![]() Mizera, Andrzej ![]() ![]() in IEEE/ACM Transactions on Computational Biology and Bioinformatics (2018), 15(4), 1203-1216 Detailed reference viewed: 99 (4 UL)![]() Mizera, Andrzej ![]() ![]() in Proceedings of the 16th International Conference on Computational Methods in Systems Biology (2018) Detailed reference viewed: 133 (3 UL)![]() Paul, Soumya ![]() ![]() in Proceedings of the 2018 ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics (2018) Detailed reference viewed: 135 (4 UL)![]() ; ; Pang, Jun ![]() in Proceedings of the 33rd ACM/IEEE International Conference on Automated Software Engineering (2018) Detailed reference viewed: 111 (1 UL)![]() Paul, Soumya ![]() ![]() in Proceedings of the 16th International Conference on Computational Methods in Systems Biology (2018) Detailed reference viewed: 117 (4 UL)![]() ; ; et al in Proceedings of The Web Conference 2018 (WWW'18) (2018) Detailed reference viewed: 61 (2 UL)![]() ; ; et al in International Journal on Software Tools for Technology Transfer (2018), 20(6), 689-704 Detailed reference viewed: 119 (4 UL)![]() ; ; et al in ACM Transactions on Computational Logic (2018), 19(4), 1-27 Detailed reference viewed: 146 (1 UL)![]() Paul, Soumya ![]() ![]() in Proceedings of the 4th International Symposium on Dependable Software Engineering. Theories, Tools, and Applications (2018) Detailed reference viewed: 92 (1 UL)![]() Mizera, Andrzej ![]() ![]() ![]() in IEEE/ACM Transactions on Computational Biology and Bioinformatics (2018), 15(5), 1525-1537 Probabilistic Boolean networks (PBNs) is a well-established computational framework for modelling biological systems. The steady-state dynamics of PBNs is of crucial importance in the study of such ... [more ▼] Probabilistic Boolean networks (PBNs) is a well-established computational framework for modelling biological systems. The steady-state dynamics of PBNs is of crucial importance in the study of such systems. However, for large PBNs, which often arise in systems biology, obtaining the steady-state distribution poses a significant challenge. In this paper, we revive the two-state Markov chain approach to solve this problem. This paper contributes in three aspects. First, we identify a problem of generating biased results with the approach and we propose a few heuristics to avoid such a pitfall. Secondly, we conduct an extensive experimental comparison of the extended two-state Markov chain approach and another approach based on the Skart method. We analyse the results with machine learning techniques and we show that statistically the two-state Markov chain approach has a better performance. Finally, we demonstrate the potential of the extended two-state Markov chain approach on a case study of a large PBN model of apoptosis in hepatocytes. [less ▲] Detailed reference viewed: 163 (7 UL)![]() Pang, Jun ![]() Book published by IEEE Computer Society (2018) Detailed reference viewed: 55 (2 UL)![]() Mizera, Andrzej ![]() ![]() in Proceedings of the 3rd International Symposium on Dependable Software Engineering: Theories, Tools, and Applications (2017) Detailed reference viewed: 164 (5 UL)![]() Pang, Jun ![]() in Proceedings of the 11th International Conference on Web and Social Media (ICWSM'17) (2017) Detailed reference viewed: 123 (6 UL)![]() Pang, Jun ![]() in Proc. 28th ACM Conference on Hypertext and Social Media - HT'17 (2017) Detailed reference viewed: 129 (1 UL)![]() ; ; Yuan, Qixia ![]() in Proceedings of 20th International Conference on Fundamental Approaches to Software Engineering (2017) Detailed reference viewed: 146 (11 UL)![]() ; ; et al in Proceedings of the 16th IEEE/WIC/ACM International Conference on Web Intelligence (WI'17) (2017) Detailed reference viewed: 129 (1 UL)![]() ; ; Pang, Jun ![]() in Computers and Security (2017), 65 Detailed reference viewed: 181 (2 UL)![]() ; ; Pang, Jun ![]() in Proceedings of the 24th ACM International Conference on Computer and Communications Security (2017) Detailed reference viewed: 111 (5 UL)![]() ; ; Pang, Jun ![]() in Proceedings of the 19th International Conference on Formal Engineering Methods (2017) Detailed reference viewed: 147 (1 UL)![]() ; ; Pang, Jun ![]() in Proceedings of the 26th ACM International Conference on Information and Knowledge Management - CIKM'17 (2017) Detailed reference viewed: 130 (1 UL) |
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