References of "Zagà, Vincenzo"
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See detailInfluenza del fumo di tabacco sui trattamenti farmacologici
Zagà, Vincenzo; Lygidakis, Charilaos UL; Pozzi, Paolo et al

in Tabaccologia (2013), (1), 35-47

Cigarette smoke, that contains more than 4.000 substances, may directly or indirectly influences the efficacy and the tolerability of many medications through complex pharmacokinetic and pharmacodinamic ... [more ▼]

Cigarette smoke, that contains more than 4.000 substances, may directly or indirectly influences the efficacy and the tolerability of many medications through complex pharmacokinetic and pharmacodinamic interactions. In fact, cigarette smoke, and in particular polycyclic aromatic hydrocarbons, nicotine, carbon monoxide and heavy metals, powerful enzymatic inducers, determines modifications of the sistemic and local bioavailability of several drugs. Therefore, in patients who are currently assuming any therapy, the clinicians should consider adjustments of dosages either when a smoker patient starts a new drug or when he quits smoking. The purpose of this review is to examine the main drug interactions with tobacco smoke clinically relevant that can be of particular importance especially in patients with multiple comorbidities, with a closer look on those who developed respiratory, cardiovascular, oncologic or psychiatric diseases. [less ▲]

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See detailInfluence of smoking on medication efficacy
Zagà, Vincenzo; Lygidakis, Charilaos UL

in Advances in Smoking Cessation (2013)

Detailed reference viewed: 80 (0 UL)
See detailPolonium and Cancer
Zagà, Vincenzo; Lygidakis, Charilaos UL

in Kretsinger, Robert H.; Uversky, Vladimir N.; Permyakov, Eugene A. (Eds.) Encyclopedia of Metalloproteins (2013)

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See detailPolonium and lung cancer.
Zaga, Vincenzo; Lygidakis, Charilaos UL; Chaouachi, Kamal et al

in Journal of oncology (2011), 2011

The alpha-radioactive polonium 210 (Po-210) is one of the most powerful carcinogenic agents of tobacco smoke and is responsible for the histotype shift of lung cancer from squamous cell type to ... [more ▼]

The alpha-radioactive polonium 210 (Po-210) is one of the most powerful carcinogenic agents of tobacco smoke and is responsible for the histotype shift of lung cancer from squamous cell type to adenocarcinoma. According to several studies, the principal source of Po-210 is the fertilizers used in tobacco plants, which are rich in polyphosphates containing radio (Ra-226) and its decay products, lead 210 (Pb-210) and Po-210. Tobacco leaves accumulate Pb-210 and Po-210 through their trichomes, and Pb-210 decays into Po-210 over time. With the combustion of the cigarette smoke becomes radioactive and Pb-210 and Po-210 reach the bronchopulmonary apparatus, especially in bifurcations of segmental bronchi. In this place, combined with other agents, it will manifest its carcinogenic activity, especially in patients with compromised mucous-ciliary clearance. Various studies have confirmed that the radiological risk from Po-210 in a smoker of 20 cigarettes per day for a year is equivalent to the one deriving from 300 chest X-rays, with an autonomous oncogenic capability of 4 lung cancers per 10000 smokers. Po-210 can also be found in passive smoke, since part of Po-210 spreads in the surrounding environment during tobacco combustion. Tobacco manufacturers have been aware of the alpha-radioactivity presence in tobacco smoke since the sixties. [less ▲]

Detailed reference viewed: 36 (1 UL)