References of "1984"
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See detailBerlin: Strukturen und Probleme einer geteilten Stadt
Ehrhart, Sabine UL

Article for general public (1984)

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See detailCholesterol and its oxidized derivatives modulate the calcium channel in human red blood cells.
Neyses, Ludwig UL; Stimpel, M.; Locher, R. et al

in Journal of Hypertension. Supplement) (1984), 2(3), 489-92

The human red blood cell was used as a model system in order to study the effect of cholesterol and its medically important oxidized derivatives (OSC = oxidized sterol compounds) on the calcium entry ... [more ▼]

The human red blood cell was used as a model system in order to study the effect of cholesterol and its medically important oxidized derivatives (OSC = oxidized sterol compounds) on the calcium entry channel. The calcium-ejecting adenosine triphosphatase (ATPase) was inhibited by vanadate and the influx of 45Ca2-into the cells measured. The cells were loaded with OSC at concentrations between 0.075 and 1.5 micrograms OSC/10(7) cells. Two classes of OSC could be distinguished: one stimulating Ca2+ influx dose-dependently by almost 100% at maximum concentrations, the other inhibiting it dose-dependently by up to 80%. The calcium channel blocker nitrendipine inhibited influx by 70% at 15 microM. More than 90% of the total stimulation or inhibition was accounted for by an influence on the nitrendipine-inhibitable part of influx, i.e. the calcium channel. Cholesterol (incorporated using liposomes) had a stimulatory (+288%), cholesterol depletion an inhibitory effect on calcium influx (-18%). These results demonstrate that cholesterol and its oxidized derivatives modulate the calcium channel in a highly stereospecific manner and provide new insights into the mechanism of action and the atherogenic effect of these compounds. [less ▲]

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See detailVascular reactions correlated with pain due to cold
Kreh, Albrecht; Anton, Fernand UL; Gilly, Hermann et al

in Experimental Neurology (1984), 85(3), 533-546

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See detailAlgesimetry using natural stimuli of long duration
Anton, Fernand UL; Kreh, Albrecht; Reeh, Peter-Werner et al

in Bromm, Burkhart (Ed.) Pain measurement in man. Neurophysiological correlates of pain. (1984)

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See detailRethinking Protoindustrialization and the Family
Leboutte, René UL; Gutmann

in Journal of Interdisciplinary History (1984), 14(3), 587-607

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See detailAngiotensin II binding to human mononuclear cells: receptor or free fluid endocytosis?
Neyses, Ludwig UL; Locher, R.; Wehling, M. et al

in Clinical Science (1984), 66(5), 605-12

It has recently been claimed that there are angiotensin II (ANG II) receptors on human mononuclear cells and on platelets and this has been used for investigating the regulation of the renin-angiotensin ... [more ▼]

It has recently been claimed that there are angiotensin II (ANG II) receptors on human mononuclear cells and on platelets and this has been used for investigating the regulation of the renin-angiotensin system in hypertension. We here show the following. Binding kinetics of 125I-labelled ANG II and [3H]ANG II to mononuclear cells were slow (maximum at 90 min) and the same as for [3H]-inulin. As with [3H]inulin there was no binding at 4 degrees C. Release from the cells was slow and incomplete (about 30% after 15 min, 60% after 60 min). Binding was not saturable over a range from 10(-12) to 10(-6) mol of ANG II/l, about 8% of offered peptide being bound at all concentrations. Various inhibitors of free fluid endocytosis exhibited the same inhibition pattern of ANG II binding to mononuclear cells. Therefore uptake of ANG II into mononuclear cells displayed all the features of free fluid endocytosis. ANG II was degraded by carboxypeptidase A. When this degradation was prevented by D-phenylalanine, no binding occurred. In platelet preparations contaminated by 0.3-5% of mononuclear cells, 125I-labelled ANG II was degraded as well. Free fluid endocytosis of the degradation product strongly depended on the percentage of contaminating mononuclear cells. We conclude that there are no ANG II receptors on human mononuclear cells and that their presence on human platelets is doubtful. [less ▲]

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See detailHuman red blood cells--an ideal model system for the action of calcium agonists and antagonists.
Stimpel, M.; Neyses, Ludwig UL; Locher, R. et al

in Journal of Hypertension. Supplement) (1984), 2(3), 577-80

To characterize the pharmacological properties of the slow calcium channel of human red blood cells, we studied the action of various calcium antagonists and two agonists on the 45Ca2+-influx. The Ca2 ... [more ▼]

To characterize the pharmacological properties of the slow calcium channel of human red blood cells, we studied the action of various calcium antagonists and two agonists on the 45Ca2+-influx. The Ca2+-ejecting ATPase was inhibited by vanadate. All dihydropyridine derivatives tested showed their inhibiting or stimulating effect on the channel at concentrations attainable in vivo (nitrendipine:Ki = 2.5; Bayer K 6244:Ki 5 microM; nicardipine:Ki = 15 microM, Ks = 0.5 microM; Ciba 28 392:Ki = 20, Ks = 0.3 microM; Ki = inhibition constant, Ks = stimulation constant). Of special interest was the biphasic behaviour (stimulation and inhibition) of the calcium antagonist nicardipine and the agonist Ciba 28 392. The maximum inhibition by the phenylalkylamine derivative verapamil was obtained at much higher concentrations (250 microM; Ki = 100). These data suggest that the calcium channel of human red blood cells has pharmacological properties very similar to the channel in heart and smooth muscle cells with respect to dihydropyridine action. Therefore, human red blood cells are an ideal model to study the action of calcium agonists and antagonists. [less ▲]

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See detail[Nifedipine in hypertensive emergencies and severe hypertension].
Groth, H.; Foerster, E. C.; Neyses, Ludwig UL et al

in Schweizerische Rundschau für Medizin Praxis (1984), 73(2), 45-9

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See detailNon-equilibrium Phase Transitions with Hysteresis in Solid Catalysis. The System Copper-Oxygen-Propene
Greger, Manfred UL; Ihme, Birgit; Kotter, Michael et al

in Berichte der Bunsengesellschaft für physikalische Chemie (1984), 88

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See detailThe cholesterol content of the human erythrocyte influences calcium influx through the channel.
Locher, R.; Neyses, Ludwig UL; Stimpel, M. et al

in Biochemical and biophysical research communications (1984), 124(3), 822-8

In order to study the influence of the cholesterol content on the calcium entry channel, the human red blood cell was used as a model system. The cholesterol to lecithin ratio (C/L ratio) of the membrane ... [more ▼]

In order to study the influence of the cholesterol content on the calcium entry channel, the human red blood cell was used as a model system. The cholesterol to lecithin ratio (C/L ratio) of the membrane was modified experimentally by incubating the cells (15h, 25 degrees) with liposomes of defined C/L ratios. Subsequently, net 45Calcium-influx into the cell was measured by inhibiting the Ca-ejecting ATPase with vanadate. Additionally, the use of nitrendipine, a potent calcium channel inhibitor, during incubation allowed the determination of Ca-influx through the calcium channel. A positive correlation between the 45Ca++-influx and the molar C/L ratio of the membrane was found over a wide C/L range. A molar C/L ratio of 1.4 in the membrane increased calcium influx by 150 % compared to controls (molar C/L ratio = 0.8, calcium influx rate = 100 %), while a molar C/L ratio at less than 0.75 decreased calcium influx by 50 %. We conclude, that the cholesterol content of the membrane greatly influences the calcium channel and thus plays a pivotal role for the availability of calcium as a second messenger. These findings may provide a link between high plasma cholesterol and the development of atherosclerosis as well as enhanced platelet aggregability. [less ▲]

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See detailPolizei und Demonstration - zur subjektiven Perspektive junger Polizeibeamter
Willems, Helmut UL; Werner-Reheuer

in Erwachsenenbildung (1984), (2),

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See detailRéminiscences des maîtres anciens et éléments modernes dans le réalisme de Claudio Bravo
Dell, Paul UL

Bachelor/master dissertation (1984)

At the beginning of his career, Claudio Bravo became known as a portraitist of the jet set people. Yet, to reduce him on these activities would not do justice to him. In fact, he was a neo-realistic ... [more ▼]

At the beginning of his career, Claudio Bravo became known as a portraitist of the jet set people. Yet, to reduce him on these activities would not do justice to him. In fact, he was a neo-realistic painter with many facets. His trompe-l’oeil paintings showed that Bravo was fascinated by form and texture of the represented characters or objects. The artist tried in same way to give the signs of reality a metaphysical presence: Conceptually significance should go beyond their outward appearance. Just as his technique, his paintings become statements of perfection. Compared to his contemporary mainstream fellows, his approach was somehow an anachronism. He borrowed iconographic content or image composition from famous artist of the past such as Rafael, Caravaggio, Velasquez, Titian or Manet, in order to transform the appropriations with his hyper-realistic technique into a modern version, stating a touch of timelessness, due to the sobriety of the decoration and time neutral garment of the protagonists. He had also formal affinities to photo- or hyper-realistic US-painters of the 1960s such as Estes, Close and Goings or even the American illustrator Rockwell. His package wrapped subject paintings were obviously inspired by the smaller cloth enveloped and tied up objects of an early Christo. Pop artists gave also inspiration with their representation of banal consumer objects. However, Bravo did not share the message of the pop artists, who were critical time spirit oriented reporters of popular consuming routines in a society that was switching more and more to futility and sometimes vulgar communication. This lack of a deeper message, going beyond celebrating the aesthetics of super-realistic representation, was pointed out by many art critics, committed to a more contemporary view on art. When Bravo painted a pop icon like a Coca-Cola bottle or a moto-sport helmet, his inherent interest focused on the fidelity to the outward appearance and conceptually on a metaphysical sublimation of its mere physical presence. The research deals with the above mentioned questions and discusses whether the approach of Bravo was simple epigonism or an authentic renewal of realistic painting. [less ▲]

Detailed reference viewed: 185 (14 UL)
See detailDeontic, Axiological and Epistemic Distance in Graham Greene's The Honorary Consul
Weber, Jean-Jacques UL

in Nottingham Linguistic Circular (1984), 13

Detailed reference viewed: 142 (1 UL)
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See detailELECTROOPTIC PROPERTIES OF Rb//2ZnCl//4 IN THE INCOMMENSURATE AND FERROELECTRIC PHASES
Sanctuary, Roland UL; Guenter, P.

in Physica Status Solidi A. Applied Research (1984), 84(1), 103-111

The electrooptic coefficients for light propagation directions along three crystallographic axes were measured in the temperature range from 100 to 220 K. A Landau-type free energy expansion describes ... [more ▼]

The electrooptic coefficients for light propagation directions along three crystallographic axes were measured in the temperature range from 100 to 220 K. A Landau-type free energy expansion describes temperature dependence. [less ▲]

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See detailAsparagine and glutamine metabolism in chicks.
Coon, C.; Balling, Rudi UL

in Poultry Science (1984), 63(4), 717-29

In a series of four experiments, asparaginase and glutaminase activity was measured in liver and kidney tissue of 7- to 19-day-old male broiler chicks. In Experiment 1, chicks were fed purified amino acid ... [more ▼]

In a series of four experiments, asparaginase and glutaminase activity was measured in liver and kidney tissue of 7- to 19-day-old male broiler chicks. In Experiment 1, chicks were fed purified amino acid diets with 14.8 and 44.6% protein equivalents (PE) with 1, 3, or 5% added sodium bicarbonate. In Experiments 2, 3, and 4 the chicks were fed a 23% protein basal control diet, basal diet containing 5% ammonium chloride, and basal diet containing 5% ammonium chloride with 5 or 10% sodium bicarbonate, asparagine, or glutamine. In Experiments 2 and 4 the chicks were also fed 25, 50, or 75% protein-isolated soy-purified diets. The 44.6% PE diet increased liver and kidney asparaginase activity in chicks as compared to chicks fed a 14.8% PE diet. The addition of sodium bicarbonate to the 44.6% PE amino acid diet decreased the kidney asparaginase activity equivalent to kidney asparaginase activity of chicks fed the 14.8% PE diet. Asparaginase activity increased 4-fold in the kidneys of chicks fed the 23% protein basal diet containing 5% ammonium chloride and the pH of the urine from the chicks was 4.9. Chicks fed basal diets with 5% ammonium chloride plus 10% sodium bicarbonate or asparagine had the same kidney asparaginase activity and urine pH as chicks fed the 23% protein basal control diet. Glutamine added to chick diets containing 5% ammonium chloride did not decrease the kidney asparaginase activity or the urine acidity. Liver asparaginase activity was not increased in acidotic chicks fed diets with 5% ammonium chloride. The asparaginase activity of liver and kidney tissue were both significantly increased in chicks fed 75% protein-isolated soy purified diets and the pH of their urine was 5.6. The increase in liver asparaginase of chicks fed 75% protein or 44.5% PE diets was probably due to an endocrine gluconeogenic response producing increased catabolism of the majority of amino acids. The increase in kidney asparaginase of chicks fed 75% protein, 44.5% PE diets, and 23% protein basal diets with 5% ammonium chloride was primarily related to metabolic acidosis. Phosphate-dependent glutaminase (PDG) activity was localized in chick kidney mitochondria and was heat sensitive (55 C for 30 sec). The phosphate-independent glutaminase (PIG) activity was primarily localized in chick kidney mitochondria but was stable to a temperature of 55 C for 30 sec.(ABSTRACT TRUNCATED AT 400 WORDS) [less ▲]

Detailed reference viewed: 181 (1 UL)