References of "2005"
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See detailDe nouvelles orientations pour la politique européenne en matière de services financiers
Prüm, André UL

in Revue de Droit Bancaire et Financier (2005), (5), 3

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See detailSpannungsfeld Berufsdomäne - Wirkt sich die Tätigkeit in einer Männer- oder Frauendomäne negativ auf das Karriereverhalten von Frauen und Männern aus?
Sturny, Angelika; Krolak-Schwerdt, Sabine UL; Wintermantel, Margret

in Zeitschrift für Sozialmanagement (2005), 3

Anhand von drei empirischen Studien wurde überprüft, welchen Einfluss die Tätigkeit in einer geschlechtsspezifischen Berufsdomäne (z. B. in einer Männer oder Frauendomäne) auf die Wahrnehmung und das ... [more ▼]

Anhand von drei empirischen Studien wurde überprüft, welchen Einfluss die Tätigkeit in einer geschlechtsspezifischen Berufsdomäne (z. B. in einer Männer oder Frauendomäne) auf die Wahrnehmung und das Erleben erwerbstätiger Männer und Frauen ausübt. Mittelpunkt der Untersuchung waren Erwerbstätige, die in einer Berufsdomäne tätig sind, die nicht mit ihrer Geschlechtsrolle übereinstimmt. [less ▲]

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See detailLe droit de l’Union européenne et les Constitutions nationales : primauté ou conciliation ?
Neframi, Eleftheria UL

in Revue de droit comparé, Institut japonais de droit comparé (2005), 2

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See detailRhombic embeddings of planar quad-graphs
Kenyon, Richard; Schlenker, Jean-Marc UL

in Trans. Amer. Math. Soc. (2005), 357(9), 3443--3458

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See detailPreferences and the Dynamic Representative Consumer
Koulovatianos, Christos UL

Report (2005)

This paper provides families of time-separable, twice continuously differentiable, and strictly concave utility functions of a group of consumers that are both suffcient and necessary in order to have ... [more ▼]

This paper provides families of time-separable, twice continuously differentiable, and strictly concave utility functions of a group of consumers that are both suffcient and necessary in order to have linear aggregation in a single-commodity-type deterministic dynamic environment, in the presence of consumer wealth-, labor-productivity, and preference heterogeneity, for alternative settings where the rates of time preference can be the same or different across consumers. The employed concept of linear aggregation pertains the existence of a representative consumer with a time-separable utility function. It is proved that when the rates of time preference are choice-independent and heterogeneous across consumers, a representative consumer exists if, and only if, the momentary utility functions of all consumers are exponential. Results are also provided for, (i) common across consumers choice-independent rates of time preference, and, (ii) heterogeneous choice-dependent rates of time preference, and compared with previously identified sufficient conditions for aggregation in the existing literature. [less ▲]

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See detailHigh-accuracy measurement of the spin-dependent neutron scattering length of the deuteron
van den Brandt, B.; Hautle, P.; Kohlbrecher, J. et al

in Proceedings of the 16th International Spin Physics Symposium and Workshop on Polarized Electron Sources and Polarimeters (2005)

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See detailAktionärslegitimation und Satzungsfreiheit - Überlegungen zu § 123 AktG idF des UMAG
Zetzsche, Dirk Andreas UL; Simon, S.

in NZG. Neue Zeitschrift für Gesellschaftsrecht (2005)

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See detailPioglitazone reverses down-regulation of cardiac PPARgamma expression in Zucker diabetic fatty rats.
Pelzer, Theo; Jazbutyte, Virginija; Arias-Loza, Paula Anahi et al

in Biochemical and biophysical research communications (2005), 329(2), 726-32

Peroxisome proliferator-activated receptor-gamma (PPARgamma) plays a critical role in peripheral glucose homeostasis and energy metabolism, and inhibits cardiac hypertrophy in non-diabetic animal models ... [more ▼]

Peroxisome proliferator-activated receptor-gamma (PPARgamma) plays a critical role in peripheral glucose homeostasis and energy metabolism, and inhibits cardiac hypertrophy in non-diabetic animal models. The functional role of PPARgamma in the diabetic heart, however, is not fully understood. Therefore, we analyzed cardiac gene expression, metabolic control, and cardiac glucose uptake in male Zucker diabetic fatty rats (ZDF fa/fa) and lean ZDF rats (+/+) treated with the high affinity PPARgamma agonist pioglitazone or placebo from 12 to 24 weeks of age. Hyperglycemia, hyperinsulinemia, and hypertriglyceridemia as well as lower cardiac PPARgamma, glucose transporter-4 and alpha-myosin heavy chain expression levels were detected in diabetic ZDF rats compared to lean animals. Pioglitazone increased body weight and improved metabolic control, cardiac PPARgamma, glut-4, and alpha-MHC expression levels in diabetic ZDF rats. Cardiac [(18)F]fluorodeoxyglucose uptake was not detectable by micro-PET studies in untreated and pioglitazone treated ZDF fa/fa rats but was observed after administration of insulin to pioglitazone treated ZDF fa/fa rats. PPARgamma agonists favorably affect cardiac gene expression in type-2 diabetic rats via activation and up-regulation of cardiac PPARgamma expression whereas improvement of impaired cardiac glucose uptake in advanced type-2 diabetes requires co-administration of insulin. [less ▲]

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See detailCandidate metabolic network states in human mitochondria. Impact of diabetes, ischemia, and diet.
Thiele, Ines UL; Price, Nathan D.; Vo, Thuy D. et al

in Journal of Biological Chemistry (2005), 280(12), 11683-95

The human mitochondrial metabolic network was recently reconstructed based on proteomic and biochemical data. Linear programming and uniform random sampling were applied herein to identify candidate ... [more ▼]

The human mitochondrial metabolic network was recently reconstructed based on proteomic and biochemical data. Linear programming and uniform random sampling were applied herein to identify candidate steady states of the metabolic network that were consistent with the imposed physico-chemical constraints and available experimental data. The activity of the mitochondrion was studied under four metabolic conditions: normal physiologic, diabetic, ischemic, and dietetic. Pairwise correlations between steady-state reaction fluxes were calculated in each condition to evaluate the dependence among the reactions in the network. Applying constraints on exchange fluxes resulted in predictions for intracellular fluxes that agreed with experimental data. Analyses of the steady-state flux distributions showed that the experimentally observed reduced activity of pyruvate dehydrogenase in vivo could be a result of stoichiometric constraints and therefore would not necessarily require enzymatic inhibition. The observed changes in the energy metabolism of the mitochondrion under diabetic conditions were used to evaluate the impact of previously suggested treatments. The results showed that neither normalized glucose uptake nor decreased ketone body uptake have a positive effect on the mitochondrial energy metabolism or network flexibility. Taken together, this study showed that sampling of the steady-state flux space is a powerful method to investigate network properties under different conditions and provides a basis for in silico evaluations of effects of potential disease treatments. [less ▲]

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See detailThe sarcolemmal calcium pump inhibits the calcineurin/nuclear factor of activated T-cell pathway via interaction with the calcineurin A catalytic subunit.
Buch, Mamta H.; Pickard, Adam; Rodriguez, Antonio et al

in The Journal of biological chemistry (2005), 280(33), 29479-87

The calcineurin/nuclear factor of activated T-cell (NFAT) pathway represents a crucial transducer of cellular function. There is increasing evidence placing the sarcolemmal calcium pump, or plasma ... [more ▼]

The calcineurin/nuclear factor of activated T-cell (NFAT) pathway represents a crucial transducer of cellular function. There is increasing evidence placing the sarcolemmal calcium pump, or plasma membrane calcium/calmodulin ATPase pump (PMCA), as a potential modulator of signal transduction pathways. We demonstrate a novel interaction between PMCA and the calcium/calmodulin-dependent phosphatase, calcineurin, in mammalian cells. The interaction domains were located to the catalytic domain of PMCA4b and the catalytic domain of the calcineurin A subunit. Endogenous calcineurin activity, assessed by measuring the transcriptional activity of its best characterized substrate, NFAT, was significantly inhibited by 60% in the presence of ectopic PMCA4b. This inhibition was notably reversed by the co-expression of the PMCA4b interaction domain, demonstrating the functional significance of this interaction. PMCA4b was, however, unable to confer its inhibitory effect in the presence of a calcium/calmodulin-independent constitutively active mutant calcineurin A suggesting a calcium/calmodulin-dependent mechanism. The modulatory function of PMCA4b is further supported by the observation that endogenous calcineurin moves from the cytoplasm to the plasma membrane when PMCA4b is overexpressed. We suggest recruitment by PMCA4b of calcineurin to a low calcium environment as a possible explanation for these findings. In summary, our results offer strong evidence for a novel functional interaction between PMCA and calcineurin, suggesting a role for PMCA as a negative modulator of calcineurin-mediated signaling pathways in mammalian cells. This study reinforces the emerging role of PMCA as a molecular organizer and regulator of signaling transduction pathways. [less ▲]

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See detailTargeted proteolysis sustains calcineurin activation.
Burkard, Natalie; Becher, Jan; Heindl, Cornelia et al

in Circulation (2005), 111(8), 1045-53

BACKGROUND: Calcineurin (CnA) is important in the regulation of myocardial hypertrophy. We demonstrated that targeted proteolysis of the CnA autoinhibitory domain under pathological myocardial workload ... [more ▼]

BACKGROUND: Calcineurin (CnA) is important in the regulation of myocardial hypertrophy. We demonstrated that targeted proteolysis of the CnA autoinhibitory domain under pathological myocardial workload leads to increased CnA activity in human myocardium. Here, we investigated the proteolytic mechanism leading to activation of CnA. METHODS AND RESULTS: In patients with diseased myocardium, we found strong nuclear translocation of CnA. In contrast, in normal human myocardium, there was a cytosolic distribution of CnA. Stimulation of rat cardiomyocytes with angiotensin (Ang) II increased calpain activity significantly (433+/-11%; P<0.01; n=6) and caused proteolysis of the autoinhibitory domain of CnA. Inhibition of calpain by a membrane-permeable calpain inhibitor prevented proteolysis. We identified the cleavage site of calpain in the human CnA sequence at amino acid 424. CnA activity was increased after Ang II stimulation (310+/-29%; P<0.01; n=6) and remained high after removal of Ang II (214+/-17%; P<0.01; n=6). Addition of a calpain inhibitor to the medium decreased CnA activity (110+/-19%; P=NS; n=6) after removal of Ang II. Ang II stimulation of cardiomyocytes also translocated CnA into the nucleus as demonstrated by immunohistochemical staining and transfection assays with GFP-tagged CnA. Calpain inhibition and therefore suppression of calpain-mediated proteolysis of CnA enabled CnA exit from the nucleus. CONCLUSIONS: Ang II stimulation of cardiomyocytes increased calpain activity, leading to proteolysis of the autoinhibitory domain of CnA. This causes an increase in CnA activity and results in nuclear translocation of CnA. Loss of the autoinhibitory domain renders CnA constitutively nuclear and active, even after removal of the hypertrophic stimulus. [less ▲]

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See detailÜberlegungen zum Thema „Bildungsstandards“ in fremd- und zweitsprachlichen Kontexten.
Hu, Adelheid UL

in Bausch, K.-R.; Burwitz-Meltzer, E.; Königs, F. (Eds.) et al Dokumentation der Frühjahrskonferenz zur Erforschung des Fremdsprachenlernens Februar 2005 (2005)

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See detail„Ich glaub’, sie wollen uns mehr integrieren...“ Ausgewählte Ergebnisse einer qualitativ-empirischen Studie zu schulischem Sprachenunterricht und migrationsbedingter Mehrsprachigkeit.
Hu, Adelheid UL

in Wolff, A.; Ostermann, T. (Eds.) Integration durch Sprache. Dokumentation der 31. Jahrestagung DaF 2003 (2005)

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See detailKulturwissenschaft(en) und Fremdsprachenforschung
Hu, Adelheid UL

in Schumann, A. (Ed.) Kulturwissenschaften und Fremdsprachendidaktik im Dialog. Perspektiven eines interkulturellen Französischunterricht. (2005)

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See detailStudies in Philosophy and Education Volume 24
Biesta, Gert UL

in Studies in Philosophy & Education (2005), 24

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See detailForever young? Subjective age and life satisfaction in old age
Ferring, Dieter UL; Petit, C.

in Abstracts of the 9th European Congress of Psychology, Granada (Spain), 3.-7. July 2005. (2005)

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See detailMehrsprachigkeit und Identität. Überlegungen für ein aufgabenorientiertes sprachübergreifendes Projekt im Französisch- und Spanischunterricht der Sekundarstufe I
Hu, Adelheid UL

in Müller-Hartmann, A.; Schocker-von-Dittfurth, M. (Eds.) Aufgabenorientierung im Fremdsprachenunterricht. Tasked based language learning and teaching. Festschrift zum 60. Geburtstag von Michael Legutke. (2005)

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See detailTwenty Years of Bialowieza: A Mathematical Anthology Aspects of differential geometric methods in physics
Ali, Syed Twareque UL; Emch, Gerald; Odzijewicz, Anatol et al

Book published by World Scientific (2005)

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