Résultats de la première passation du questionnaire informatisé auprès d'une cohorte de demandeurs d'emploi au Luxembourg, Working paper n° 3.

Report (2005)

Wirtschaftsverkehr in Stadt und Umland - Ein neues Tätigkeitsfeld für "integrierte Planung"

in Verkehrszeichen : für Mobilität und Umwelt (2005), (1), 12-16

Modern city, social justice, and education Early Pragmatism as exemplified by Jane Addams

in Tröhler, Daniel; Oelkers, Jürgen (Eds.) Education and Pragmatism (2005)

Increased mortality and aggravation of heart failure in estrogen receptor-beta knockout mice after myocardial infarction.

in Circulation (2005), 111(12), 1492-8

BACKGROUND: Lower mortality rates among women with chronic heart failure than among men may depend in part on the action of female sex hormones, especially estrogens. The biological effects of estrogens ... [more ▼]

BACKGROUND: Lower mortality rates among women with chronic heart failure than among men may depend in part on the action of female sex hormones, especially estrogens. The biological effects of estrogens are mediated by 2 distinct estrogen receptor (ER) subtypes (ERalpha and ERbeta). The present study was undertaken to determine the role of ERbeta in the development of chronic heart failure after experimental myocardial infarction (MI). METHODS AND RESULTS: Female ERbeta null mice (BERKO(Chapel Hill)) and wild-type littermates (WT) were ovariectomized, given 17beta-estradiol, and subjected to chronic anterior MI (MI; BERKO n=31, WT n=30) or sham operation (sham; BERKO n=14, WT n=14). At 8 weeks after MI, both genotypes revealed left ventricular remodeling and impaired contractile function at similar average infarct size (BERKO-MI 32.9+/-5% versus WT-MI 33.0+/-4%); however, BERKO mice showed increased mortality (BERKO-MI 42% versus WT-MI 23%), increased body weight and fluid retention (P<0.01), higher ventricular pro-ANP expression (BERKO-MI 27.9-fold versus sham, WT-MI 5.2-fold versus sham; BERKO-MI versus WT-MI P<0.001), higher atrial natriuretic peptide serum levels, and increased phospholamban expression (P<0.05) compared with WT mice. CONCLUSIONS: Systemic deletion of ERbeta in female mice increases mortality, aggravates clinical and biochemical markers of heart failure, and contributes to impaired expression of Ca(2+)-handling proteins in chronic heart failure after MI. Further studies are required to delineate the relative importance of cardiac and vascular effects of ERbeta and the role of ERalpha in the development of heart failure. [less ▲]

Zur Dynamik der regionalen Variation im Luxemburgischen

in Institut Grand-Ducal, Section de Linguistique, d'Ethnologie et d'Onomastique; Centre National de Littérature (Eds.) Letzebuergesch. Entwicklungstendenzen und Forschungsperspektiven einer jungen Sprache. Beiträge zum Workshop Lëtzebuergesch, November 2001 (2005)

Dramatischer Bilderdienst. "Zur Trilogie des Wiedersehens" von Botho Strauß

in Heimböckel, Dieter; Werlein, Uwe (Eds.) Der Bildhunger der Literatur. Festschrift für Gunter E. Grimm (2005)

1alpha,25-Dihydroxyvitamin D3 is a potent suppressor of interferon gamma-mediated macrophage activation.

in Blood (2005), 106(13), 4351-8

1alpha,25-Dihydroxyvitamin D3 (1alpha,25(OH)2D3), the activated vitamin D3 hormone, is a key regulator of calcium homeostasis and thereby indispensable for bone metabolism. In addition, 1alpha,25(OH)2D3 ... [more ▼]

1alpha,25-Dihydroxyvitamin D3 (1alpha,25(OH)2D3), the activated vitamin D3 hormone, is a key regulator of calcium homeostasis and thereby indispensable for bone metabolism. In addition, 1alpha,25(OH)2D3 is known to mediate predominantly immunosuppressive responses in vitro and in vivo. It has been demonstrated that macrophages can produce 1alpha,25(OH)2D3 on activation with interferon gamma (IFN-gamma), although little is understood about the biologic significance of this response. We show here that 1alpha,25(OH)2D3 can selectively suppress key effector functions of IFN-gamma-activated macrophages. Among these are the suppression of listericidal activity, the inhibition of phagocyte oxidase-mediated oxidative burst, and the suppression of important IFN-gamma-induced genes, including Ccl5, Cxcl10, Cxcl9, Irf2, Fcgr1, Fcgr3, and Tlr2. The deactivation of IFN-gamma-stimulated macrophages is dependent on a functional vitamin D receptor and 1alpha,25(OH)2D3 acts specifically on IFN-gamma-activated macrophages, whereas the steroid has no effects on resting macrophages. Therefore, the 1alpha,25(OH)2D3-mediated suppression of macrophage functions is distinct from previously described macrophage deactivation mechanisms. In conclusion, our data indicate that the production of 1alpha,25(OH)2D3 by IFN-gamma-stimulated macrophages might be an important negative feedback mechanism to control innate and inflammatory responses of activated macrophages. [less ▲]

La recherche sur la Première Guerre mondiale : un champ disciplinaire en plein développement

in Amara, Michael; Jaumain, Serge; Majerus, Benoît (Eds.) et al Une ‘guerre totale’? La Belgique dans la Première Guerre mondiale. Nouvelles tendances de la recherche historique (2005)

Compétitivité de l’économie luxembourgeoise 2004

Report (2005)

CAMPUS: a generic framework for Computer Assisted Mathematical Problem Understanding and Solving

in Proceedings of the world conference on educational media, hypermedia and telecommunications 2005 (2005)