References of "2005"
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See detailOn track for a 2-hour marathon
Stankiewicz, Jacek UL

in South African Journal of Science (2005), 101(9-10), 397-398

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See detailEducation and Pragmatism
Tröhler, Daniel UL; Oelkers, Jürgen

Book published by Sense Publisher (2005)

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See detailLife in Language Studies in Honour of Wolfgang Kühlwein
Weber, Jean-Jacques UL; Horner, Kristine; Schuth, Andreas

Book published by Wissenschaftlicher Verlag Trier (2005)

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See detailCompétitivité de l’économie luxembourgeoise 2004
Bourgain, Arnaud UL; Bley, Laurent; Pieretti, Patrice UL et al

Report (2005)

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See detailMolecular dynamics simulation of truncated bovine adrenodoxin
Shakya, S. K.; Gu, Wei UL; Helms, V.

in Biopolymers (2005), 78(1), 9-20

The 128 amino acid long soluble protein adrenodoxin (Adx) is a typical member of the ferredoxin protein family that are electron carrier proteins with an iron-sulfur cofactor. Adx carries electrons from ... [more ▼]

The 128 amino acid long soluble protein adrenodoxin (Adx) is a typical member of the ferredoxin protein family that are electron carrier proteins with an iron-sulfur cofactor. Adx carries electrons from adrenodoxin reductase (AdR) to cytochrome P450s. Its binding modes to these proteins were previously characterized by site-directed mutagenesis, by X-ray crystallography for the complex Adx:AdR, and by NMR. However, no clear evidence has been provided for the driving force that promotes Adx detachment from AdR upon reduction. Here, we characterized the conformational dynamics of unbound Adx in the oxidized and reduced forms using 2-20 ns long molecular dynamics simulations. The most noticeable difference between both forms is the enhanced flexibility of the loop (47-51) surrounding the iron-sulfur cluster in the reduced form. Together with several structural displacements at the binding interface, this increased flexibility may be the key factor promoting unbinding of reduced Adx from AdR. This points to an intrinsic property of reduced Adx that drives dissociation. (c) 2005 Wiley Periodicals, Inc. [less ▲]

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See detailHeuristiek voor het Historisch-Pedagogisch Onderzoek en de Waarde van het Internet. Over de Concrete Zoektocht naar het Pedagogisch Verleden
Henkens, Bregt; Catteeuw, Karl; Thyssen, Geert UL

in Depaepe, Mark; Simon, Frank; Van Gorp, Angelo (Eds.) Paradoxen van Pedagogisering. Handboek Pedagogische Historiografie (2005)

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See detail«Editorial»
Roelens, Nathalie UL

in Voir (2005)

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See detailVon der Fremdenherberge zum Seniorenheim: Funktionswandel in mittelalterlichen Hospitälern an ausgewählten Beispielen aus dem Maas-Mosel-Rhein-Raum
Pauly, Michel UL

in Matheus, Michael (Ed.) Funktions- und Strukturwandel spätmittelalterlicher Hospitäler im europäischen Vergleich (2005)

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See detailLa regulation américaine des agences de notation
Conac, Pierre-Henri UL

in Risques : les cahiers de l'assurance (2005), (61), 55-55

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See detailAre solvation free energies of homogeneous helical peptides additive?
Staritzbichler, R.; Gu, Wei UL; Helms, V.

in Journal of Physical Chemistry B (2005), 109(40), 19000-19007

We investigated the additivity of the solvation free energy of amino acids in homogeneous helices of different length in water and in chloroform. Solvation free energies were computed by ... [more ▼]

We investigated the additivity of the solvation free energy of amino acids in homogeneous helices of different length in water and in chloroform. Solvation free energies were computed by multiconfiguration thermodynamic integration involving extended molecular dynamics simulations and by applying the generalized-born surface area solvation model to static helix geometries. The investigation focused on homogeneous peptides composed of uncharged amino acids, where the backbone atoms are kept fixed in an ideal helical conformation. We found nonlinearity especially for short peptides, which does not allow a simple treatment of the interaction of amino acids with their surroundings. For homogeneous peptides longer than five residues, the results from both methods are in quite good agreement and solvation energies are to a good extent additive. [less ▲]

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See detailCyclophilin a binds to linear peptide motifs containing a consensus that is present in many human proteins
Piotukh, K.; Gu, Wei UL; Kofler, M. et al

in Journal of Biological Chemistry (2005), 280(25), 23668-23674

Cyclophilin A ( CypA) is a peptidyl-prolyl cis/trans-isomerase that is involved in multiple signaling events of eukaryotic cells. It might either act as a catalyst for prolyl bond isomerization, or it can ... [more ▼]

Cyclophilin A ( CypA) is a peptidyl-prolyl cis/trans-isomerase that is involved in multiple signaling events of eukaryotic cells. It might either act as a catalyst for prolyl bond isomerization, or it can form stoichiometric complexes with target proteins. We have investigated the linear sequence recognition code for CypA by phage display and found the consensus motif FGPXLp to be selected after five rounds of panning. The peptide FGP-DLPAGD showed inhibition of the isomerase reaction and NMR chemical shift mapping experiments highlight the CypA interaction epitope. Ligand docking suggests that the peptide was able to bind to CypA in the cis- and trans-conformation. Protein Data Bank searches reveal that many human proteins contain the consensus motif, and several of these protein motifs are shown to interact with CypA in vitro. These sequences represent putative target sites for binding of CypA to intracellular proteins. [less ▲]

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See detailAlternative binding modes of proline-rich peptides binding to the GYF domain
Gu, Wei UL; Kofler, M.; Antes, I. et al

in Biochemistry (2005), 44(17), 6404-6415

Recognition of proline-rich sequences plays an important role for the assembly of multiprotein complexes during the course of eukaryotic signal transduction and is mediated by a set of protein folds that ... [more ▼]

Recognition of proline-rich sequences plays an important role for the assembly of multiprotein complexes during the course of eukaryotic signal transduction and is mediated by a set of protein folds that share characteristic features. The GYF (glycine-tyrosine-phenylalanine) domain is known as a member of the superfamily of recognition domains for proline-rich sequences. Recent studies on the complexation of the CD2BP2-GYF domain with CD2 peptides showed that the peptide adopts an extended conformation and forms a polyproline type-II helix involving residues Pro4-Pro7 [Freund et al. (2002) EMBO J. 21, 5985-5995]. R/K/GxxPPGxR/K is the key signature for the peptides that bind to the GYF domain [Kofler et at. (2004) J. Biol. Chem. 279, 28292-28297]. In our combined theoretical and experimental study, we show that the peptides adopt a polyproline 11 helical conformation in the unbound form as well as in the complex. From molecular dynamics simulations, we identify a novel binding mode for the G8W mutant and the wild-type peptide (shifted by one proline in register). In contrast, the conformation of the peptide mutant H9M remains close to the experimentally derived wild-type GYF-peptide complex. Possible functional implications of this altered conformation of the bound ligand are discussed in the light of our experimental and theoretical results. [less ▲]

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See detailDynamical binding of proline-rich peptides to their recognition domains
Gu, Wei UL; Helms, V.

in Biochimica et Biophysica Acta-Proteins and Proteomics (2005), 1754(1-2), 232-238

Recognition of proline-rich sequences plays an important role for the assembly of multi-protein complexes during the course of eukaryotic signal transduction and is mediated by a set of protein folds that ... [more ▼]

Recognition of proline-rich sequences plays an important role for the assembly of multi-protein complexes during the course of eukaryotic signal transduction and is mediated by a set of protein folds that share characteristic features. For many complex systems containing proline-rich sequences, multiple binding modes have been found by theoretical and/or experimental studies. In this review, we discuss the different binding modes as well as the correlated dynamics of the peptides and their recognition domains, and some implications to their biological functions. Further-more, we give an outlook of the systems in the context of systems biology. (c) 2005 Elsevier B.V. All rights reserved. [less ▲]

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See detailLangue as Homeland: The Genevan of Reception of Pragmatism
Tröhler, Daniel UL

in Popkewitz, Thomas (Ed.) Inventing the Modern Self and John Dewey. Modernities and the Travelling of Pragmatism in Education (2005)

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See detailEthique et humanitaire. Mise en œuvre des pratiques de consultation et de participation
Baumann, Michèle UL; Vié Le Sage, F.

in Pédiatre (Le) (2005), (211), 2-5

Au cours des dernières décennies, l’aide humanitaire a pris un essor considérable. En même temps, elle s’est trouvée confrontée à un nombre croissant de critiques dont la plus significative est celle d ... [more ▼]

Au cours des dernières décennies, l’aide humanitaire a pris un essor considérable. En même temps, elle s’est trouvée confrontée à un nombre croissant de critiques dont la plus significative est celle d'être perçue comme un système défini et imposé par l’occident, fonctionnant sur un mode « descendant » et ayant de ce fait, une capacité d’écoute sélective. Le rôle des populations touchées dans leur propre survie est l'un des défis les plus complexes auquel le monde des acteurs humanitaires doit faire face. En particulier la prise en compte des points de vue, des attentes, des besoins exprimés, des responsabilités, des compétences des populations concernées, durant tout le cycle de la gestion du projet, est une condition indispensable à l'amélioration de la réponse humanitaire vue en tant que processus de réappropriation de la part des populations de leur pouvoir d'agir sur leur vie. A cet égard, l'idée selon laquelle une implication active du public est une condition nécessaire pour assurer le caractère éthique de toute délibération et garantir l’acceptation des interventions par les populations est aujourd'hui reconnue, mais est-elle suffisante, est elle toujours possible ? [less ▲]

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See detailVernieuwing in de Franjes? Openluchtscholen en de Traditie van Pedagogisering
Depaepe, Marc; Simon, Frank; Thyssen, Geert UL et al

in Paradoxen van Pedagogisering. Handboek Pedagogische Historiografie (2005)

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See detailPrivate or self-regulation? A comparative study of forest certification choices in Canada, the United States and Germany
Cashore, Benjamin; Van Kooten, G. Cornelis; Vertinsky, Ilan et al

in Forest Policy and Economics (2005), 7(1), 53-69

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See detailThe subsystems approach to genome annotation and its use in the project to annotate 1000 genomes.
Overbeek, Ross; Begley, Tadhg; Butler, Ralph M. et al

in Nucleic Acids Research (2005), 33(17), 5691-702

The release of the 1000th complete microbial genome will occur in the next two to three years. In anticipation of this milestone, the Fellowship for Interpretation of Genomes (FIG) launched the Project to ... [more ▼]

The release of the 1000th complete microbial genome will occur in the next two to three years. In anticipation of this milestone, the Fellowship for Interpretation of Genomes (FIG) launched the Project to Annotate 1000 Genomes. The project is built around the principle that the key to improved accuracy in high-throughput annotation technology is to have experts annotate single subsystems over the complete collection of genomes, rather than having an annotation expert attempt to annotate all of the genes in a single genome. Using the subsystems approach, all of the genes implementing the subsystem are analyzed by an expert in that subsystem. An annotation environment was created where populated subsystems are curated and projected to new genomes. A portable notion of a populated subsystem was defined, and tools developed for exchanging and curating these objects. Tools were also developed to resolve conflicts between populated subsystems. The SEED is the first annotation environment that supports this model of annotation. Here, we describe the subsystem approach, and offer the first release of our growing library of populated subsystems. The initial release of data includes 180 177 distinct proteins with 2133 distinct functional roles. This data comes from 173 subsystems and 383 different organisms. [less ▲]

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See detailDer Einfluss von Expertise auf den Prozess der schulischen Leistungsbeurteilung
Krolak-Schwerdt, Sabine UL; Rummer, Ralf

in Zeitschrift für Entwicklungspsychologie und Padagogische Psychologie (2005), 37

Two experiments investigated the effects of information processing goals on the recall of information about pupils and on achievement judgments. In Experiment 1 teachers (experts) were presented with case ... [more ▼]

Two experiments investigated the effects of information processing goals on the recall of information about pupils and on achievement judgments. In Experiment 1 teachers (experts) were presented with case reports about pupils. The reports were either read under the instruction (a) to form an impression of the personality of the described pupils or (b) to predict their future development. Afterwards subjects had to recall the case reports and to rate the academic achievement of the described pupils. Experiment 2 was a replication with university freshmen (laymen) as subjects. Depending on their processing goal, experts switched their processing of pupil information from top-down strategies involving the activation of prototypical categories about pupil personalities to bottom-up processing which consists of integrating the features of the individual case. Thus, processing goals appear as moderators in teachers’ judgments. [less ▲]

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