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See detailPedagogy of Science: The Contribution of Pedagogy to the Philosophy of Science.
Biesta, Gert UL; Miedema, S.

in Phenomenology and Pedagogy (1990), 8

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See detailCardiac baroreflex function during postural change using non-invasive spontaneous sequence analysis in young men.
Steptoe, Andrew; Vögele, Claus UL

in Cardiovascular Research (1990), 24

STUDY OBJECTIVE: The aim was to assess the value of baroreflex sensitivity estimates calculated from analyses of spontaneous systolic blood pressure and pulse interval sequences derived from continuous ... [more ▼]

STUDY OBJECTIVE: The aim was to assess the value of baroreflex sensitivity estimates calculated from analyses of spontaneous systolic blood pressure and pulse interval sequences derived from continuous non-invasive finger blood pressure recordings during sitting and active standing. DESIGN: Continuous recordings of digital systolic blood pressure and pulse interval were obtained non-invasively using a Finapres FD5 during 5 min trials of sitting and standing. SUBJECTS: Subjects were healthy males aged 19-28, divided into those with "high" normal (n = 18) and "low" normal (n = 17) blood pressure. MEASUREMENTS AND MAIN RESULTS: Recordings were scanned for spontaneous sequences of three or more cardiac cycles over which systolic blood pressure increased progressively in conjunction with prolonged pulse interval, or decreased while pulse interval became shorter. Regressions between blood pressure and pulse interval (r greater than 0.80) provided estimates of cardiac baroreceptor reflex control. Computations were carried out with concurrent blood pressure and pulse interval measurements, and with a delay or lag of one and two cycles between the two variables. Pulse interval was reduced from an average 870.3 ms sitting to 571.3 ms on standing. Mean baroreflex sensitivity while sitting averaged 17.5 ms.mm Hg-1 at a delay of one cycle, failing to 7.65 ms.mm Hg-1 with standing. The decrease in sensitivity was correlated with the change in pulse interval between trials. The number of sequences was also significantly reduced with standing as opposed to sitting. Three cycle sequences were most frequent, with a lesser number of sequences involving 4, 5, and 6 or more cycles. No significant differences between "high" and "low" normal blood pressure groups were observed. CONCLUSIONS: The analysis of spontaneous sequences from non-invasive recordings may provide useful information concerning cardiac baroreflex control in different postural and behavioural states. A lag of one cycle between systolic blood pressure and pulse interval may provide the most representative estimates of baroreflex sensitivity. [less ▲]

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See detailVariations of cervical vertebrae after expression of a Hox-1.1 transgene in mice.
Kessel, M.; Balling, Rudi UL; Gruss, P.

in Cell (1990), 61(2), 301-8

To understand the function of murine homeobox genes, a genetic analysis is mandatory. We generated gain-of-function mutants by introducing genomic sequences of the Hox-1.1 gene under the control of a ... [more ▼]

To understand the function of murine homeobox genes, a genetic analysis is mandatory. We generated gain-of-function mutants by introducing genomic sequences of the Hox-1.1 gene under the control of a chicken beta-actin promoter into mice. Our previous data had shown that these transgenic mice are nonviable after birth and are born with craniofacial abnormalities. In a subsequent detailed analysis of severely affected animals, malformations of the basioccipital bone, the atlas, and the axis were observed. Manifestation of an additional vertebra, a proatlas, occurred at the craniocervical transition. The dominant interference of the Hox-1.1 transgene with developmental programs seems to occur around day 9 of gestation, the time of neural crest migration and somite differentiation. We discuss the resulting phenotype with respect to a developmental control function of Hox-1.1. [less ▲]

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See detailNeuropeptides and inflammation: presumed mechanisms in neurogenic inflammation
Landry, Y.; Bloch, J. G.; Mousli, M. et al

in Pathologie et Biologie (1990), 38(1), 53-6

Neuropeptides, among which substance P, VIP (Vasoactive intestinal peptide), somatostatin, neurotensin, dynorphin and enkephalins, are able to modulate inflammatory processes. Increasing interest is now ... [more ▼]

Neuropeptides, among which substance P, VIP (Vasoactive intestinal peptide), somatostatin, neurotensin, dynorphin and enkephalins, are able to modulate inflammatory processes. Increasing interest is now devoted to these peptides in different inflammatory diseases, concerning skin, lung and joins. The effect of substance P can be dependent on its C-terminal moiety implicating by this way an interaction with specific neurokinin receptors or can be dependent on its N-terminal moiety which does not involve a specific membrane receptor. Such diversity of the action mechanisms of peptides should influence the evolution of the anti-inflammatory therapeutic. [less ▲]

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See detailThe behaviour of the PSI (palmar sweat index) during two stressful laboratory situations.
Köhler, Thomas; Weber, Dittmar; Vögele, Claus UL

in Journal of Psychophysiology (1990), (4), 281-287

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See detailGlobal Charts of Ocean Tide Loading Effects
Francis, Olivier UL; Mazzega, P.

in Journal of Geophysical Research (1990), 95(C7), 11411-11424

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See detailG protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides
Mousli, M.; Bueb, Jean-Luc UL; Bronner, C. et al

in Trends in Pharmacological Sciences (1990), 11(9), 358-62

The neuropeptide substance P, the venom peptide mastoparan and the synthetic polyamine compound 48/80 activate rat peritoneal mast cells, leading to rapid histamine release by exocytosis. Although these ... [more ▼]

The neuropeptide substance P, the venom peptide mastoparan and the synthetic polyamine compound 48/80 activate rat peritoneal mast cells, leading to rapid histamine release by exocytosis. Although these effects are inhibited by pertussis toxin and involve a transient increase in IP3, no selective membrane receptors have been identified. However, it has recently been shown that these compounds activate G proteins in vitro. Here Yves Landry and colleagues discuss the proposal that direct activation of G protein is the physiological mechanism of action of substance P on rat peritoneal mast cells, this mechanism being mimicked by mastoparan and 48/80, and possibly by other cationic amphiphilic peptides such as kinins. These compounds might be of help in defining the interaction between membrane receptors and G proteins. [less ▲]

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See detailEvidence for the involvement of calcitonin gene-related peptide in the epithelium-dependent contraction of guinea-pig trachea in response to capsaicin
Tschirhart, Eric UL; Bertrand, C.; Theodorsson, E. et al

in Naunyn-Schmiedeberg's Archives of Pharmacology (1990), 342(2), 177-81

Capsaicin (10(-9) to 10(-5) M) contracted guinea-pig tracheal strips. Epithelium-containing tracheal strips developed a maximum active tension which was significantly higher than that observed in ... [more ▼]

Capsaicin (10(-9) to 10(-5) M) contracted guinea-pig tracheal strips. Epithelium-containing tracheal strips developed a maximum active tension which was significantly higher than that observed in epithelium-free strips. Anti-CGRP (calcitonin gene-related peptide) serum blocked the epithelium-dependent potentiation of the capsaicin-induced contraction in the intact tracheal strips, without affecting the response of the epithelium-free strips. This result suggests the occurrence of an epithelium-dependent release of CGRP. This same serum markedly reduced the contraction induced by exogenous rat CGRP in both intact and epithelium-free tracheal strips. In epithelium-free tracheal strips, capsaicin-induced contraction was abolished by spantide (10(-6) and 10(-5) M), a substance P antagonist, but, in intact tracheal strips, spantide did not abolish the capsaicin-induced contraction, showing that both CGRP and substance P release are directly induced by capsaicin. Moreover, the contractile responses to rat CGRP of intact tracheal strips from guinea pig suggest that CGRP itself might be able to release a contracting factor from the airway epithelium. Therefore, CGRP originating from the airway epithelium may play a major role in the control of airway smooth muscle tone. [less ▲]

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See detailKrichever-Novikov algebras for more than two points: explicit generators
Schlichenmaier, Martin UL

in Letters in Mathematical Physics (1990), 19(4), 327-336

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See detailPerception et mesure du vieillissement durant la transition démographique. Ménage, profession, retraite : la place du vieillard dans la société, XVIIIe-XXe siècles
Leboutte, René UL

in Loriaux, Michel (Ed.) Chaire Quetelet 1986. Populations âgées et révolution grise. Les hommes et les sociétés face à leurs vieillissement. (1990)

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See detailUsing Community Demographics in Social and Political Action
Powell, Justin J W UL

Report (1990)

Handbook for college community service programs

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See detailOct-4: a germline-specific transcription factor mapping to the mouse t-complex
Schöler, H. R.; Dressler, G. R.; Balling, Rudi UL et al

in EMBO journal (1990), (9), 2185-2195

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See detailDevelopment(s) in mouse genetics.
Balling, Rudi UL; Kessel, M.

in Biochemistry & Cell Biology (1990), 68(2), 404-7

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See detailLa demande de proroger ou de payer une garantie autonome, observation sur l'arrêt de la chambre commerciale de la Cour de cassation, du 24 janvier 1989
Prüm, André UL; Mattout, Jean-Pierre

in La Semaine Juridique - Entreprise et Affaires (1990), II

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See detailM2 World Ocean Tides from Tide Gauge and Gravity Loading Measurements
Francis, Olivier UL; Mazzega, Pierre

in Paquet, Paul; Flick, Johnny; Ducarme, Bernard (Eds.) GPS for Geodesy and (1990)

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