References of "van Wijland, F."
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See detailNonequilibrium dissipation in living oocytes
Fodor, Etienne UL; Ahmed, W. W.; Almonacid, M. et al

in EPL (2016), 116(3),

Living organisms are inherently out-of-equilibrium systems. We employ recent developments in stochastic energetics and rely on a minimal microscopic model to predict the amount of mechanical energy ... [more ▼]

Living organisms are inherently out-of-equilibrium systems. We employ recent developments in stochastic energetics and rely on a minimal microscopic model to predict the amount of mechanical energy dissipated by such dynamics. Our model includes complex rheological effects and nonequilibrium stochastic forces. By performing active microrheology and tracking micronsized vesicles in the cytoplasm of living oocytes, we provide unprecedented measurements of the spectrum of dissipated energy. We show that our model is fully consistent with the experimental data and we use it to offer predictions for the injection and dissipation energy scales involved in active fluctuations. Copyright (C) EPLA, 2016 [less ▲]

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See detailActivity-driven fluctuations in living cells
Fodor, Etienne UL; Guo, M.; Gov, N. S. et al

in EPL (2015), 110(4),

We propose a model for the dynamics of a probe embedded in a living cell, where both thermal fluctuations and nonequilibrium activity coexist. The model is based on a confining harmonic potential ... [more ▼]

We propose a model for the dynamics of a probe embedded in a living cell, where both thermal fluctuations and nonequilibrium activity coexist. The model is based on a confining harmonic potential describing the elastic cytoskeletal matrix, which undergoes random active hops as a result of the nonequilibrium rearrangements within the cell. We describe the probe's statistics and we bring forth quantities affected by the nonequilibrium activity. We find an excellent agreement between the predictions of our model and experimental results for tracers inside living cells. Finally, we exploit our model to arrive at quantitative predictions for the parameters characterizing nonequilibrium activity such as the typical time scale of the activity and the amplitude of the active fluctuations. Copyright (C) EPLA, 2015 [less ▲]

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See detailModeling the dynamics of a tracer particle in an elastic active gel
Ben-Isaac, E.; Fodor, Etienne UL; Visco, P. et al

in PHYSICAL REVIEW E (2015), 92(1),

The internal dynamics of active gels both in artificial (in vitro) model systems and inside the cytoskeleton of living cells has been extensively studied with experiments of recent years. These dynamics ... [more ▼]

The internal dynamics of active gels both in artificial (in vitro) model systems and inside the cytoskeleton of living cells has been extensively studied with experiments of recent years. These dynamics are probed using tracer particles embedded in the network of biopolymers together with molecular motors, and distinct nonthermal behavior is observed. We present a theoretical model of the dynamics of a trapped active particle, which allows us to quantify the deviations from equilibrium behavior, using both analytic and numerical calculations. We map the different regimes of dynamics in this system and highlight the different manifestations of activity: breakdown of the virial theorem and equipartition, different elasticity-dependent ``effective temperatures,'' and distinct non-Gaussian distributions. Our results shed light on puzzling observations in active gel experiments and provide physical interpretation of existing observations, as well as predictions for future studies. [less ▲]

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See detailEnergetics of active fluctuations in living cells
Fodor, Etienne UL; Kanazawa, K.; Hayakawa, H. et al

in PHYSICAL REVIEW E (2014), 90(4),

The nonequilibrium activity taking place in a living cell can be monitored with a tracer embedded in the medium. While microrheology experiments based on optical manipulation of such probes have become ... [more ▼]

The nonequilibrium activity taking place in a living cell can be monitored with a tracer embedded in the medium. While microrheology experiments based on optical manipulation of such probes have become increasingly standard, we put forward a number of experiments with alternative protocols that, we claim, will provide insight into the energetics of active fluctuations. These are based on either performing thermodynamiclike cycles in control-parameter space or determining response to external perturbations of the confining trap beyond simple translation. We illustrate our proposals on an active itinerant Brownian oscillator modeling the dynamics of a probe embedded in a living medium. [less ▲]

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