Early-stage folding in proteins (in silico) sequence-to-structure relation

in Journal of Biomedicine & Biotechnology (2005), 2005(2), 65-79

A sequence-to-structure library has been created based on the complete PDB database. The tetrapeptide was selected as a unit representing a well-defined structural motif. Seven structural forms were ... [more ▼]

A sequence-to-structure library has been created based on the complete PDB database. The tetrapeptide was selected as a unit representing a well-defined structural motif. Seven structural forms were introduced for structure classification. The early-stage folding conformations were used as the objects for structure analysis and classification. The degree of determinability was estimated for the sequence-to-structure and structure-to-sequence relations. Probability calculus and informational entropy were applied for quantitative estimation of the mutual relation between them. The structural motifs representing different forms of loops and bends were found to favor particular sequences in structure-to-sequence analysis. [less ▲]

L’accès à la psychothérapie/ aux soutiens psychologiques pour des personnes mentalement handicapées atteints des troubles du comportement; approches et obstacles d’une intervention efficace et fondée sur les besoins des personnes autoagressives;

Scientific Conference (2005)

Awareness of breathing: German language descriptors of respiratory sensations and their relationship with ventilatory adaptation to respiratory challenge

Scientific Conference (2005)

Heinrich von Ulmen (ca. 1175-1234) - Ein Kreuzfahrer zwischen Eifel und Mittelmeer

in Irsigler, Franz; Minn, Gisela (Eds.) Portrait einer europäischen Kernregion. Der Rhein-Maas-Raum in historischen Lebensbildern (2005)

Königtum - Fürsten - Städtebünde. Die Aussenbeziehungen der Stadt Worms im Spätmittelalter

in Bönnen, Gerold (Ed.) Geschichte der Stadt Worms (2005)

Online Forums and Deliberative Democracy

in Acta Politica (2005), 40

The Internet is rapidly becoming a part of the everyday lives of a majority of people in the Western world. People perform various activities on the Internet and one of them is discussing politics and ... [more ▼]

The Internet is rapidly becoming a part of the everyday lives of a majority of people in the Western world. People perform various activities on the Internet and one of them is discussing politics and society in so-called online forums. In this article, we present an overview of some of the empirical research that evaluates the quality of political conversations in online forums. In the first section, we distinguish research on Usenet groups, web-based political forums and e-consultation forums, and discuss some its findings. In the second section, we elaborate three original categories of variables that attempt to explain differences observed in the quality of deliberation. The third, more extensive section deals with methodological issues. It discusses the operationalisation of deliberative quality and the application of a set of criteria for the idealized public sphere to online conversations. In the conclusion, we present some objections to the previous research and offer some ideas for a more comprehensive approach to online forum analysis. [less ▲]

Itô's and Tanaka's type formulae for the stochastic heat equation: the linear case

in Journal of Functional Analysis (2005), 228(1), 114-143

Association between end-tidal pCO2 and negative affect in healthy individuals

in Psychophysiology (2005), 42

Genre et expression contrastée du bien-être des jeunes. Projet DJAB - Diversité des jeunes et accès au bien-être

in Milmeister, Marianne (Ed.) Aspects de la recherche jeunesse: Diversité et genre. Documents de la Journée CESIJE du 17 décembre 2004 (2005)

Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives.

in Bioorganic & Medicinal Chemistry Letters (2005), 15(23), 5247-52

A structure-based approach has been taken to develop 4'-substituted analogs of triclosan that target the key malarial enzyme Plasmodium falciparum enoyl acyl carrier protein reductase (PfENR). Many of ... [more ▼]

A structure-based approach has been taken to develop 4'-substituted analogs of triclosan that target the key malarial enzyme Plasmodium falciparum enoyl acyl carrier protein reductase (PfENR). Many of these compounds exhibit nanomolar potency against purified PfENR enzyme and modest (2-10microM) potency against in vitro cultures of drug-resistant and drug-sensitive strains of the P. falciparum parasite. X-ray crystal structures of nitro 29, aniline 30, methylamide 37, and urea 46 demonstrate the presence of hydrogen-bonding interactions with residues in the active site and point to future rounds of optimization to improve compound potency against purified enzyme and intracellular parasites. [less ▲]