References of "Beier, H. M."
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See detailDirect effects of nicotine on rabbit preimplantation embryos.
Balling, Rudi UL; Beier, H. M.

in Toxicology (1985), 34(4), 309-13

The effects of various concentrations of nicotine on the in vitro development of 1-cell rabbit preimplantation embryos and on the DNA-synthesis of 4-day-old rabbit blastocysts are investigated. Exposure ... [more ▼]

The effects of various concentrations of nicotine on the in vitro development of 1-cell rabbit preimplantation embryos and on the DNA-synthesis of 4-day-old rabbit blastocysts are investigated. Exposure of rabbit preimplantation embryos to concentrations of nicotine higher than 1 X 10(-3) M results in a marked decrease in the in vitro development and in DNA-synthesis. Concentrations of nicotine below 1 X 10(-3) M have no effect on these early embryos. It can be concluded that the concentrations of nicotine which exert a direct embryotoxic effect are higher than the concentrations that may be expected in the blood circulation of humans considered to be "normal smokers". [less ▲]

Detailed reference viewed: 142 (1 UL)
Peer Reviewed
See detailOxidative and conjugative metabolism of diethylstilbestrol by rabbit preimplantation embryos.
Balling, Rudi UL; Haaf, H.; Maydl, R. et al

in Developmental Biology (1985), 109(2), 370-4

Five- and six-day-old rabbit preimplantation embryos were found to be capable of metabolizing [3H]diethylstilbestrol (DES) in vitro. Based on the analysis of the metabolites formed during a 24-hr ... [more ▼]

Five- and six-day-old rabbit preimplantation embryos were found to be capable of metabolizing [3H]diethylstilbestrol (DES) in vitro. Based on the analysis of the metabolites formed during a 24-hr incubation period we conclude that these early stage embryos do have active monooxygenase and conjugative activity. The monooxygenase seems to be specific to this early stage of embryonic development. [less ▲]

Detailed reference viewed: 152 (0 UL)