromatin immunoprecipitation (ChIP) assays with antibodies against acetylated histone 4. This was achieved by performing PCR on 25 contiguous genomic regions spanning the first 7.7 kb of the promoter. ChIP assays using antibodies against the 1alpha,25OH2D3 receptor (VDR) revealed that, in addition to the proximal promoter, three novel regions further upstream associated with VDR. Combined in silico/in vitro screening identified in three of the four promoter regions sequences resembling known VDREs and reporter gene assays confirmed the inducibility of these regions by 1alpha,25OH2D3)=. In contrast, the fourth VDR-associated promoter region did not contain any recognizable classical VDRE that could account for the presence of the protein on this region. However, re-ChIP assays monitored on all four promoter regions simultaneous association of VDR with retinoid X receptor, coactivator, mediator and RNA polymerase II proteins. These proteins showed a promoter region-specific association pattern demonstrating the complex choreography of the CYP24 gene promoter activation over 300 minutes. Thus, this study reveals new information concerning the regulation of the CYP24 gene by 1alpha,25OH2D3, and is a demonstration of the simultaneous participation of multiple, structurally diverse response elements in promoter activation in a living cell. [less ▲]

An extension of the Shannon entropy to bi-capacities

in Proc. 3rd Int. Summer School on Aggregation Operators and their Applications (AGOP 2005), Lugano, Switzerland, July 10-15, 2005 (2005, July)

The notion of Shannon entropy, recently generalized to capacities, is extended to bi-capacities and its main properties are studied.

A complete description of comparison meaningful functions

in Proc. 3rd Int. Summer School on Aggregation Operators and their Applications (AGOP 2005), Lugano, Switzerland (2005, July)

Comparison meaningful functions acting on some real interval E are completely described as transformed coordinate projections on minimal invariant subsets. The case of monotone comparison meaningful ... [more ▼]

Comparison meaningful functions acting on some real interval E are completely described as transformed coordinate projections on minimal invariant subsets. The case of monotone comparison meaningful functions is further specified. Several already known results for comparison meaningful functions and invariant functions are obtained as consequences of our description. [less ▲]

Modeling Exception Handling: a UML2.0 Platform Independent Profile for CAA

in Proceedings of ECOOP 2005 Workshop on Exception Handling in Object Oriented Systems (2005, July)

Complex fault-tolerant distributed systems have a growing need of new functional and quality requirements. An immediate consequence of this is an increasing need of new methods for developing complex ... [more ▼]

Complex fault-tolerant distributed systems have a growing need of new functional and quality requirements. An immediate consequence of this is an increasing need of new methods for developing complex fault-tolerant distributed applications. Coordinated Atomic Actions (CAAs), making use of exception handling mechanism, offer an approach to ensure the needed requirements of reliability, availability and fault tolerance. Unfortunately, there is currently no method for the high-level modeling of such systems. In this paper, in order to offer an instrument for modeling exception handling, we propose a UML2.0 Platform Independent Profile for CAAs that allows designers to describe complex systems separating the specification from the implementation on a specific technology platform. [less ▲]

Analyse des besoins 2 pour le projet 'e-Learning pour les langues' de Quattropole (French manuscript)

Report (2005)

Introduction à l'analyse factorielle dynamique

Scientific Conference (2005, June 18)

Lerntagebücher als Instrumente der Förderung und Evaluierung selbständigen Lernens

in Gogoll, André; Menze-Sonneck, Andreas (Eds.) Qualität im Schulsport (2005, June)

Numerical Velocity determination and Calibration Methods for CHAMP Using the Energy Balance Approach

in Jekeli, Christopher; Bastos, Luisa; Fernandes, Joana (Eds.) Gravity, Geoid and Space Missions (2005, June)

More than two years of data of the champ satellite mission is available and the usage of the energy balance approach for global gravity field recovery has been successfully implemented by several groups ... [more ▼]

More than two years of data of the champ satellite mission is available and the usage of the energy balance approach for global gravity field recovery has been successfully implemented by several groups around the world. This paper addresses two important aspects of the data processing. First, high-quality gravity recovery requires numerical differentiation of kinematic positions. Two methods are investigated using simulated and real dynamic data. It is shown that a third order Taylor differentiator is sufficient to reach good results. Second drift due to the accelerometer bias has to be corrected. Two possible approaches are discussed: cross-over calibration on the one hand calibration w.r.t. a reference model on the other hand. Currently the crossover calibration fails due to the insufficient accuracy of the crossover determination whereas the calibration w.r.t. a reference model gives good results. [less ▲]