![]() ; Aho, Velma ![]() in Annals of Neurology (2020) Objective: Alterations of the gut microbiome in Parkinson disease (PD) have been repeatedly demonstrated. However, little is known about whether such alterations precede disease onset and how they relate ... [more ▼] Objective: Alterations of the gut microbiome in Parkinson disease (PD) have been repeatedly demonstrated. However, little is known about whether such alterations precede disease onset and how they relate to risk and prodromal markers of PD. We investigated associations of these features with gut microbiome composition. Methods: Established risk and prodromal markers of PD as well as factors related to diet/lifestyle, bowel function, and medication were studied in relation to bacterial α-/β-diversity, enterotypes, and differential abundance in stool samples of 666 elderly TREND (Tübingen Evaluation of Risk Factors for Early Detection of Neurodegeneration) study participants. Results: Among risk and prodromal markers, physical activity, occupational solvent exposure, and constipation showed associations with α-diversity. Physical activity, sex, constipation, possible rapid eye movement sleep behavior disorder (RBD), and smoking were associated with β-diversity. Subthreshold parkinsonism and physical activity showed an interaction effect. Among other factors, age and urate-lowering medication were associated with α- and β-diversity. Physical inactivity and constipation were highest in individuals with the Firmicutes-enriched enterotype. Constipation was lowest and subthreshold parkinsonism least frequent in individuals with the Prevotella-enriched enterotype. Differentially abundant taxa were linked to constipation, physical activity, possible RBD, smoking, and subthreshold parkinsonism. Substantia nigra hyperechogenicity, olfactory loss, depression, orthostatic hypotension, urinary/erectile dysfunction, PD family history, and the prodromal PD probability showed no significant microbiome associations. Interpretation: Several risk and prodromal markers of PD are associated with gut microbiome composition. However, the impact of the gut microbiome on PD risk and potential microbiome-dependent subtypes in the prodrome of PD need further investigation based on prospective clinical and (multi)omics data in incident PD cases. [less ▲] Detailed reference viewed: 102 (3 UL)![]() ; ; Aho, Velma ![]() in Journal of Parkinson's Disease (2019), 9(s2), 297-312 Detailed reference viewed: 70 (1 UL)![]() Aho, Velma ![]() in EBioMedicine (2019), 44 Background: Several publications have described differences in cross-sectional comparisons of gut microbiota between patients with Parkinson's disease and control subjects, with considerable variability ... [more ▼] Background: Several publications have described differences in cross-sectional comparisons of gut microbiota between patients with Parkinson's disease and control subjects, with considerable variability of the reported dif- ferentially abundant taxa. The temporal stability of such microbiota alterations and their relationship to disease progression have not been previously studied with a high-throughput sequencing based approach. Methods: We collected clinical data and stool samples from 64 Parkinson's patients and 64 control subjects twice, on average 2·25 years apart. Disease progression was evaluated based on changes in Unified Parkinson's Disease Rating Scale and Levodopa Equivalent Dose, and microbiota were characterized with 16S rRNA gene amplicon sequencing. Findings: We compared patients to controls, and patients with stable disease to those with faster progression. There were significant differences between microbial communities of patients and controls when corrected for confounders, but not between timepoints. Specific bacterial taxa that differed between patients and controls at both timepoints included several previously reported ones, such as Roseburia, Prevotella and Bifidobacterium. In progression comparisons, differentially abundant taxa were inconsistent across methods and timepoints, but there was some support for a different distribution of enterotypes and a decreased abundance of Prevotella in faster-progressing patients. Interpretation: The previously detected gut microbiota differences between Parkinson's patients and controls persisted after 2 years. While we found some evidence for a connection between microbiota and disease progres- sion, a longer follow-up period is required to confirm these findings. [less ▲] Detailed reference viewed: 56 (1 UL)![]() ; Aho, Velma ![]() in Experimental Dermatology (2018), 27(1), 30-36 Detailed reference viewed: 68 (0 UL)![]() ; Aho, Velma ![]() in Acta Obstetricia et Gynecologica Scandinavica (2018), 97(1), 38-46 Detailed reference viewed: 56 (1 UL)![]() ; Aho, Velma ![]() in Parkinsonism and Related Disorders (2017), 38 Detailed reference viewed: 48 (0 UL)![]() ; ; Aho, Velma ![]() in Acta Dermato Venereologica (2017), 97(6), 685-691 Detailed reference viewed: 52 (0 UL)![]() ; Aho, Velma ![]() in Experimental Dermatology (2017), 26(10), 861-867 Detailed reference viewed: 45 (0 UL)![]() ; Aho, Velma ![]() in European Journal of Neurology (2017), 24(11), 1375-1383 Detailed reference viewed: 61 (0 UL)![]() ; Aho, Velma ![]() in PLoS ONE (2017), 12(8), 0182924 Detailed reference viewed: 103 (0 UL)![]() ; Aho, Velma ![]() in European Journal of Dermatology (2016), 26(1), 49-55 Detailed reference viewed: 60 (0 UL)![]() Aho, Velma ![]() in World Allergy Organization Journal (2015), 8(1), 23-015-0074- Detailed reference viewed: 53 (1 UL)![]() ; Aho, Velma ![]() in Movement Disorders (2015), 30(3), 350-358 Detailed reference viewed: 50 (0 UL) |
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