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See detailGenome-wide linkage analysis of families with primary hyperhidrosis
Schote, Andrea B.; Schiel, Florian; Schmitt, Benedict et al

in PLoS ONE (2020)

Primary focal hyperhidrosis (PFH, OMIM %144110) is a genetically influenced condition characterised by excessive sweating. Prevalence varies between 1.0–6.1% in the general population, dependent on ... [more ▼]

Primary focal hyperhidrosis (PFH, OMIM %144110) is a genetically influenced condition characterised by excessive sweating. Prevalence varies between 1.0–6.1% in the general population, dependent on ethnicity. The aetiology of PFH remains unclear but an autosomal dominant mode of inheritance, incomplete penetrance and variable phenotypes have been reported. In our study, nine pedigrees (50 affected, 53 non-affected individuals) were included. Clinical characterisation was performed at the German Hyperhidrosis Centre, Munich, by using physiological and psychological questionnaires. Genome-wide parametric linkage analysis with GeneHunter was performed based on the Illumina genome-wide SNP arrays. Haplotypes were constructed using easyLINKAGE and visualised via HaploPainter. Whole-exome sequencing (WES) with 100x coverage in 31 selected members (24 affected, 7 non-affected) from our pedigrees was achieved by next generation sequencing. We identified four genome-wide significant loci, 1q41-1q42.3, 2p14-2p13.3, 2q21.2-2q23.3 and 15q26.3-15q26.3 for PFH. Three pedigrees map to a shared locus at 2q21.2-2q23.3, with a genome-wide significant LOD score of 3.45. The chromosomal region identified here overlaps with a locus at chromosome 2q22.1-2q31.1 reported previously. Three families support 1q41-1q42.3 (LOD = 3.69), two families share a region identical by descent at 2p14-2p13.3 (LOD = 3.15) and another two families at 15q26.3 (LOD = 3.01). Thus, our results point to considerable genetic heterogeneity. WES did not reveal any causative variants, suggesting that variants or mutations located outside the coding regions might be involved in the molecular pathogenesis of PFH. We suggest a strategy based on whole-genome or targeted next generation sequencing to identify causative genes or variants for PFH. [less ▲]

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See detailMetaheuristics for the Online Printing Shop Scheduling Problem
Tessaro Lunardi, Willian UL; Birgin, Ernesto G.; Ronconi, Débora P. et al

in European Journal of Operational Research (2020)

In this work, the online printing shop scheduling problem introduced in (Lunardi et al., Mixed Integer Linear Programming and Constraint Programming Models for the Online Printing Shop Scheduling Problem ... [more ▼]

In this work, the online printing shop scheduling problem introduced in (Lunardi et al., Mixed Integer Linear Programming and Constraint Programming Models for the Online Printing Shop Scheduling Problem, Computers & Operations Research, to appear) is considered. This challenging real scheduling problem, that emerged in the nowadays printing industry, corresponds to a flexible job shop scheduling problem with sequencing flexibility; and it presents several complicating specificities such as resumable operations, periods of unavailability of the machines, sequence-dependent setup times, partial overlapping between operations with precedence constraints, and fixed operations, among others. A local search strategy and metaheuristic approaches for the problem are proposed and evaluated. Based on a common representation scheme, trajectory and populational metaheuristics are considered. Extensive numerical experiments with large-sized instances show that the proposed methods are suitable for solving practical instances of the problem; and that they outperform a half-heuristic-half-exact off-the-shelf solver by a large extent. Numerical experiments with classical instances of the flexible job shop scheduling problem show that the introduced methods are also competitive when applied to this particular case. [less ▲]

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See detailMetaheuristics for the Online Printing Shop Scheduling Problem - Supplementary Material
Tessaro Lunardi, Willian UL; Birgin, Ernesto G.; Ronconi, Débora P. et al

Report (2020)

This document presents further numerical results of the experiments concerning the classical instances of the flexible job shop scheduling problem, performed in (Lunardi et al., Metaheuristics for the ... [more ▼]

This document presents further numerical results of the experiments concerning the classical instances of the flexible job shop scheduling problem, performed in (Lunardi et al., Metaheuristics for the Online Printing Shop Scheduling Problem, submitted). Additionally, this document gathers the best makespan values (upper bounds and lower bounds) found by state-of-the-art algorithms. [less ▲]

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See detailCompetence-Orientation in Teaching Physical Education
Heck, Sandra UL; Scheuer, Claude UL

in Peters, Michael A. (Ed.) Encyclopedia of Teacher Education (2020)

In recent years, curriculum development has shifted to competence-oriented approaches in many European countries and beyond. Contents of the respective competence-oriented curricula may vary depending on ... [more ▼]

In recent years, curriculum development has shifted to competence-oriented approaches in many European countries and beyond. Contents of the respective competence-oriented curricula may vary depending on the specific cultural, social and political background, and accordingly also on the individual decision-makers. They may however comprehensively be defined as “a curriculum that emphasizes the complex outcomes of a learning process (i.e. knowledge, skills and attitudes to be applied by learners), rather than mainly focused on what learners are expected to learn about in terms of traditionally defined content” (UNESCO-International Bureau of Education, 2012). Competence-based curricula are thus criteria-based and goals-oriented, flexible and adaptive to students’ and school contexts. They have in common that learning outcomes are considered as an essential evidence of having acquired competencies. Further, they attest to the effectiveness of education systems at delivering quality education and effective learning. What learners can acquire, however, depends not only on a clear definition of intended competencies and learning outcomes. It is also related to questions like how the learning contents are packaged and presented, how they are taught, where they are taught and acquired, how learners are facilitated, and also how their acquisition is verified (UNESCO-International Bureau of Education, 2012). National and regional policies and curricula thus only pave the way to competence-oriented teaching. They can however only be successful if they are accepted and well implemented by the teacher and if they take place in a positive learning environment (UNESCO-International Bureau of Education, 2012). Accordingly, subject didactics in physical education like in any other subject have to cover two roles: contributing to determine educational standards and developing concepts for competence-oriented teaching (Gogoll & Kurz, 2013). Having this double mission in mind, this chapter is opening by exploring what competence-orientation means, first in general and secondly, more specifically, in physical education classes. It continues by transferring the theoretical knowledge into the practical implementation of competence-oriented tasks. To conclude, a critical glance is thrown on the concept of competence-orientation in physical education. [less ▲]

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See detailA Remote Carrier Synchronization Technique for Coherent Distributed Remote Sensing Systems
Merlano Duncan, Juan Carlos UL; Martinez Marrero, Liz UL; Querol, Jorge UL et al

in IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing (2020)

Phase, frequency, and time synchronization are crucial requirements for many applications, such as multi-static remote sensing and communication systems. Moreover, the synchronization solution becomes ... [more ▼]

Phase, frequency, and time synchronization are crucial requirements for many applications, such as multi-static remote sensing and communication systems. Moreover, the synchronization solution becomes even more challenging when the nodes are orbiting or flying on airborne or spaceborne platforms. This paper compares the available technologies used for the synchronization and coordination of nodes in distributed remote sensing applications. Additionally, this paper proposes a general system model and identifies preliminary guidelines and critical elements for implementing the synchronization mechanisms exploiting the inter-satellite communication link. The distributed phase synchronization loop introduced in this work deals with the self-interference in a full-duplex point to point scenario by transmitting two carriers at each node. All carriers appear with different frequency offsets around a central frequency, called the application central-frequency or the beamforming frequency. This work includes a detailed analysis of the proposed algorithm and the required simulations to verify its performance for different phase noise, AWGN, and Doppler shift scenarios. [less ▲]

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See detailA Narrative Review of Motor Competence in Children and Adolescents: What We Know and What We Need to Find Out
Lopes, Luis; Santos, Rute; Coelho e Silva, Manuel et al

in International Journal of Environmental Research and Public Health (2020), 18(1), 1-20

Lack of physical activity is a global public health problem causing not only morbidity and premature mortality, but it is also a major economic burden worldwide. One of the cornerstones of a physically ... [more ▼]

Lack of physical activity is a global public health problem causing not only morbidity and premature mortality, but it is also a major economic burden worldwide. One of the cornerstones of a physically active lifestyle is Motor Competence (MC). MC is a complex biocultural attribute and therefore, its study requires a multi-sectoral, multi-, inter- and transdisciplinary approach. MC is a growing area of research, especially in children and adolescents due to its positive association with a plethora of health and developmental outcomes. Many questions, however, remain to be answered in this field of research, with regard to: (i) Health and Developmental-related Associations of MC; (ii) Assessment of MC; (iii) Prevalence and Trends of MC; (iv) Correlates and Determinants of MC; (v) MC Interventions, and (vi) Translating MC Research into Practice and Policy. This paper presents a narrative review of the literature, summarizing current knowledge, identifying key research gaps and presenting questions for future investigation on MC in children and adolescents. This is a collaborative effort from the International Motor Competence Network (IMCNetwork) a network of academics and researchers aiming to promote international collaborative research and knowledge translation in the expansive field of MC. The knowledge and deliverables generated by addressing and answering the aforementioned research questions on MC presented in this review have the potential to shape the ways in which researchers and practitioners promote MC and physical activity in children and adolescents across the world. [less ▲]

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See detailDisorganized attachment in adolescence: Emotional and physiological dysregulation during the Friends and Family Interview and a conflict interaction
Decarli, Alessandro; Pierrehumbert, Blaise; Schulz, André UL et al

in Development and Psychopathology (2020)

The current study examined the effects of attachment on autonomy, relatedness and emotion regulation during an attachment interview (Friends and Family Interview; FFI) and a parent-child conflict ... [more ▼]

The current study examined the effects of attachment on autonomy, relatedness and emotion regulation during an attachment interview (Friends and Family Interview; FFI) and a parent-child conflict interaction (Family Interaction Task; FIT) in 49 adolescents (11 to 17 years old). Disorganized adolescents showed a steeper decrease in heart rate variability (HRV) than organized ones, during both the FFI and the FITs. Dismissing adolescents showed a more pronounced decrease in HRV during the FFI than secure and preoccupied individuals; no differences were found between these groups in HRV during the FITs. The results suggest that disorganized adolescents had more difficulties in regulating their emotions during both the FFI and the FITs, whereas dismissing individuals seemed effectively challenged only during the interview. [less ▲]

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See detailIWalk tours in Esch and Luxembourg city
Bronec, Jakub UL

Computer development (2020)

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See detailWind Music during the Nazi occupation in Luxembourg from 1940 to 1944
Sagrillo, Damien François UL

Scientific Conference (2020, December 18)

From 1940 to 1944 Luxembourg was governed by the National Socialist regime. Besides the many human destinies, social life also had to bear the consequences. The keyword is "Gleichschaltung" (co-ordination ... [more ▼]

From 1940 to 1944 Luxembourg was governed by the National Socialist regime. Besides the many human destinies, social life also had to bear the consequences. The keyword is "Gleichschaltung" (co-ordination). In my lecture, I will provide some examples to show how this abusive and arbitrary interference affected the activities of the music associations. [less ▲]

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See detailPerforming a historical re-enactment: the making of a 16mm home movie
van der Heijden, Tim UL

Presentation (2020, December 18)

In this presentation, I will “perform” the making of a 16mm home movie based on my media archaeological experiments with an original Ciné-Kodak film camera from 1930. A split screen montage shows the ... [more ▼]

In this presentation, I will “perform” the making of a 16mm home movie based on my media archaeological experiments with an original Ciné-Kodak film camera from 1930. A split screen montage shows the recorded analogue film fragments besides footage that illustrates the process of making the film captured by my documentation equipment, including a digital video camera, GoPro and 360 degree camera. My contribution aims to discuss and re-evaluate the performative nature of media archaeological experiments, and how digital (documentation) tools enable new forms of presentation, explication and dissemination of historical tacit knowledge in early-twentieth century amateur filmmaking. [less ▲]

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See detailA Case Driven Study of the Use of Time Series Classification for Flexibility in Industry 4.0
Polge, Julien UL; Robert, Jérémy UL; Le Traon, Yves UL

in Sensors (2020), 20(24),

With the Industry 4.0 paradigm comes the convergence of the Internet Technologies and Operational Technologies, and concepts, such as Industrial Internet of Things (IIoT), cloud manufacturing, Cyber ... [more ▼]

With the Industry 4.0 paradigm comes the convergence of the Internet Technologies and Operational Technologies, and concepts, such as Industrial Internet of Things (IIoT), cloud manufacturing, Cyber-Physical Systems (CPS), and so on. These concepts bring industries into the big data era and allow for them to have access to potentially useful information in order to optimise the Overall Equipment Effectiveness (OEE); however, most European industries still rely on the Computer-Integrated Manufacturing (CIM) model, where the production systems run as independent systems (i.e., without any communication with the upper levels). Those production systems are controlled by a Programmable Logic Controller, in which a static and rigid program is implemented. This program is static and rigid in a sense that the programmed routines cannot evolve over the time unless a human modifies it. However, to go further in terms of flexibility, we are convinced that it requires moving away from the aforementioned old-fashioned and rigid automation to a ML-based automation, i.e., where the control itself is based on the decisions that were taken by ML algorithms. In order to verify this, we applied a time series classification method on a scale model of a factory using real industrial controllers, and widened the variety of parts the production line has to treat. This study shows that satisfactory results can be obtained only at the expense of the human expertise (i.e., in the industrial process and in the ML process). [less ▲]

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See detailMultipath Mitigation Maps feasibility and applicability as an International GNSS Service product
Hunegnaw, Addisu UL; Teferle, Felix Norman UL; Elgered, Gunnar et al

Scientific Conference (2020, December 17)

There have been many advances in the modeling of Global Navigation Satellite System (GNSS) observables when estimating position and other parameters of interest. Some of these bias models are related to ... [more ▼]

There have been many advances in the modeling of Global Navigation Satellite System (GNSS) observables when estimating position and other parameters of interest. Some of these bias models are related to improvements of reference frames, phase center offsets and variations of transmitter and receiver antennas, satellite orbits and clocks, and troposphere. Nonetheless, multipath remains for the most part an unmodelled source of error which causes range errors in the GNSS observations. The associated effects show highly localized features and have a different impact for each receiver and antenna. Multipath errors can propagate, can cause in-situ position biases and are also contributing to the prevalent draconitic harmonic signals. In order to mitigate the problem we generate site-specific corrections by employing a suitable averaging scheme for the stacking of carrier phase residuals. Our processing is based on globally distributed static multi-GNSS observations using several scientific GNSS software packages (Bernese GNSS Software, NAPEOS, GAMIT-GLOBK, and CSRS-PPP). Our multipath stacking maps (MPS) use the stacking of carrier phase residuals generated by variable azimuth cell size (congruent cells) and by allocating carrier phase residuals in each cell to generate the correction maps, unlike the standard fixed azimuth cell resolution approaches. This reduces the binning of fewer residuals at higher elevation angles. Before stacking, we also apply rigorous statistical outlier screening tests for each one-way post-fit carrier phase residual assigned to each of the congruent cells. We thus correct the multipath effects by subtracting the stacked multipath map from the post-fit carrier phase residual. Using this technique we produce a model available in the form of the Antenna Exchange (ANTEX) file format, that can potentially be implemented in routine GNSS analysis with no or little additional overhead for individual analysis centers (ACs). In this study, we assess the feasibility and applicability of the MPS maps as an International GNSS Service (IGS) product for routine GNSS analysis. We demonstrate the multipath stacking technique to result in a significant reduction of the variation in the one-way post-fit carrier phase residuals from multi-GNSS observations. [less ▲]

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See detailUnlawful Content Online: Towards A New Regulatory Framework For Online Platforms
Ullrich, Carsten UL

Doctoral thesis (2020)

The thesis reviews the online intermediary liability framework of the E-Commerce Directive (in Articles 12 - 15) along two research questions. 1) Is the current legal framework regulating content ... [more ▼]

The thesis reviews the online intermediary liability framework of the E-Commerce Directive (in Articles 12 - 15) along two research questions. 1) Is the current legal framework regulating content liability of online platforms under the ECD still adequate when it comes to combating illegal content? 2) Are there alternative models for intermediary regulation that are better suited to include internet intermediaries in the fight against illegal content? These questions were formulated against the premises that unlawful content online has been a persisting and growing problem and that the position of online intermediaries today makes enhanced responsibilities on their part necessary. The thesis undertakes to analyse the nature of the enforcement challenges in the EU when trying to engage online platforms under the current liability framework, and charts out an alternative approach to holding online platforms responsible. Chapter 3 reviews the current intermediary framework in the EU and the horizontal challenges of holding internet intermediaries liable. This is analysed against the backdrop of the proliferation of the internet and online platforms, sketched out in the preceding Chapter 2. Due to the ambiguity and outdatedness of the ECD provisions, on the one hand, and different national secondary liability traditions, on the other hand, the liability protections of online platforms have been interpreted and applied differently by EU Member States, and most importantly courts, leading to an uneven and ineffective enforcement landscape. Chapter 4 analyses sectoral provisions that cover different kinds of offences related to unlawful content and their interactions with the ECD and national legislation on intermediary liability. The thesis evaluates enforcement efforts in the areas of defamation, hate speech, terrorist content, copyright, trademarks, product safety and food safety. While none of the national (sectoral) approaches reviewed appear to be effective when trying to enlist intermediaries in the fight against unlawful content, the latter have built up powerful own private enforcement systems that have come to rival and run counter to public interests and fundamental rights. Chapter 5 introduces case studies of online enforcement in the areas of product and food safety, based on interviews conducted with market surveillance authorities in the EU. The specific enforcement system of EU product regulation poses particular challenges, but also offers some useful lessons for the eventual framework proposed in Chapter 6. This system eschews today’s liability cornerstones and the reliance of self-regulatory tools favoured by EU and national legislators so far. Instead it proposes an enhanced responsibility system, based on harmonised technical standards as used in the EU's New Approach regulatory method. Technical standards would define duty of care obligations in the guise of risk management approaches, which focus on defined (sectoral) harms that arise from the business practices of online platforms. They incorporate prospective responsibilities, such as for example safety by design for user onboarding, user empowerment, or (algorithmic) content management, as well as specific retrospective responsibilities relating to e.g. notice and takedown or content identification system. The standard can be adapted to the type of harm/violation, thus taking account of the specific fundamental rights and public interests involved on a sectoral level. [less ▲]

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See detailVertical Land Movements and Sea Level Changes on South Georgia, South Atlantic Ocean: Results from 7 Years of Geodetic and Oceanographic Observations on a Remote Island
Teferle, Felix Norman UL; Hunegnaw, Addisu UL; Hibbert, Angela et al

Scientific Conference (2020, December 16)

South Georgia Island in the South Atlantic Ocean, is a small remote land mass that supports various ground-based instrumental observations (Global Navigation Satellite System (GNSS), tide gauge ... [more ▼]

South Georgia Island in the South Atlantic Ocean, is a small remote land mass that supports various ground-based instrumental observations (Global Navigation Satellite System (GNSS), tide gauge, meteorological and seismic) in an otherwise largely under sampled oceanic region. Moreover, the South Atlantic Ocean plays an important role in global ocean circulation, con-necting the deep thermohaline circulation of the North Atlantic and Indian Oceans, whilst also linking to the Antarctic Circumpolar Current in the South, where the lack of continental barriers allows a free exchange of water between the major ocean basins. Hence, South Georgia po-tentially lies within a region susceptible to climatic changes before these can be felt further afield. In 2013 and 2014 a total of five GNSS stations were installed covering the area of the main island (approximately 170 x 50 km) with two of those being located close to the King Edward Point (KEP) Research Station and the GLOSS tide gauge (ID 187). Furthermore, precise levelling campaigns in 2013, 2014, 2017 and 2020 supported the analysis of local ground instabilities near the tide gauge. Through these activities the tide gauge datum within the Permanent Ser-vice for Mean Sea Level (PSMSL) has been established, which in turn, makes the derived KEP mean sea level (MSL) record highly valuable for long-term studies and satellite altimetry cali-brations. In this study, we will present the vertical land movement estimates from seven years of GNSS observations, five precise levelling campaigns, and will discuss their impact on the sea level record from the KEP tide gauge and nearby satellite altimetry sea surface heights. Our results confirm uplift all over South Georgia Island while the area at KEP and particularly the jetty with tide gauge are subsiding relative to the rest of the island. Using this information we correct the MSL record for the vertical land movements and investigate its signals together with those from nearby satellite altimetry tracks. [less ▲]

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See detailViolence Against Female Doctors, its influence on professional mental health and prevention
Tkachenko, Victoria; Tekin, Nil; Kurpas, Donata et al

in The World Book of Family Medicine (2020)

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See detailOutdoor STEAM integrated framework in elementary schools in Luxembourg using MathCityMap and GeoGebra 3D Calculator
Haas, Ben; Kreis, Yves UL; Lavicza, Zsolt

Scientific Conference (2020, December 15)

In elementary schools in Luxemburg, sciences and mathematics are generally taught in class based essentially on textbooks. However, the findings of multiple studies on understanding and applying skills in ... [more ▼]

In elementary schools in Luxemburg, sciences and mathematics are generally taught in class based essentially on textbooks. However, the findings of multiple studies on understanding and applying skills in STEAM (Science, Technology, Engineering, Arts and Mathematics) report that students need hands-on activities on real-world objects. Furthermore, in times of the COVID-19 pandemic, where numerous restrictions and risks dominate teaching inside the classroom, outdoor learning is safer and offers many opportunities. Hence, we created outdoor mathematical trails with a STEAM integrated approach for elementary schools using the free educational software MathCityMap and the dynamic mathematics software GeoGebra 3D. In these outdoor trails, students used a set of promising technologies, i.e. AR (Augmented Reality) or GPS, to support STEAM education. Based on results from our first study on outdoor mathematical trails in June 2020 (in review), we developed and evaluated a framework on outdoor STEAM integrated teaching. This framework was used for further outdoor task and trail creations in elementary schools, which we investigated by conducting semi-structured interviews with students and teachers. Hence, we will present how this framework was used in elementary schools to create outdoor mathematical trails and describe how it affected the students' learning. [less ▲]

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