![]() Trairatphisan, Panuwat ![]() ![]() ![]() in Cell Communication and Signaling (2013), 11(46), Probabilistic Boolean network (PBN) modelling is a semi-quantitative approach widely used for the study of the topology and dynamic aspects of biological systems. The combined use of rule-based ... [more ▼] Probabilistic Boolean network (PBN) modelling is a semi-quantitative approach widely used for the study of the topology and dynamic aspects of biological systems. The combined use of rule-based representation and probability makes PBN appealing for large-scale modelling of biological networks where degrees of uncertainty need to be considered. A considerable expansion of our knowledge in the field of theoretical research on PBN can be observed over the past few years, with a focus on network inference, network intervention and control. With respect to areas of applications, PBN is mainly used for the study of gene regulatory networks though with an increasing emergence in signal transduction, metabolic, and also physiological networks. At the same time, a number of computational tools, facilitating the modelling and analysis of PBNs, are continuously developed. A concise yet comprehensive review of the state-of-the-art on PBN modelling is offered in this article, including a comparative discussion on PBN versus similar models with respect to concepts and biomedical applications. Due to their many advantages, we consider PBN to stand as a suitable modelling framework for the description and analysis of complex biological systems, ranging from molecular to physiological levels. [less ▲] Detailed reference viewed: 274 (32 UL)![]() Mizera, Andrzej ![]() ![]() ![]() in Proceedings of 4th Workshop on Computational Models for Cell Processes (CompMod'13) (2013) Detailed reference viewed: 95 (10 UL)![]() Mizera, Andrzej ![]() ![]() ![]() in Proceedings of 11th Conference on Computational Methods in Systems Biology (CMSB'13) (2013) Detailed reference viewed: 84 (8 UL)![]() Mizera, Andrzej ![]() in Lecture Notes in Computer Science (2012), 7625 Detailed reference viewed: 61 (0 UL)![]() Mizera, Andrzej ![]() in Katz, Evgeny (Ed.) Biomolecular Information Processing. From Logic Systems to Smart Sensors and Actuators (2012) Detailed reference viewed: 77 (1 UL)![]() ; Mizera, Andrzej ![]() in IEEE/ACM Transactions on Computational Biology and Bioinformatics (2012), 9(3), 885-898 Detailed reference viewed: 77 (2 UL)![]() ; Mizera, Andrzej ![]() in Fundamenta Informaticae (2012), 116(1-4), 51-63 Detailed reference viewed: 49 (1 UL)![]() Mizera, Andrzej ![]() Doctoral thesis (2011) Detailed reference viewed: 25 (4 UL)![]() ; Mizera, Andrzej ![]() in Natural Computing (2011), 10(1), 595-612 Detailed reference viewed: 93 (0 UL)![]() Mizera, Andrzej ![]() in Israel Journal of Chemistry (2011), 51(1), 151164 Detailed reference viewed: 78 (0 UL)![]() Mizera, Andrzej ![]() in Communications in Nonlinear Science & Numerical Simulation (2011), 16(5), 23422349 Detailed reference viewed: 86 (2 UL)![]() Mizera, Andrzej ![]() in Journal of Theoretical Biology (2010), 265(3), 455466 Detailed reference viewed: 80 (2 UL)![]() ; ; et al in Archives of Acoustics (2009), 34(4), 445459 Detailed reference viewed: 32 (2 UL)![]() Mizera, Andrzej ![]() in Awrejcewicz, J.; Kaźmierczak, M.; Mrozowski, J. (Eds.) et al 10th Conference on Dynamical Systems – Theory and Applications, DSTA-2009 (2009) Detailed reference viewed: 28 (1 UL)![]() ; Mizera, Andrzej ![]() in Condon, Anne; Harel, David; Kok, Joost N. (Eds.) et al Algorithmic Bioprocesses (2009) Detailed reference viewed: 91 (0 UL)![]() ; Mizera, Andrzej ![]() in Lecture Notes in Computer Science (2009), 5635 Detailed reference viewed: 136 (0 UL)![]() ; ; Mizera, Andrzej ![]() in BMC Bioinformatics (2006), 7 Detailed reference viewed: 61 (6 UL) |
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