La recherche sur la Première Guerre mondiale : un champ disciplinaire en plein développement

in Amara, Michael; Jaumain, Serge; Majerus, Benoît (Eds.) et al Une ‘guerre totale’? La Belgique dans la Première Guerre mondiale. Nouvelles tendances de la recherche historique (2005)

The representation of immigrant students within the classical-humanist ethos of the Luxembourgish school-system

in Life in Language (2005)

Cyclophilin a binds to linear peptide motifs containing a consensus that is present in many human proteins

in Journal of Biological Chemistry (2005), 280(25), 23668-23674

Cyclophilin A ( CypA) is a peptidyl-prolyl cis/trans-isomerase that is involved in multiple signaling events of eukaryotic cells. It might either act as a catalyst for prolyl bond isomerization, or it can ... [more ▼]

Cyclophilin A ( CypA) is a peptidyl-prolyl cis/trans-isomerase that is involved in multiple signaling events of eukaryotic cells. It might either act as a catalyst for prolyl bond isomerization, or it can form stoichiometric complexes with target proteins. We have investigated the linear sequence recognition code for CypA by phage display and found the consensus motif FGPXLp to be selected after five rounds of panning. The peptide FGP-DLPAGD showed inhibition of the isomerase reaction and NMR chemical shift mapping experiments highlight the CypA interaction epitope. Ligand docking suggests that the peptide was able to bind to CypA in the cis- and trans-conformation. Protein Data Bank searches reveal that many human proteins contain the consensus motif, and several of these protein motifs are shown to interact with CypA in vitro. These sequences represent putative target sites for binding of CypA to intracellular proteins. [less ▲]

Dynamical binding of proline-rich peptides to their recognition domains

in Biochimica et Biophysica Acta-Proteins and Proteomics (2005), 1754(1-2), 232-238

Recognition of proline-rich sequences plays an important role for the assembly of multi-protein complexes during the course of eukaryotic signal transduction and is mediated by a set of protein folds that ... [more ▼]

Recognition of proline-rich sequences plays an important role for the assembly of multi-protein complexes during the course of eukaryotic signal transduction and is mediated by a set of protein folds that share characteristic features. For many complex systems containing proline-rich sequences, multiple binding modes have been found by theoretical and/or experimental studies. In this review, we discuss the different binding modes as well as the correlated dynamics of the peptides and their recognition domains, and some implications to their biological functions. Further-more, we give an outlook of the systems in the context of systems biology. (c) 2005 Elsevier B.V. All rights reserved. [less ▲]

Ethique et humanitaire. Mise en œuvre des pratiques de consultation et de participation

in Pédiatre (Le) (2005), (211), 2-5

Au cours des dernières décennies, l’aide humanitaire a pris un essor considérable. En même temps, elle s’est trouvée confrontée à un nombre croissant de critiques dont la plus significative est celle d ... [more ▼]

Au cours des dernières décennies, l’aide humanitaire a pris un essor considérable. En même temps, elle s’est trouvée confrontée à un nombre croissant de critiques dont la plus significative est celle d'être perçue comme un système défini et imposé par l’occident, fonctionnant sur un mode « descendant » et ayant de ce fait, une capacité d’écoute sélective. Le rôle des populations touchées dans leur propre survie est l'un des défis les plus complexes auquel le monde des acteurs humanitaires doit faire face. En particulier la prise en compte des points de vue, des attentes, des besoins exprimés, des responsabilités, des compétences des populations concernées, durant tout le cycle de la gestion du projet, est une condition indispensable à l'amélioration de la réponse humanitaire vue en tant que processus de réappropriation de la part des populations de leur pouvoir d'agir sur leur vie. A cet égard, l'idée selon laquelle une implication active du public est une condition nécessaire pour assurer le caractère éthique de toute délibération et garantir l’acceptation des interventions par les populations est aujourd'hui reconnue, mais est-elle suffisante, est elle toujours possible ? [less ▲]

Private or self-regulation? A comparative study of forest certification choices in Canada, the United States and Germany

in Forest Policy and Economics (2005), 7(1), 53-69

Expanded metabolic reconstruction of Helicobacter pylori (iIT341 GSM/GPR): an in silico genome-scale characterization of single- and double-deletion mutants.

in Journal of Bacteriology (2005), 187(16), 5818-30

Helicobacter pylori is a human gastric pathogen infecting almost half of the world population. Herein, we present an updated version of the metabolic reconstruction of H. pylori strain 26695 based on the ... [more ▼]

Helicobacter pylori is a human gastric pathogen infecting almost half of the world population. Herein, we present an updated version of the metabolic reconstruction of H. pylori strain 26695 based on the revised genome annotation and new experimental data. This reconstruction, iIT341 GSM/GPR, represents a detailed review of the current literature about H. pylori as it integrates biochemical and genomic data in a comprehensive framework. In total, it accounts for 341 metabolic genes, 476 intracellular reactions, 78 exchange reactions, and 485 metabolites. Novel features of iIT341 GSM/GPR include (i) gene-protein-reaction associations, (ii) elementally and charge-balanced reactions, (iii) more accurate descriptions of isoprenoid and lipopolysaccharide metabolism, and (iv) quantitative assessments of the supporting data for each reaction. This metabolic reconstruction was used to carry out in silico deletion studies to identify essential and conditionally essential genes in H. pylori. A total of 128 essential and 75 conditionally essential metabolic genes were identified. Predicted growth phenotypes of single knockouts were validated using published experimental data. In addition, in silico double-deletion studies identified a total of 47 synthetic lethal mutants involving 67 different metabolic genes in rich medium. [less ▲]

Die Adresse des Fake : Über das Wahre im Falschen

in Barth, Thomas; Betzer, Christian; Eder, Jens (Eds.) Mediale Spielräume : Erfundene Welten, Gestaltete Bilder (2005)

Analyse des questionnaires-élèves de l'enquête PISA 2000 au Luxembourg

Report (2005)

‘Le goût des mots et l’appétit des sciences’ : quelques remarques pragmatiques et stylistiques sur deux magazines de vulgarisation scientifique

in Sciences et écritures (2005)