References of "Bullinger, E"
     in
Bookmark and Share    
Peer Reviewed
See detailReduction of mathematical models of signal transduction networks: simulation-based approach applied to EGF receptor signalling.
Conzelmann, H.; Saez-Rodriguez, J.; Sauter, Thomas UL et al

in Systems biology (2004), 1(1), 159-69

Biological systems and, in particular, cellular signal transduction pathways are characterised by their high complexity. Mathematical models describing these processes might be of great help to gain ... [more ▼]

Biological systems and, in particular, cellular signal transduction pathways are characterised by their high complexity. Mathematical models describing these processes might be of great help to gain qualitative and, most importantly, quantitative knowledge about such complex systems. However, a detailed mathematical description of these systems leads to nearly unmanageably large models, especially when combining models of different signalling pathways to study cross-talk phenomena. Therefore, simplification of models becomes very important. Different methods are available for model reduction of biological models. Importantly, most of the common model reduction methods cannot be applied to cellular signal transduction pathways. Using as an example the epidermal growth factor (EGF) signalling pathway, we discuss how quantitative methods like system analysis and simulation studies can help to suitably reduce models and additionally give new insights into the signal transmission and processing of the cell. [less ▲]

Detailed reference viewed: 225 (6 UL)
See detailDetailed Mathematical Modeling of Metabolic and Regulatory Networks
Sauter, Thomas UL; Bullinger, E.

in BIOforum Europe (2004), 02

Detailed reference viewed: 122 (3 UL)
Peer Reviewed
See detailAn approach for dividing models of biological reaction networks into functional units
Ederer, M.; Sauter, Thomas UL; Bullinger, E. et al

in Simulation (2003), 79

Detailed reference viewed: 74 (0 UL)
Peer Reviewed
See detailBiosystems Engineering: Applying methods from systems theory to biological systems
Kremling, A.; Sauter, Thomas UL; Bullinger, E. et al

in Proceedings of the 2nd International Conference on Systems Biology 4.-7.11.2001, Pasadena (2001)

Detailed reference viewed: 77 (0 UL)