References of "De Beaufort, Carine 50001475"
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See detailHLA Dr3 is associated with a more slowly progressive form of IDDM
Ludvigsson, J.; Samuelson, U.; De Beaufort, Carine UL et al

in Diabetologia (1986), 29

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See detailSchedule on self blood glucose monitoring in children under 6 years of age
Bruining, C.J.; De Beaufort, Carine UL; Houtzagers, C.M.G.J.

in Pediatric and Adolescent Endocrinology (1986), (15),

Detailed reference viewed: 33 (2 UL)
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See detailThe influence of continuous subcutaneous insulin infusion on the remission period in IDDM
De Beaufort, Carine UL; Bruining, G.J.; Aarsen, R.S.R et al

in Pediatric and Adolescent Endocrinology (1986), 15

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See detailOvernight metabolic profiles in very young insulin-dependent diabetic children
De Beaufort, Carine UL; Bruining, G. J.; Home, P. D. et al

in European Journal of Pediatrics (1986), 145(1-2), 73-76

The magnitude of the disturbance of metabolic control in diabetes mellitus in very young children has been recognised, but seldom studied. Limitations to studies are set by the difficulty of obtaining ... [more ▼]

The magnitude of the disturbance of metabolic control in diabetes mellitus in very young children has been recognised, but seldom studied. Limitations to studies are set by the difficulty of obtaining control data and until recently the lack of alternative therapies. Recently "mini" pumps for continuous subcutaneous insulin delivery have become available and may offer an alternative therapeutic possibility. The present investigation has been undertaken to collect overnight metabolic data of very young diabetic children (<6 years) controlled by standard injection therapy. During one admission to hospital frequent blood samples were collected for free insulin, glucose, alanine, lactate, glycerol and 3-hydroxybutyrate determinations. In all children (n=9) the profiles showed a steep rise in glucose from 04.30h (6.2±1.3 mmol/l) to 09.30h (17.8±2.4 mmol/l) (the so-called "dawn-phenomenon"). The nature of the changes in the intermediary metabolites suggested that rise in blood glucose was caused by insufficient insulin. We have attempted to explore the time relationship between the overnight drop in free insulin levels and the rises in blood glucose by a distribution-free statistical analysis, correlating successive changes in time between the two profiles. The analysis suggested a delay of 2-6 h between free insulin levels and their effects. In conclusion: a clear "dawn phenomenon" is seen in very young diabetic children, and contributes to their poor glycaemic control. More stable and higher insulin concentrations in the early morning, obtained perhaps by continuous subcutaneous insulin infusion, might ameliorate the overall glycaemic control in the very young diabetic child. © 1986 Springer-Verlag. [less ▲]

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See detailDoes continuous subcutaneous insulin infusion (CSII) prolong the remission phase of insulin-dependent diabetic children? Preliminary findings of a randomized prospective study
De Beaufort, Carine UL; Bruining, G. J.; Aarsen, R. S. R. et al

in Netherlands Journal of Medicine (1985), 28(SUPPL. 1), 53-54

[No abstract available]

Detailed reference viewed: 35 (0 UL)