References of "2003"
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See detailGefühl und Begründung. Humes dreidimensionaler Überzeugungsbegriff
Heidemann, Dietmar UL

in Kritisches Jahrbuch der Philosophie (2003), 8

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See detailJVirGel: calculation of virtual two-dimensional protein gels
Hiller, Karsten UL; Schobert, Max; Hundertmark, Claudia et al

in Nucleic Acids Research (2003)

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See detailAutomatic methods for predicting functionally important residues.
del Sol Mesa, Antonio UL; Pazos, Florencio; Valencia, Alfonso

in Journal of molecular biology (2003), 326(4), 1289-302

Sequence analysis is often the first guide for the prediction of residues in a protein family that may have functional significance. A few methods have been proposed which use the division of protein ... [more ▼]

Sequence analysis is often the first guide for the prediction of residues in a protein family that may have functional significance. A few methods have been proposed which use the division of protein families into subfamilies in the search for those positions that could have some functional significance for the whole family, but at the same time which exhibit the specificity of each subfamily ("Tree-determinant residues"). However, there are still many unsolved questions like the best division of a protein family into subfamilies, or the accurate detection of sequence variation patterns characteristic of different subfamilies. Here we present a systematic study in a significant number of protein families, testing the statistical meaning of the Tree-determinant residues predicted by three different methods that represent the range of available approaches. The first method takes as a starting point a phylogenetic representation of a protein family and, following the principle of Relative Entropy from Information Theory, automatically searches for the optimal division of the family into subfamilies. The second method looks for positions whose mutational behavior is reminiscent of the mutational behavior of the full-length proteins, by directly comparing the corresponding distance matrices. The third method is an automation of the analysis of distribution of sequences and amino acid positions in the corresponding multidimensional spaces using a vector-based principal component analysis. These three methods have been tested on two non-redundant lists of protein families: one composed by proteins that bind a variety of ligand groups, and the other composed by proteins with annotated functionally relevant sites. In most cases, the residues predicted by the three methods show a clear tendency to be close to bound ligands of biological relevance and to those amino acids described as participants in key aspects of protein function. These three automatic methods provide a wide range of possibilities for biologists to analyze their families of interest, in a similar way to the one presented here for the family of proteins related with ras-p21. [less ▲]

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See detailPRODORIC: prokaryotic database of gene regulation
Münch, Richard; Hiller, Karsten UL; Barg, Heiko et al

in Nucleic Acids Research (2003)

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See detailCoal Basins
Leboutte, René UL

in Mokyr, Joel (Ed.) The Oxford Encyclopedia of Economic History, vol. 1 (2003)

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See detailL’Histoire longue de Cockerill Sambre
Leboutte, René UL

in Fusulier, Bernard (Ed.) Kaléidoscopie d’une modernisation industrielle : Usinor-Cockerill Sambre-Arcelor (2003)

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See detailCockerill John
Leboutte, René UL

in Mokyr, Joel (Ed.) The Oxford Encyclopedia of Economic History, vol. 1 (2003)

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See detailSteelmaking
Leboutte, René UL

in Mokyr, Joel (Ed.) The Oxford Encyclopedia of Economic History, vol. 5 (2003)

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See detailIntensive Energy Use in Early Modern Industrial Europe (17th-early 19th Century)
Leboutte, René UL

in Cavaciocchi, Simonette (Ed.) Economia e Energia secc. XIII-XVIII, XXXIV Settimana di Studi Il Datini (2003)

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See detailLe testing adaptatif par ordinateur dans la mesure en éducation: potentialités et limites
Martin, Romain UL

in Psychologie et Psychométrie (2003), 24(2-3), 89-116

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See detailSelf resources in advanced and old age - European study of adult well-being
Weber, Germain UL; Glück, Judith; Sassenrath, S. et al

Report (2003)

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See detailPhysical health and functional status. European Study of Adult Wel-being (ESAW): Comparative Report
Ferring, Dieter UL; Rahm-Hallberg, Ingalill; Windle, Gilles et al

Report (2003)

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See detailSocial Support Resources - European Study of Adult Well-Being Comparative report
Burholt, Vanessa UL; Wenger, G.; Lamura, G. et al

Report (2003)

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See detailMaterial Security- European Study of Adult Well-being (ESAW) Comparative report
Lamura, G.; Balducci, Christian; Melchiorre, M. G. et al

Report (2003)

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See detailComparative report on physical health and functional status
Ferring, Dieter UL; et, Al

Report (2003)

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See detailEl honor en las comedias de Lope de Vega
Gomez-Fernandez, Roberto UL

Scientific Conference (2003)

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See detailRe-Interpretation of Conceptualisation - A Contribution to the Advance of Design Theory
Bender, Bernd; Blessing, Lucienne UL

in Lindemann, Udo (Ed.) Human Behaviour in Design. Individuals, Teams, Tools (2003)

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See detailAdaptive tests of linear hypotheses by model selection
Baraud, Yannick UL; Huet, S.; Laurent, B.

in Ann. Statist. (2003), 31(1), 225--251

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