Facing language heterogeneity: Do plurilingual learning and assessment environments create better results?

Poster (2006, December 09)

Entwicklung von hybriden Mauersteinen mit verbesserten wärmedämmenden Eigenschaften

Presentation (2006, December)

'If I don't learn English I'm going to suffer': Gambian lower basic school's children's perspective on the importance of English

in Cheung, Siu-Keung; Traver, Harold; Li, Xiuguo (Eds.) Proceedings of the 8th Annual Conference of the Hong Kong Sociological Association (2006, December)

Gesetzliche Mitwirkungspflichten der Kreditwirtschaft bei der Geldwäsche - und Terrorismusbekämpfung

Doctoral thesis (2006)

Statistische Mechanik harter Stäbchen

Presentation (2006, November 10)

Schulklima und Gewalt - Ein Überblick zum aktuellen Forschungsstand

Scientific Conference (2006, November)

Jaks and cytokine receptors - an intimate relationship

in Biochemical Pharmacology (2006), 72(11), 1538-46

Most cytokine receptors lack intrinsic kinase activity and many of them signal via Janus kinases (Jaks). These tyrosine kinases are associated with cytokine receptor subunits, they become activated upon ... [more ▼]

Most cytokine receptors lack intrinsic kinase activity and many of them signal via Janus kinases (Jaks). These tyrosine kinases are associated with cytokine receptor subunits, they become activated upon receptor triggering and subsequently activate downstream signalling events, e.g. the phosphorylation of STAT transcription factors. The successful interplay between cytokines, their receptors and the connected Jaks not only determines signalling competence but is also vital for intracellular traffic, stability, and fate of the cognate receptors. Here, we will discuss underlying mechanisms as well as some structural features with a focus on Jak1 and two of the signal transducing receptor subunits of interleukin (IL)-6 type cytokines, gp130 and OSMR. Regions that are critically involved in Jak-binding have been identified for many cytokine receptor subunits. In most cases the membrane-proximal parts comprising the box1 and box2 regions within the receptor are involved in this association while, within Jaks, the N-terminal FERM domain, possibly together with the SH2-like domain, are pivotal for binding to the relevant receptors. The exclusive membrane localisation of Jaks depends on their ability to associate with cytokine receptors. For gp130 and Jak1, it was shown that the cytokine receptor/Jak complex can be regarded as a receptor tyrosine kinase since both molecules have the same diffusion dynamics and are virtually undissociable. Furthermore, Jaks take an active role in the regulation of the surface expression of at least some cytokine receptors, including the OSMR and this may provide a quality control mechanism ensuring that only signalling-competent receptors (i.e. those with an associated Jak) would be enriched at the cell surface. [less ▲]

Perspectives de psychologie différentielle

Book published by Presses Universitaires de Rennes (2006)

Développement et évaluation d'un test mahématique adapté, administré par ordinateur

Presentation (2006, October 19)

Les femmes entrepreneures et la transmission d’entreprise

in AIREPME (Ed.) Actes du 8ème CIFEPME (2006, October)

Cette communication présente des résultats de recherche afférant à la reprise d’entreprise familiale par des filles d’entrepreneurs. Nous identifions les différentes stratégies mises en oeuvre par les ... [more ▼]

Cette communication présente des résultats de recherche afférant à la reprise d’entreprise familiale par des filles d’entrepreneurs. Nous identifions les différentes stratégies mises en oeuvre par les femmes repreneuses dans ce contexte d’entreprise familiale pour asseoir leur crédibilité et affirmer leur identité de femmes chefs d’entreprise. Ces stratégies peuvent se concevoir en termes de choix des personnes-clés dans leur entourage, de développement de compétences spécifiques, de gestion des ressources humaines, ou de comportements en matière financière et bancaire. [less ▲]