![]() Martin, Romain ![]() ![]() in Actes du 18e colloque de l’ADMEE-Europe Reims 2005: Comment évaluer? Outils, dispositifs, acteurs. (2005) Detailed reference viewed: 91 (1 UL)![]() ![]() Peccati, Giovanni ![]() in Séminaire de Probabilités XXXVIII (2005) Detailed reference viewed: 168 (13 UL)![]() ![]() Vögele, Claus ![]() in Munsch, S.; Beglinger, P. (Eds.) Obesity and Binge Eating Disorder (2005) Detailed reference viewed: 105 (1 UL)![]() ![]() Priem, Karin ![]() in Vierteljahresschrift für wissenschaftliche Pädagogik (2005), 81 Detailed reference viewed: 293 (0 UL)![]() ![]() Bréchard, Sabrina ![]() ![]() ![]() in Cell Calcium (2005), 37(6), 531-40 In response to a variety of stimuli, neutrophils release large amount of reactive oxygen species (ROS) generated by NADPH oxidase. This process known as the respiratory burst is dependent on cytosolic ... [more ▼] In response to a variety of stimuli, neutrophils release large amount of reactive oxygen species (ROS) generated by NADPH oxidase. This process known as the respiratory burst is dependent on cytosolic free calcium concentration ([Ca(2+)](i)). Proinflammatory cytokines such as interleukin-8 (IL-8) may modulate ROS generation through a priming phenomenon. The aim of this study was to determine the effect of human IL-8 on ROS production in neutrophil-like dimethylsulfoxide-differentiated HL-60 cells (not equalHL-60 cells) and further to examine the role of Ca(2+) mobilization during the priming. IL-8 at 10 nM induced no ROS production but a [Ca(2+)](i) rise (254 +/- 36 nM). IL-8 induced a strongly enhanced (2 fold) ROS release during stimulation with 1 microM of N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLF). This potentiation of ROS production is dependent of extracellular Ca(2+) (17.0+/-4.5 arbitrary units (A.U.) in the absence of Ca(2+) versus 56.6 +/- 3.9 A.U. in the presence of 1.25 mM of Ca(2+)). Also, IL-8 enhanced fMLF-stimulated increase in [Ca(2+)](i) (375 +/- 35 versus 245 +/- 21 nM, 0.1 microM of fMLF). IL-8 had no effect on not equalHL-60 cells in response to 1 microM of thapsigargin (472 +/- 66 versus 470 +/- 60 nM). In conclusion, Ca(2+) influx is necessary for a full induction of neutrophil priming by IL-8. [less ▲] Detailed reference viewed: 153 (2 UL)![]() ![]() Schulz, André ![]() in Psychophysiology (2005), 42(Supplement 1), 106-106 Detailed reference viewed: 57 (0 UL)![]() Vögele, Claus ![]() in Kerr; Moretti, M.; Weitkunat, R. (Eds.) ABC of Behaviour Change (2005) Detailed reference viewed: 58 (2 UL)![]() ![]() ; Peccati, Giovanni ![]() in Annals of Probability (2005), 33(1), 177--193 Detailed reference viewed: 156 (1 UL)![]() ![]() ; Vögele, Claus ![]() in Neudeck, P.; Wittchen, H.-U. (Eds.) Reader Konfrontationstherapie (2005) Detailed reference viewed: 79 (0 UL)![]() Ferring, Dieter ![]() in Abstracts of the 9th European Congress of Psychology, Granada (Spain), 3.-7. July 2005. (2005) Detailed reference viewed: 46 (0 UL)![]() ![]() Happold, Matthew ![]() in Leiden Journal of International Law (2005), 18 Detailed reference viewed: 162 (5 UL)![]() Prüm, André ![]() in Revue de Droit Bancaire et Financier (2005), (1), Detailed reference viewed: 64 (0 UL)![]() Willems, Helmut ![]() in Heitmeyer, Wilhelm; Imbusch, Peter (Eds.) Integrationspotenziale einer modernen Gesellschaft (2005) Detailed reference viewed: 143 (5 UL)![]() Martin, Romain ![]() ![]() in Proceedings of World Conference on Educational Multimedia, Hypermedia and Telecommunications (2005) Detailed reference viewed: 92 (0 UL)![]() ![]() Tröhler, Daniel ![]() in Zeitschrift für Pädagogik (2005), 51 Detailed reference viewed: 95 (0 UL)![]() ![]() Priem, Karin ![]() in Jahrbuch für Historische Bildungsforschung, 11 (2005) Detailed reference viewed: 55 (0 UL)![]() ![]() Tröhler, Daniel ![]() in Göhlich, Michael; Hopf, Caroline; Sausele, Ines (Eds.) Pädagogische Organisationsforschung (2005) Detailed reference viewed: 93 (0 UL)![]() ![]() Leprévost, Franck ![]() ![]() in Information Processing Letters (2005), 93 Detailed reference viewed: 153 (2 UL)![]() ![]() ; ; Schneider, Reinhard ![]() in Drug Discovery Today (2005), 10(21), 1475-1482 Every entirely sequenced genome reveals 100s to 1000s of protein sequences for which the only annotation available is 'hypothetical protein'. Thus, in the human genome and in the genomes of pathogenic ... [more ▼] Every entirely sequenced genome reveals 100s to 1000s of protein sequences for which the only annotation available is 'hypothetical protein'. Thus, in the human genome and in the genomes of pathogenic agents there could be 1000s of potential, unexplored drug targets. Computational prediction of protein function can play a role in studying these targets. We shall review the challenges, research approaches and recently developed tools in the field of computational function-prediction and we will discuss the ways these issues can change the process of drug discovery. [less ▲] Detailed reference viewed: 139 (0 UL)![]() ; Schneider, Reinhard ![]() in Bioscience Reports (2005), 25(1-2), 95-106 The field of proteomics is advancing rapidly as a result of powerful new technologies and proteomics experiments yield a vast and increasing amount of information. Data regarding protein occurrence ... [more ▼] The field of proteomics is advancing rapidly as a result of powerful new technologies and proteomics experiments yield a vast and increasing amount of information. Data regarding protein occurrence, abundance, identity, sequence, structure, properties, and interactions need to be stored. Currently, a common standard has not yet been established and open access to results is needed for further development of robust analysis algorithms. Databases for proteomics will evolve from pure storage into knowledge resources, providing a repository for information (meta-data) which is mainly not stored in simple flat files. This review will shed light on recent steps towards the generation of a common standard in proteomics data storage and integration, but is not meant to be a comprehensive overview of all available databases and tools in the proteomics community. [less ▲] Detailed reference viewed: 151 (0 UL) |
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