Application of statistical shape analysis to the differentiation of cancers appearing in childhood

Scientific Conference (2009, June 20)

Application of Statistical Shape Analysis to the Classification of Renal Tumours Appearing in Childhood

Scientific Conference (2009, April 23)

Applying Shape Analysis in Medecine and Engineering

in Bulletin of the Transilvania University of Brasov. Series III: Mathematics, Informtics, Physics (2009), 2(51), 59-74

We describe two applications of statistical shape analysis. For the differentiation of the different kidney tumours appearing in early childhood we use shape analysis of two-dimensionnal MRI images. For ... [more ▼]

We describe two applications of statistical shape analysis. For the differentiation of the different kidney tumours appearing in early childhood we use shape analysis of two-dimensionnal MRI images. For the analysis of odours in biogas plants, we use shape analysis to interpret the data provided by electronic noses. [less ▲]

Applications de l'Art Thérapie. Approche clinique et expérimentale intégrée Tome 1 : Domaine psychopédagogique et développemental

Book published by Saint-Paul (2009)

Analysing the relationship between Biographical Events and the Current Structural Functioning of Personality (en collaboration avec L. Schiltz (CRP-Santé).

in Bulletin de la Société des Sciences Médicales du Grand-Duché de Luxembourg (2008), 1

We present the general structure of a multi-annual research project. Our general expectancy concerns the possibilities of arts psychotherapy as a means of launching the blocked process of subjectivation ... [more ▼]

We present the general structure of a multi-annual research project. Our general expectancy concerns the possibilities of arts psychotherapy as a means of launching the blocked process of subjectivation with people suffering from exclusion, precarity and marginalization. The research project follows a complex research design with a sequential strategy, the first part consisting in an integrated psychosocial and clinical study using a mixed methodology. We constructed special rating scales for the analysis of the data of a semi-structured biographical interview and also for the holistic interpretation of the Rotter Blank Sentences Test, separating the associations to sentences beginning with the third and first person. The correlations between two sets of variables (biographical interview and Rotter test) were computed for the total experimental group (N=206), and for clinical subgroups. We shall analyse the matrices of correlations (Spearman's Rho) with the help of optimal scaling procedures (OVERALS). The links between traumatic biographical events and responses to the 3rd, respectively 1st person items of the Rotter test are interpreted in terms of unconscious versus conscious psychological processes and allow us analysing the expression of defence mechanisms and coping strategies. The results of the study are discussed in the light of the recent traumatogenic hypothesis of borderline functioning. [less ▲]

Developing and Evaluating a Computerized Adaptive Mathematical Test

in Stemmler, Mark; Lautsch, Erwin; Martinke, Dirk (Eds.) Configural Frequency Analysis (CFA) and other non-parametrical methods: Gustav A. Lienert Memorial Issue. (2008)

The theoretical basis underlying the construction of a CAT is summed up and the item response theory explained. In comparison with a classical paper-and-pencil test, the characteristics and the advantages ... [more ▼]

The theoretical basis underlying the construction of a CAT is summed up and the item response theory explained. In comparison with a classical paper-and-pencil test, the characteristics and the advantages of a CAT are exposed. After performing a thorough analysis of the data, we developed a CAT based on the responses of 3590 children to a standardized mathematical test. The software presents a great amount of flexibility and allows treating multiple-choice items, as well as items with free response options and graphical items. Some results of an empirical evaluating study are presented. We showed that qualities of power, flexibility and economy of time of the CAT do not imply the loss of the classical psychometric properties of a paper-and-pencil test; we analyze the carry-over effect between the computerized and the paper-and-pencil test situation and as well as the relations between mathematical skills and general cognitive abilities. [less ▲]

Partial Least Squares Regression for Qualitative Variables

Scientific Conference (2007, June 01)

Nuclear receptors in human immune cells: expressions and correlations

in Molecular Immunology (2007), 44

Nuclear receptors (NR) are key modulators of gene transcription. Their activity is ligand induced and modulates a large variety of tissue-specific cellular functions. However, for many NR little is known ... [more ▼]

Nuclear receptors (NR) are key modulators of gene transcription. Their activity is ligand induced and modulates a large variety of tissue-specific cellular functions. However, for many NR little is known about their role in cells of the immune system. In this study, expression patterns and distribution of 24 NR were investigated in human peripheral blood mononuclear cells.We provide the first evidence of the expression of the 12 receptors CAR, CoupTF , CoupTF , FXR, GCNF, HNF4 , PPAR / , PXR, RevErb , TR2, TR4 and TLX in highly purified CD4, CD8, CD19, CD14 cells. The expression profile of RevErb and LXR previously observed in B cell and macrophages, respectively, has been extended to CD4, CD8 and CD14 cells. Except for RAR , which was absence in any of the cells tested, our results suggest an almost ubiquitous expression of the NR in the different cell lineages of the immune system. The expression of CAR, CoupTF , FXR was also confirmed at a protein level and despite conspicuous mRNA levels of HNF4 , only low levels of this receptor were detectable in the nuclear fraction of PBMCs. Expression of the latter receptors was mostly only a fraction (4–20%) of their expression in the thyroid gland, the adrenal gland, the lung or subcutaneous adipose tissue. The Spearman rank order correlation test was performed to examine the correlation in expression between individual nuclear receptor pairs in the four cell types for several donors. Distinct correlation patterns were observed between receptor pairs in the individual cell types. In CD4 T cells four NR, GCNF, PPAR , PPAR 7 and RevErb are perfectly correlated with each other (P≥0.0167). In the other cell types correlations betweenNRpairs were more diverse, but also statistically highly significant. Interestingly, the relative expression level of a number of receptor pairs ranked identical or similar in at least three (CoupTF and PPAR / , CoupTF andHNF4 as well asROR and PXR) or four cell types (CoupTF and CoupTF , PPAR and RevErb ). Despite the variability of NR expression in immune cells, these results suggest that some of the NR may be co-regulated in human immune cells. [less ▲]

Application de l'art thérapie à quelques problèmes cruciaux de la société luxembourgeoise. Approche clinique et expérimentale. Recherche théorique et méthodologique. 3e partie

Report (2007)

Filtrage non linéairede diffusions faiblement bruitées dans le cas d'un système avec bruits corrélés

Scientific Conference (2006, August 31)