References of "2003"
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See detailInternationalisierung und nationale Kontexte der Forschung
Tröhler, Daniel UL

in Zeitschrift für Pädagogische Historiographie (2003), 9(1), 31-33

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See detailMolecular dynamics simulation of the unfolding of the human prion protein domain under low pH and high temperature conditions
Gu, Wei UL; Wang, T. T.; Zhu, J. et al

in Biophysical Chemistry (2003), 104(1), 79-94

Four 10-ns molecular dynamics (MD) simulations of the human prion protein domain (HuPrP 125-228) in explicit water solution have been performed. Each of the simulations mimicked a different environment of ... [more ▼]

Four 10-ns molecular dynamics (MD) simulations of the human prion protein domain (HuPrP 125-228) in explicit water solution have been performed. Each of the simulations mimicked a different environment of the protein: the neutral pH environment was simulated with all histidine residues neutral and bearing a ND proton and with other titratable side chains charged, the weakly acidic environment was simulated with all titratable side chains charged, he strongly acidic environment was simulated with all titratable side chains protonated. The protein in neutral pH environment was simulated at both ambient (298 K) and higher (350 K) temperatures. The native fold is stable in he neutral pH/ambient temperature simulation. Through out all other simulations, a quite stable core consisted of 0-20 residues around the disulfide bond retain their initial conformations. However, the secondary structures of the Protein show changes of various degrees compared to the native fold, parts of the helices unfolded and the beta-sheets extended. Our simulations indicated that the heat-induced unfolding and acid-induced unfolding of HuPrP might follow different pathways: the initial stage of the acid-induced unfolding may include not only changes in secondary structures, but also changes in the tertiary structures. Under the strongly acidic condition, obvious tertiary structure changes take place after 10-ns simulation, the secondary structure elements and the loops becoming more parallel to each other, resulting in a compact state, which was stabilized by a large number of new, non-native side chain-side chain contacts. Such tertiary structure changes were not observed in the higher temperature simulation, and intuitively, they may favor the further extension of the beta-sheets and eventually the agglomeration of multiple protein molecules. The driving forces for this tertiary structure changes are discussed. Two additional 10-ns MD simulations, one with Asp202 protonated and the other with Glu196 protonated compared to the neutral pH simulation, were carried out. The results showed that the stability of the native fold is very subtle and can be strongly disturbed by eliminating a single negative charge at one of such key sites. Correlations of our results with previous experimental and theoretical studies are discussed. (C) 2003 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailMEDAL: A CASE Tool Extension for Model-driven Software Engineering
Guelfi, Nicolas UL; Ries, Benoît UL; Sterges, Paul UL

in SwSTE'03 IEEE International Conference on Software - Science, Technology & Engineering (2003)

The complexity of today’s software systems leads to the creation of many related diagrams, representing different viewpoints, different levels of abstraction, and different implementation alternatives ... [more ▼]

The complexity of today’s software systems leads to the creation of many related diagrams, representing different viewpoints, different levels of abstraction, and different implementation alternatives. Model-driven software engineering places these models in the center of the development process. Tool support is an essential aspect of model-driven engineering. Of particular interest are model transformation tools: they can facilitate the creation and the evolution of models; they provide a level of traceability between them and they help keeping them synchronized. Unfortunately, currently there are few such tools for UML-based models. This paper presents MEDAL, our model transformation tool. First, we present our viewpoint on model-driven software engineering. Then we describe MEDAL and how we implemented MEDAL on top of Rational XDE. Finally, in the last section we show how a web application development that is based on an architectural framework can be supported by the MEDAL tool. [less ▲]

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See detailLuxemburg
Majerus, Benoît UL

in Hirschfeld, Gerhard; Krumeich, Gerd; Renz, Irina (Eds.) Enzyklopädie Erster Weltkrieg (2003)

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See detailPISA und Demokratie
Tröhler, Daniel UL

in PH Akzente (2003), 10(2), 24-25

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See detailC.7: Luxemburg
Margue, Michel UL; Pauly, Michel UL

in Paravicini, Werner (Ed.) Höfe und Residenzen im spätmittelalterlichen Reich. Ein dynastisch-topographisches Handbuch. (2003)

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See detailTechnological Spillovers of Financial Centers on a Regional Economy: A Macroeconomic Approach Applied to Luxembourg
Bourgain, Arnaud UL; Pieretti, Patrice UL

in Thierstein, Alain; Schamp, Eike (Eds.) Innovation, Finance and Space (2003)

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See detailIdentifying regional varieties by pitch information: A comparison of two approaches
Peters, Jörg; Gilles, Peter UL

in Solé, M. J.; Recasens, D.; Romero, J. (Eds.) Proceedings of the 15th International Congress of Phonetic Sciences, Barcelona, August 3-9, 2003 (2003)

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See detailWeighted Group Algebras on Groups of Polynomial Growth
Fendler, Gero; Gröchenig, Karlheinz; Leinert, Michael et al

in Mathematische Zeitschrift (2003), 245(4), 791-821

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See detailCharacterization of the simple L¹(G) -modules for exponential Lie groups
Ludwig, Jean; Mint Elhacen, Salma; Molitor-Braun, Carine UL

in Pacific Journal of Mathematics (2003), 212(1), 133-156

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See detailFermenta cognitionis. Hannah Arendts Hermeneutik des Nach-Denkens
Mein, Georg UL

in Deutsche Vierteljahrsschrift für Literaturwissenschaft und Geistesgeschichte (2003), 77(3), 481-511

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See detailL'influence de la loi Sarbanes-Oxley en France
Conac, Pierre-Henri UL

in Revue des Sociétés (2003), (4), 835-835

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See detailNotable results regarding temporal memory and modality.
Klapproth, Florian UL

in Helfrich, H. (Ed.) Time and mind II. Information processing perspectives. (2003)

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See detailDer Einfluss eines doppelten Standards auf das Zeitschätzungsverhalten.
Klapproth, Florian UL

in Golz, J.; Faul, F.; Mausfeld, R. (Eds.) Experimentelle Psychologie. Abstracts der 45. Tagung experimentell arbeitender Psychologen. (2003)

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See detailApports et limites des tests d'utilisabilité
van de Leemput, Cécile; Koenig, Vincent UL

in Delobbe, Nathalie; Karnas, Guy; Vandenberghe, Christian (Eds.) Evaluation et développement des compétences au travail (2003)

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See detailA modal model for temporal memory.
Klapproth, Florian UL

in Detje, F.; Dörner, D.; Schaub, H. (Eds.) The logic of cognitive systems. Proceedings of the fifth international conference on cognitive modelling. (2003)

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See detailCity vs. Bits. Von der Beschleunigung der Nachrichten und der Trägheit des Raumes.
Hesse, Markus UL

in Kommune (2003), 21(5), 99-104

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