![]() ; ; Schommer, Christoph ![]() Poster (2016, November) Detailed reference viewed: 117 (3 UL)![]() ; ; et al in Neurology, Psychiatry and Brain Research (2016) Detailed reference viewed: 158 (0 UL)![]() ; ; et al Scientific Conference (2016, July 14) Detailed reference viewed: 89 (5 UL)![]() ; ; et al in European Journal of Neuroscience (2016) Detailed reference viewed: 107 (3 UL)![]() Genty, Julien ![]() ![]() ![]() Scientific Conference (2016) Detailed reference viewed: 106 (13 UL)![]() Scheuren, Raymonde ![]() ![]() in Psychophysiology (2016), 53(8), 1282-1291 Numerous studies have documented an inverse relationship between blood pressure and sensitivity to experimental nociceptive stimulation. The present study aimed to investigate possible associations ... [more ▼] Numerous studies have documented an inverse relationship between blood pressure and sensitivity to experimental nociceptive stimulation. The present study aimed to investigate possible associations between blood pressure and the occurrence and intensity of paradoxical pain induced by the thermal grill paradigm. Thirty-one healthy subjects were stimulated three times for 1 minute with the non-noxious temperatures of 15°C and 41°C set at the interlaced cold and warm bars of a water bath-driven thermal grill. Blood pressure and heart rate were recorded concomitantly. On account of previous observations of an association between the sensitivity of the cardiac baroreflex and pain perception, this parameter was additionally obtained. Numerical rating scales were used to quantify subjective pain intensity and pain unpleasantness; subjects were classified as responders and non-responders to thermal grill stimulation based on pain intensity ratings. Responders exhibited lower systolic and diastolic blood pressure than non-responders, and inverse linear associations arose between blood pressure and pain intensity and unpleasantness. Baroreflex sensitivity was unrelated to pain ratings. The findings confirmed the hypothesis of a blood pressure dependence of paradoxical pain and support the notion that the cardiovascular and pain regulatory systems interact not only in the processing of pain elicited by noxious input, but also in non-noxiously generated illusive pain. While this finding is not consistent with the assumption of an involvement of the baroreflex system in mediating the observed interaction, psychological traits and neurochemical factors are alternatively considered. [less ▲] Detailed reference viewed: 210 (14 UL)![]() Scheuren, Raymonde ![]() ![]() in Journal of Psychophysiology (2016) Self-regulation mechanisms are governed by prefrontal inhibitory processes and play a crucial role in the modulation of pain. In the present study the thermal grill paradigm was used to investigate the ... [more ▼] Self-regulation mechanisms are governed by prefrontal inhibitory processes and play a crucial role in the modulation of pain. In the present study the thermal grill paradigm was used to investigate the association of vagally mediated resting heart rate variability, a psychophysiological marker of trait self-regulatory capacity, with paradoxical pain sensations induced by non-noxious stimulation. This thermal grill illusion is only perceived by part of the tested individuals. The mechanisms underlying the observed inter-individual differences in paradoxical pain sensitivity are largely unknown. During the experimental task, a temperature combination of 15° C and 41° C was set at the glass tubes of the thermal grill. The fifty-two healthy participants placed their dominant hand on the grill for a duration of one minute. The magnitude of sensory and affective pain sensations perceived during stimulation was assessed with numerical rating scales. Before stimulation, a short-term electrocardiogram was recorded to compute vagally mediated heart rate variability at rest. Logistic regression analyses revealed that participants with higher vagal tone were significantly more likely to perceive the thermal grill illusion than subjects displaying lower resting heart rate variability. Paradoxical pain sensations were primarily predicted by normalized respiratory sinus arrhythmia. Our results confirm that the magnitude of vagally mediated resting heart rate variability is associated with the individual disposition to illusive pain perceptions. Since the latter is considered to be a marker of trait self-regulation ability, the present findings may corroborate and complement previous evidence for an impact of psychological characteristics on paradoxical pain sensitivity. [less ▲] Detailed reference viewed: 206 (15 UL)![]() ; ; Zell, Vivien ![]() in European Journal of Neuroscience (2016) Detailed reference viewed: 145 (3 UL)![]() Scheuren, Raymonde ![]() ![]() Speeches/Talks (2015) Background: Evidence has been given that there exists a functional relationship between the cardiovascular and the pain regulatory system. Alterations in blood pressure and concomitant changes in ... [more ▼] Background: Evidence has been given that there exists a functional relationship between the cardiovascular and the pain regulatory system. Alterations in blood pressure and concomitant changes in baroreceptor activation contribute to the modulation of pain sensitivity It could be shown that blood pressure, baroreflex sensitivity, and cardiac vagal tone (indexed by heart rate variability, HRV) are inversely associated to pain sensitivity. We aimed assessing the same cardiovascular parameters in a thermal grill paradigm to test the assumption of a relationship between inter-individual differences in autonomic cardiac control and the perception of the thermal grill illusion of pain (TGI). Methods: All participants (N = 52) were stimulated three times during one minute with the temperatures of 15°C and 41°C set at the interlaced cold and warm bars of the water-bath driven thermal grill. Blood pressure and heart rate were recorded concomitantly. Numerical rating scales (NRS; 0–100) were used to quantify subjective paradoxical pain intensity and pain unpleasantness perceptions. Results: A positive association between cardiac vagal tone and paradoxical pain sensitivity could be revealed. Higher resting HRV, as expressed by higher respiratory sinus arrhythmia (RSA), made it overall more likely to perceive the TGI. In contrast, blood pressure and the susceptibility to the TGI were inversely related. Volunteers displaying higher spontaneous blood pressure values in the first thermal grill stimulation phase did not feel the illusive pain as compared to those who presented significantly lower sympathetic arousal and perceived the TGI. Conclusion: The present physiological findings complement previous evidence of an impact of psychological characteristics on the individual disposition to paradoxical pain perceptions. [less ▲] Detailed reference viewed: 189 (3 UL)![]() Scheuren, Raymonde ![]() ![]() Poster (2015, September 03) Alterations in blood pressure (BP) and concomitant changes in baroreceptor activation contribute to the modulation of pain sensitivity to warrant homeostatic regulation processes [1][2]. Numerous pain ... [more ▼] Alterations in blood pressure (BP) and concomitant changes in baroreceptor activation contribute to the modulation of pain sensitivity to warrant homeostatic regulation processes [1][2]. Numerous pain studies have described an inverse relationship between BP and nociceptive sensitivity [3][4][5]. It is not known whether a similar relationship plays a role in the framework of the induction of pain in the absence of noxious stimulation. The thermal grill (TG) paradigm is commonly used to trigger this type of paradoxical pain also termed thermal grill illusion of pain (TGI). The goal of the present study was to explore the relationship between cardiovascular activity/reactivity and paradoxical pain sensitivity to get additional insight in the variability of responsiveness (responders and non-responders) to TG stimulation described in the literature [6][7]. We hypothesized that higher BP would be associated with stronger pain inhibitory effects in participants not perceiving the thermal grill illusion of pain (TGI). We moreover expected that the perception of paradoxical pain in the responder group would be paired with lower BP. We tested this hypothesis by comparing both groups with respect to their spontaneous cardiovascular activity (recorded in resting conditions) and their cardiovascular responses to TG stimulation. [less ▲] Detailed reference viewed: 146 (4 UL)![]() ![]() Van Der Meulen, Marian ![]() ![]() Poster (2015, September) Detailed reference viewed: 118 (8 UL)![]() Bustan, Smadar ![]() in European Journal of Pain (2015) Detailed reference viewed: 173 (8 UL)![]() ![]() Genty, Julien ![]() ![]() ![]() Scientific Conference (2015) Detailed reference viewed: 112 (9 UL)![]() ; ; Hanesch, Ulrike ![]() in The European journal of neuroscience (2015) Corticosterone (CORT) is a glucocorticoid produced by adrenal glands under the control of the hypothalamic-pituitary-adrenal axis. Circulating CORT can enter the central nervous system and be reduced to ... [more ▼] Corticosterone (CORT) is a glucocorticoid produced by adrenal glands under the control of the hypothalamic-pituitary-adrenal axis. Circulating CORT can enter the central nervous system and be reduced to neuroactive 3alpha5alpha-reduced steroids, which modulate GABAA receptors. In the dorsal spinal cord, GABAergic transmission modulates integration of nociceptive information. It has been shown that enhancing spinal inhibitory transmission alleviates hyperalgesia and allodynia. Therefore, the spinal neuronal network is a pivotal target to counteract pain symptoms. Thus, any increase in spinal 3alpha5alpha-reduced steroid production enhancing GABAergic inhibition should reduce nociceptive message integration and the pain response. Previously, it has been shown that high levels of plasma glucocorticoids give rise to analgesia. However, to our knowledge, nothing has been reported regarding direct non-genomic modulation of neuronal spinal activity by peripheral CORT. In the present study, we used combined in vivo and in vitro electrophysiology approaches, associated with measurement of nociceptive mechanical sensitivity and plasma CORT level measurement, to assess the impact of circulating CORT on rat nociception. We showed that CORT plasma level elevation produced analgesia via a reduction in C-fiber-mediated spinal responses. In the spine, CORT is reduced to the neuroactive metabolite allotetrahydrodeoxycorticosterone, which specifically enhances lamina II GABAergic synaptic transmission. The main consequence is a reduction in lamina II network excitability, reflecting a selective decrease in the processing of nociceptive inputs. The depressed neuronal activity at the spinal level then, in turn, leads to weaker nociceptive message transmission to supraspinal structures and hence to alleviation of pain. [less ▲] Detailed reference viewed: 126 (6 UL)![]() Anton, Fernand ![]() ![]() in Schmithüsen, Franziska (Ed.) Lernskript Psychologie - Die Grundlagenfächer kompakt (2015) Detailed reference viewed: 24 (0 UL)![]() ; Anton, Fernand ![]() in Schmithüsen, Franziska (Ed.) Lernskript Psychologie (2014) Detailed reference viewed: 265 (4 UL)![]() ; ; et al Scientific Conference (2014, October 10) Detailed reference viewed: 210 (1 UL)![]() ; ; et al Scientific Conference (2014, October 10) Detailed reference viewed: 87 (1 UL)![]() González Roldán, Ana Maria ![]() ![]() Scientific Conference (2014, October 10) Detailed reference viewed: 85 (1 UL)![]() Bustan, Smadar ![]() ![]() ![]() Poster (2014, October 07) Detailed reference viewed: 68 (6 UL) |
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