References of "Neil, D"
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See detailReconstruction of biological networks through gene silencing and overexpression
Russell, H.; Goncalves, Jorge UL; Neil, D. et al

in Proceedings of the eighth International Conference on Systems Biology (2007)

Many methods that exist for reconstructing biological networks take into account assumptions of sparsity or already known relationships among states of the network. We show that we can completely ... [more ▼]

Many methods that exist for reconstructing biological networks take into account assumptions of sparsity or already known relationships among states of the network. We show that we can completely characterize the relationships among observed states and inputs in a linearized network through a series of easily performed biological experiments--inducible overexpression and gene silencing. We briefly review dynamical structure and give conditions for a set of experiments that will give all necessary information to obtain the structure. [less ▲]

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See detailMathematical models of circadian Ca2+ oscillations
Neil, D.; Goncalves, Jorge UL; Webb, A.R.

in Proceedings of the eighth International Conference on Systems Biology (2007)

In the model plant Arabidopsis thaliana, the concentration of cytosolic-free Ca2+ ([Ca2+]cyt) oscillates with a circadian rhythm. We are investigating the regulation and role of these oscillations both ... [more ▼]

In the model plant Arabidopsis thaliana, the concentration of cytosolic-free Ca2+ ([Ca2+]cyt) oscillates with a circadian rhythm. We are investigating the regulation and role of these oscillations both experimentally and mathematically. Through systems identification, we have developed simple mathematical models from a single experiment measuring [Ca2+]cyt and the promoter activity of CIRCADIAN CLOCK ASSOCIATED 1 (CCA1). Through validation with 4 contrasting datasets, including a clock-arrhythmic transgenic line (CCA1 overexpressor), we demonstrate the necessity for a light input pathway to regulate basal [Ca2+]cyt levels. [less ▲]

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